Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Phlebovirus"”.
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HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS
… Syndrome (SFTS) virus is an emerging tick-borne Phlebovirus isolated from patients presenting with hemorrhagic manifestations. Case fatality rates of 12-50% have been reported. Limited information regarding SFTS virus pathogenesis is known. Inhibition of interferon (IFN) responses by SFTS virus …
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Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
Rift Valley fever phlebovirus (RVFV) is a trisegmented, single-stranded, negative-sense RNA genome, consisting of L, M and S segments. The virion carries two envelope glycoproteins, Gn and Gc, along with ribonucleoprotein complexes (RNPs), composed of encapsidated genomes carrying the nucleocapsid …
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Reverse genetics system and fucntion of NSM protein of Rift Valley fever virus (family Bunyaviridae, genus phlebovirus)
Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease that is endemic in sub-Saharan African countries and results in large epidemics among humans and livestock. Furthermore, it has potential as a …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… affect on virulence in the hamster model of Phlebovirus pathogenesis. This study reports that PTV strains isolated west of the Panama Canal are not lethal in hamsters and phylogenetic analysis of the coding sequences reveals the presence of genetic clades, indicating that PTV strains occupy …
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Investigation of mosquito (diptera: culicidae)-borne viruses circulating in some selected areas of Lusaka district, Zambia.
… using a pan-flavivirus, pan-alphavirus, and pan-phlebovirus RT-PCR assay to detect the respective virus genera genome in total RNA extracted from the mosquito lysates. Phylogenetic analysis based on RNA-dependent RNA polymerase (RdRp) amino acid sequences was used to characterize the detected …
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Investigation of mosquito (diptera: culicidae)-borne viruses circulating in some selected areas of Lusaka district, Zambia.
… using a pan-flavivirus, pan-alphavirus, and pan-phlebovirus RT-PCR assay to detect the respective virus genera genome in total RNA extracted from the mosquito lysates. Phylogenetic analysis based on RNA-dependent RNA polymerase (RdRp) amino acid sequences was used to characterize the detected …
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Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana
… fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing high numbers of neonatal fatalities in animals and occasional fatalities in humans. It is endemic to parts of Africa and the …
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Papel de las aves en la dispersión de garrapatas y microorganismos que vehiculan
… hemorrhagic fever virus, Flavivirus, Phlebovirus, Coltivirus and Orbivirus) using molecular biology techniques. In these studies, ticks belonging to five species (Haemaphysalis punctata, Hyalomma marginatum, Ixodes arboricola, Ixodes frontalis and Ixodes ricinus) and captured over …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
… RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and general transcription shutoff including IFN-β mRNA synthesis. Currently, no effective measures have been …
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The study of ancient viral class II envelope fusion proteins within the viral retroelements of Nematoda and the nuclear plasmids of Dictyostelium
… within the phylum Nematoda have acquired a phlebovirus-like env and utilized the encoded fusion machinery to escape the genome as intact and novel exogenous retrovirus. This includes C. elegans retroelement 13 virus which was recently reclassified as a member of the genus Semotivirus. A 3.76 …
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NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
… as Dabie Bandavirus) is an emergent tick-borne Phlebovirus isolated from patients presenting with hemorrhagic manifestations. Case fatality rates range from 12-50%, and over 1 billion people live in regions where the virus is endemic. SFTS virus pathogenesis remains understudied despite it being …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
Rift Valley fever virus (RVFV) is a phlebovirus of the virus family, Bunyaviridae. Since the early 1900s, RVFV has continually caused economically devastating outbreaks in livestock and severe disease in humans. In pregnant ewes, RVFV infection can cause abortions in up to 100% of animals and high …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
Rift Valley fever Phlebovirus (RVFV) ist ein Mitglied der Familie Bunyaviridae. Es wird durch Stechmücken übertragen und ist in der Lage zahlreiche Wirtspezies zu infizieren. Beim Menschen kann die Infektion zu Hepatitis, hämorrhagischem Fieber und Enzephalitis mit tödlichem Ausgang führen. Bei …