Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"Phenotypic diversity"”.
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Adult Human Microglia: Phenotypic Diversity and Functional Complexity
… the adult human brain. This thesis explores the phenotypic diversity of microglia from adult human brain tissue – the primary microglia which are themselves part of neurological diseases. This study makes use of the unique resources of the Neurological Foundation of New Zealand Human Brain Bank …
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Molecular Analysis of Phenotypic Diversity in Human Fungal Pathogens
… by coupling high-throughput ITS1 sequencing with phenotypic analyses of fungal isolates from sputum samples. Fungal communities were not determined by clinical characteristics, but considerable phenotypic variation in traits such as antifungal resistance and morphogenesis was identified within …
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Phenotypic diversity of indigenous rhizobia nodulating different morphotypes of Vachellia karroo
… Therefore, the isolation and determination of phenotypic characteristics of indigenous rhizobia nodulating V. karroo is of paramount in improving symbiotic effectiveness and thus enhance nitrogen fixation. Four different morphotypes of V. karroo obtained from four areas of South Africa with …
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Enhancing Vallisneria americana restoration using knowledge of genotypic and phenotypic diversity
… experiments to quantify V. americana genetic diversity and differentiation at local to regional scales, evaluate evidence of local adaptation to different climate conditions, and assess evidence of inbreeding or outbreeding depression. I quantified the structure of genetic diversity in five …
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Exploring the genomic and phenotypic diversity of the Vibrio cholerae species
… However, V. cholerae is a species rich in diversity, and although much is known about the population structure of the pandemic lineages, the biology and pathogenicity of non-pandemic and non-O1 V. cholerae has been comparatively neglected. In this dissertation, I have studied the biology, …
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Genomic mechanisms underpinning phenotypic diversity in the spiral-horned antelopes (Genus: Tragelaphus)
The world is old, full of diversity, and the history of all organisms that once lived on Earth is recorded in the DNA of its descendants. The genomes of living organisms contain ancestral information that, if analyzed, reveals the underlying mechanisms to explain an organism’s evolutionary history. …
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Characterizing the genotypic and phenotypic diversity of Gardnerella vaginalis from vaginal clinical samples
… study was thus to characterize the genotypic and phenotypic diversity of G. vaginalis isolates. This was achieved in vitro, using 109 G. vaginalis isolates that were previously purified from vaginal samples of 109 French women who were BV-positive (n = 75), BV-intermediate (n = 20) or BV-negative …
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Phenotypic diversity as a tool to guide and optimize random strain improvement approaches
… many other random search-based approaches for phenotypic alteration have been developed in recent years. One such method, transcriptional engineering, relies on transcriptome-wide modifications that can be exploited to better complex traits. The initial aim of this work was to build upon the …
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Tendon Regeneration: Roles of Growth Factors and Phenotypic Diversity in Tendon Stem Cells
… Our study of TSCs lends valuable insight to the diversity of cell phenotypes found in tendon, and the potential contributions of each phenotype to tendon healing and homeostasis. These results further strengthen the status of tendon as a superior source of stem cells for tendon repair.
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Characterizing phenotypic diversity, genotype by environment interactions, and optimizing selection efficiency of a miscanthus germplasm collection
Increasing concerns over energy security and the environmental effects of conventional fuels has spurred interest in alternative avenues of energy production, with biomass feedstocks emerging as a promising source of sustainable renewable energy needs. Miscanthus is a largely unimproved crop and …
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Phenotypic diversity within two toxic dinoflagellate genera : environmental and transcriptomic studies of species diversity in Alexandrium and Gambierdiscus
… analysis, this thesis describes the genetic diversity present across dinoflagellates that produce saxitoxin, elaborating on differences in their complement of genes within the saxitoxin biosynthesis pathway. This study demonstrated retention and expression of some of these saxitoxin genes by …
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Phenotypic diversity within two toxic dinoflagellate genera : environmental and transcriptomic studies of species diversity in alexandrium and gambierdiscus
… analysis, this thesis describes the genetic diversity present across dinoflagellates that produce saxitoxin, elaborating on differences in their complement of genes within the saxitoxin biosynthesis pathway. This study demonstrated retention and expression of some of these saxitoxin genes by …
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Genetic and phenotypic diversity of bloodstream associated Staphylococcus epidermidis isolates obtained from private and public hospitals in South Africa
… to bridge this information gap, this study used phenotypic and genotypic methods to investigate the genetic diversity and genetic relatedness of bloodstream associated S. epidermidis isolates collected from private and public hospitals in Gauteng. A total of 161 bloodstream associated S. …
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Population ecology of the dinoflagellate species Lingulodinium Polyedrum in southern California
… of life cycle control and intraspecific phenotypic diversity were linked with an in situ study of the population dynamics and the intraspecific genetic diversity of this species in coastal waters of Southern California. The life cycle experiments showed that processes such as …
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The Effect of Population History on Hominoid Intraspecific Cranial Shape Diversity: Combining Population Genetic and 3D Geometric Morphometric Data
<p>Cranial shape diversity within hominoids has been previously studied with the aim of understanding how levels of diversity in extant species compare with extinct hominin specimens. This dissertation addresses the question of why cranial shape diversity differs among extant hominoids. Levels of …
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Towards a Pangenome Perspective on the Lake Malawi Cichlid Radiation
… colours, diets and behaviours. Despite this rich phenotypic diversity, past sequencing studies have shown that there is little sequence divergence between cichlids at the level of single nucleotide polymorphisms (SNPs), with a 0.1 to 0.25% pairwise divergence quoted for Lake Malawi. However, most …
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Restriction fragment length polymorphism analysis of chloroplast DNA, mitochondrial DNA, and ribosomal DNA in turfgrasses
… were used to estimate and compare the extent of diversity among the organellar and nuclear genomes, and to infer species relationships. Eight cultivated turfgrass species and subspecies were used in this study including: Festuca rubra spp, rubra, F. rubra spp commutata Gaud., F. rubra spp …
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Understanding Patterns of Phenotypic Variation in a Contemporary Population and Ancient Lineage of Fishes
… individuals in wild populations are often phenotypically diverse, exhibiting differences in many complex traits. While genetic variation undoubtedly explains some portion of phenotypic diversity in the wild, its effects can be obscured by environmental factors, which often also play a large …
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Prion biology in the context of bacteria
… units of heredity that confer unique phenotypic traits on those cells that harbor them. To date, the discovery of prions and prion-like phenomena has been confined to the Eukarya. The work presented in this thesis seeks to explore the possibility that prion-like mechanisms are …
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