Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Phenotypic switching"”.
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Phenotypic Switching of Bacterial Cells in Extreme Environments
<p>A large number of terrestrial microbial lives thrive in extremes of environmental conditions, including extremes of pressure, temperature, salinity, pH, and a combination of them. For example, all the marine biomass thrive at high hydrostatic pressure depending on depth. The temperature in the …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
… cytokines. This process is termed phenotypic switching and can lead to VSMC accumulation within atherosclerotic plaques. Previous observations of clonal expansion of a small number of VSMCs in atherosclerosis suggested that VSMCs were functionally heterogeneous. I hypothesised that …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… accompany vascular smooth muscle cell (VSMC) phenotypic switching, a hallmark of vascular disease. Upon insult, VSMCs downregulate contractile proteins and upregulate genes linked to vascular remodelling, such as matrix metalloproteinases (MMPs) and pro-inflammatory cytokines. However, the …
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… VSMCs showed hallmarks of abnormal synthetic phenotypic switching, driven by increased matrix stiffness, confirming the importance of VSMC state in aortic wall homeostasis. Increased mitochondrial basal respiration revealed metabolic defects in MYLK and SMAD4 mutants. Distinct phenotypes were …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
… cell genomic method is crucial for deciphering phenotypic heterogeneity. Here, we profiled single cell transcriptomes from genetically engineered mouse lung tumors at seven stages spanning tumor progression from atypical adenomatous hyperplasia to lung adenocarcinoma. The diversity of …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
… of vascular smooth muscle cell (VSMC) phenotypic switching is implicated in vascular disease development and VSMCs produce the majority of cells in late-stage atherosclerotic plaques. However, VSMC accumulation in mouse models of vascular disease arises from clonal expansion of very few …
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Feedback regulation in gene networks
… memory. Noise in gene expression, through the phenotypic heterogeneity it promotes, has the potential to be a mechanism implemented by cells to cope with the uncertainties in environmental conditions. By randomly expressing multiple phenotypes, each fit to a certain environment, cells can …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… results highlight the complexity of macrophage phenotypic switching and cellular dynamics in these systems. However, keratin-based therapeutics may prove useful for facilitating tissue regeneration and limiting detrimental inflammatory and cellular responses in various models of injury and …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
The phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile /differentiated state to a synthetic/ proliferative state is a hallmark of many cardiovascular diseases, driven in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in …
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Tracking profiles of genomic instability in spontaneous transformation and tumorigenesis
… basis for macro-evolutionary selection and rapid phenotypic switching in response to new environments.</p>
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Discovery and characterization of prions in Saccharomyces cerevisiae
… bistable molecular systems whose semi-stochastic switching between functional states increases phenotypic diversity within cell populations. My thesis work explores the idea that rather than being detrimental, prions may commonly act to their host's advantage. To broaden the known range of prion …
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Stochastic and physical modeling of fundamental biological processes
… a critical region of parameter space where the phenotypic switching occurs in a range seen in single molecule fluorescence studies. Stochastic simulations show induction in the looping model is preceded by a rare complete dissociation of the loop followed by an immediate burst of mRNA rather …
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THE ROLE OF CIRCULAR RNA CDR1AS IN MACROPHAGE MEDIATED CARDIAC INJURY AND REPAIR
… to the infarcted myocardium and undergo phenotypic change from pro-inflammatory (M1) macrophages in the early stage to an anti-inflammatory (M2) macrophages phenotype in the later stage, orchestrating the initiation, maintenance, and eventual resolution of the inflammatory response. …