Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Phenotypic screens"”.
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Computational analyses of small molecules activity from phenotypic screens
… screening alone to discover new drugs. Phenotypic-based screening is regaining momentum to discover new compounds since those assays provide an environment closer to the physiological state of the disease and allow to better anticipate off-target effects and other factors that can limit …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
… leading to attrition in clinical trials. Phenotypic screening has hence undergone a renaissance in both academia and in the pharmaceutical industry, partly due to this reason. One key shortcoming of this paradigm shift is that the protein targets modulated need to be elucidated …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… then present a potential solution for performing phenotypic screens at scale. In the first part, I applied single-cell RNA sequencing and analysis to human lung samples from a TB-endemic region in South Africa. Using contrastive analysis, I identify key cell populations that are differentially …
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Using Multiple Screening Strategies to Biologically and Chemically Characterize Natural Products
… This move has corresponded with a move from phenotypic screens to target based screening approaches. The perceived incompatibility of natural product libraries with target based screening efforts is often cited for these shifts. Herein we discuss the benefits of phenotypic screens and …
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Design and Synthesis of Antimycobacterial Agents
… progress has been tepid with target-based screens of synthetic and structurally conservative compound libraries failing to produce new therapeutics. This has led to a renewed interest in utilising phenotypic screens, but rather than applying them to natural product libraries and running the …
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Engineering human hepatic tissue for modeling liver-stage malaria
… stromal cells, enabling medium-throughput phenotypic screens for potential antimalarial drugs in a more authentic host cell, and demonstrated the utility of this model for malaria vaccine testing. We further hypothesized and showed that recapitulation of a more physiologically relevant …