Global ETD Search
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Showing 1 to 3 of 3 for “"Phi-Value"”.
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Probing Order within Intrinsically Disordered Proteins
… the disordered protein sequence? Utilising phi-value analysis on the BCL-2 family of proteins, residues in the disordered sequence were probed to ascertain which form contacts at the transition state of the reaction. Comparison with phi-value analyses of alternative pairs – sharing either …
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Functional Relevance of Protein Disorder: Why is Disorder Favourable?
… be important in signalling processes. Further, phi-value analysis applied to investigate the mechanism of interaction reveals that non-native interactions play a key role in this reaction, before the IDP consolidates its final structure in the bound complex. Promiscuous interaction of IDPs with …
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From disorder to order: the importance of context in protein folding and binding mechanisms
… reaction: the IDP or the partner protein? Using phi-value analysis we studied four IDP-partner protein complexes, composed of alternative pairs of BCL-2 family members. In the bimolecular context, the disordered protein dictates the transition state interactions. Therefore, analogous to …