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Showing 1 to 4 of 4 for “"Phenylacetamide"”.
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
… C6-O linked benzimidazoles and C-4 benzamide and phenylacetamide benzimidazoles based on (R)-Roscovitine, a non-selective inhibitor of CDK-5 were designed and synthesized. </p><p>MEK-5, a member of the MAPK family, phosphorylates ERK-5 permitting cells to survive oxidative stress. MEK-5 is …
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Application of continuous flow technology to the expedient synthesis of isotopically substituted compounds
… substituted phenyl acetate, methoxybenzene, N-phenylacetamide and biphenyl derivatives in a timely manner using continuous flow systems. As proof of concept, small libraries comprising of compounds containing deuterium isotope labels were successfully prepared, generally in yields greater than …
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A study of various nucleophiles in aromatic SRN1 reactions
… Preliminary results showed that the reaction of phenylacetamide dianion with iodobenzene also gave rise to the para substituted product. The dianion of 1,3-phenylacetone was found to react with iodobenzene to give 1,1,3-triphenylacetone via a mechanism other than an S<sub>R</sub><sub>N</sub>1 …
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X-ray crystal structures of: [Rh2(N-{2,4,6-CH3}C6H2)COCH3)4]•2NCC6H4 AND Ba1.5[Fe(C10H13N2O7)][Co(CN)6]•9H2O; two crystallographic challenges
<p>The novel compound, [Rh<sub>2</sub>(N-{2,4,6-CH<sub>3</sub>}C<sub>6</sub>H<sub>2</sub>)COCH<sub>3</sub>)<sub>4</sub>] was synthesized. Crystal structures of [Rh<sub>2</sub>(N-{2,4,6-CH<sub>3</sub>}C<sub>6</sub>H<sub>2</sub>)COCH<sub>3</sub>)<sub>4</sub>]·2NCC<sub>6</sub>H<sub>5</sub> and …