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Showing 1 to 20 of 20 for “"Phenytoin"”.
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Solubility Improvement by Solid Dispersion and Their Characterization: Indomethacin and Phenytoin
… water soluble drugs, namely indomethacin and phenytoin by formulating ternary solid dispersions with a carrier and an adsorbent. Urea was used as the dispersing agent for indomethacin, while Kollidon<sup>®</sup>VA64 was used for both indomethacin and phenytoin. Solid dispersions with urea and …
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
Eleven percent of children exposed in utero to phenytoin show a pattern of fetal hydantoin syndrome (FHS) which may include cleft lip/palate. Also, in utero exposure to the products of cigarette smoke leads to reduced birth weight, prematurity, and small but significant risk of oral clefts. Cleft …
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An electrophoretic study of fetal mouse brain proteins after in vivo exposure to phenytoin and disulfiram
Although there have been two-dimensional electrophoretic studies on fetal brain tissue (for instance, Yoshida and Takahashi, 1980), the emphasis in most of this work has been on developmental changes in protein expression, and not on the effects that drugs have on fetal brain protein complement. …
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Χορήγηση φαινυτοΐνης για την προφύλαξη του εγκεφάλου από υποξία
… with the light and electron microscope, whether phenytoin provides protection in cerebral hypoxia. Hypoxia (O₂ 5%, N₂O 95%) was applied in all groups of mice and rats. The rats were divided into four groups. Ar group: Hypoxia until death. Br group: Normal saline administration 20 min before …
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The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling
The pharmacokinetics of phenytoin is complicated by the nonlinearity of the dose-concentration relationship which is a consequence of capacity-limited metabolism. Individualized therapy with phenytoin is therefore optimally required. As no data are available on the population pharmacokinetics of …
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ΙΣΤΟΠΑΘΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΑΛΛΟΙΩΣΕΩΝ ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΤΟΥ ΗΠΑΤΟΣ ΚΑΙ ΤΩΝ ΝΕΦΡΩΝ ΑΠΟ ΤΟΞΙΚΕΣ ΔΟΣΕΙΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΑ ΚΟΥΝΕΛΙΑ
… RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN …
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Simultaneous quantitation of phenytoin, its major metabolites, and their stable isotope labelled analogs in biological fuids by gas chromatographic mass spectrometry
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1981.
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Zytochrom P450 in Gehirn und Leber der Maus (Mus Musculus) Über die Funktion von P450 im Testosteronmetabolismus und die Beeinflussung durch das Antiepileptikum Phenytoin
… exogene Substanzen, wie das Antiepileptikum Phenytoin, induzierbar. Einige dieser Enzyme sind am Metabolismus gonadaler Hormone beteiligt, welche eine wichtige Rolle bei Hirnentwicklung, -funktion und neuronaler Plastizität spielen. Allerdings ist nur wenig über die Expression und mögliche …
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Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
… the market, carbamazepine, phenobarbital and phenytoin are still the major agents in the pharmacotherapy of epilepsy. Therefore, phenytoin was chosen as a model AED and the effect of CYP2C9/2C19 genetic polymorphism on phenytoin metabolism was further examined.An estimation of the allele …
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Prediction of the Degradation of Emerging Contaminants During Oxidative Treatment via Analysis of Reaction Rate Constants
… emerging contaminants: caffeine, atrazine, and phenytoin, which were selected based on their persistence and ubiquity in the environment and their potential to serve as AOP efficacy indicator compounds. Reaction rate constants were determined from batch reactor data and compared to the …
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The development of functional in vitro toxicity tests
… incorporation, after eo-incubation with either phenytoin or cyclophosphamide (50µM) and the rat microsomal metabolite generating system. In the one compartment erythrocyte studies, there were significant decreases in glutathione with cyclophosphamide (50µM) (0.44 ± 0.04 mM), sulphamethoxazole …
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The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons
… (n = 31), carbamazepine (n = 15), phenytoin (n = 12), paracetamol (n = 29) and opioid-paracetamol mixtures (n = 17). They received standard hospital management of which sorbitol was not a part. Part 2 consisted of sixty-one patients who had sorbitol added to their treatment. These …
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Health technology assessment for levetiracetam in the treatment of newly diagnosed epilepsy in the South African Public Health Sector
… are levetiracetam, lamotrigine, carbamazepine, phenytoin and valproate. The current first-line epilepsy treatment in South Africa is lamotrigine, phenytoin or carbamazepine. Levetiracetam is under consideration for use as a first-line treatment due to the reported minimal serious side effects, …
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Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos
… in bioavailability of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. …
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A Clinical Characteristics of Adverse Drug Reaction in Pediatrics
… patients, 13%), Acetaminophen (8 patients, 8%), Phenytoin (12 patients, 12%), Anti-cancer medicine (4 patients, 4%), Sedative (1 patient, 1%) and Antiflammatory (1 patient, 1%). For 16 patients among them, drug challenge test was performed. As a result, the drugs that have shown positive reaction …
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Die Wirkung von Antikonvulsiva auf ATP-sensitive Kalium-Kanäle
… wurden nun zum Vergleich die Antikonvul-siva Phenytoin, Carbamazepin, Valproat und Lamotrigin untersucht. Mit der Ausnahme Valproats, zeigten alle der genannten Substanzen eine deutliche Hemmung der [3H]-Noradrenalin Freisetzung. Diese Wirkung ließ sich bei keiner der Substanzen durch den …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΧΡΟΝΙΑΣ ΧΟΡΗΓΗΣΗΣ ΔΙΦΑΙΝΥΛΟΔΑΝΤΟΙΝΗΣ ΣΤΗΝ ΠΩΡΩΣΗ ΠΡΟΚΛΗΤΩΝ ΚΑΤΑΓΜΑΤΩΝ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ ΕΠΙΜΥΩΝ
… THE CHRONIC ADMINISTRATIONOF DIPHENYLHYDANTOIN (PHENYTOIN-NATRIUM) HAS ANY INFLUENCE ON THE PROCESS OF HEALING OF MANDIBULAR FRACTURES IN YOUNG RATS. FOR THIS PURPOSE 45 FEMALE WISTARRATS WERE USED SEPARATED IN THREE GROUPS OF 15 RATS EACH. TWO OF THESE GROUPS CONSISTED FROM THE EXPERIMENTAL …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… of action of six prorotype antiepileptics (Phenytoin, Carbamazepine, Phénobarbital, Ethosuximide, Valproate and Midazolam). The possibility of their exerting their antiepileptic action through NMDA receptor antagonism was examined. The results suggest that this is unlikely, the exception …
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Investigations of Pharmacokinetic Challenges in Premature Infants
… in pediatric patients. Acetaminophen, caffeine, phenytoin, ranitidine, and theophylline are widely used in the pharmacotherapy of premature and term neonates, but only limited information is currently available on the PK of these medications in premature neonates. An accurate, sensitive and …
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Potential of Ozone and Hydroxyl Radicals to Degrade Emerging Organic Contaminants
… on the treatment of carbamazepine (CMZ) and phenytoin (PHT) in controlled water systems, ozonated phosphate buffer was mixed with CMZ stock solution to make a 0.25 uM CMZ solution or PHT stock solution to form a 0.25 PHT solution.</p> <p>The dissolved organic carbon was measured through a …