Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Phenotypic Variability"”.
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Exploring the role of aneuploidy in phenotypic variability
Phenotypic variability is a noted feature of human trisomies. This is exemplified by the presentation of trisomy 21 (Down syndrome). The incidence of and severity of clinical features are highly variable in individuals with Down syndrome. These differences have long been attributed to genetic …
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On the coupling of noisy processes in biology to produce functional phenotypic variability
… Next, we demonstrate the functionality of this phenotypic variability by using the microfluidic platform to apply a short, intense period of oxidative stress. By tracking cells prior to the stress and testing for survival after the stress we reveal that $\textit{E. coli}$ prepare for sudden …
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A preliminary study of the MDH variability in Lemna minor - Lemna turionifera /
… to characterize the extent and nature of phenotypic variability. The techniques of starch gel electrophoresis were used in this investigation and. MDH phenotypes of several populations from Ontario, USA and Africa were examined and compared. Heat stability, molecular weight and cell …
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Prevalence and frequency spectra of single nucleotide polymorphisms at exon-intron junctions of human genes
… and potentially are an important source of phenotypic variability among humans. Furthermore, variation in disease susceptibility and manifestation between individuals is often associated with genetic polymorphisms that determine the way in which genes are spliced. Hence, identification of …
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Phenotypic characterization of the Peach (Prunus spp.) collection at the National Clonal Germplasm Repository in Davis, California
… research have created an urgent demand for phenotypic data in order to assist researchers in identifying relationships between genetic makeup and phenotypic variability. The peach, Prunus persica, is an important economic crop species that is heavily bred and cultivated. In peach, specific …
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Identifying the Genetic Factors in Natural Genome Backgrounds That May Modulate Phenotypic Outcomes in C. elegans
… mutations cause severe phenotypes, in others, phenotypic variability is observed. One of the factors causing this phenotypic heterogeneity is the genetic background that affects the primary mutation. This background is characterized by genetic modifiers - genes that interact and influence the …
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MULTIFACETED DRIVERS OF PERFORMANCE VARIATION IN ANIMAL POPULATIONS: INVASIVE PREDATOR, RESOURCE AVAILABILITY AND HYBRIDIZATION
… a continuous and drastic environmental change. Phenotypic variation is a key process that allow populations to withstand environmental changes by increasing survival and fitness, and can be related to both adaptations and phenotypic plasticity. For this reason, studies on phenotypic variation, …
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Investigating Roles for Cellular Heterogeneity in Cancer
… a single clone, can exhibit a high degree of phenotypic variability. However, most biological studies take measurements as averages of entire populations without consideration for the underlying distribution of cellular phenotypes. Though there is growing evidence that variability within …
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Examining the Effects of Food Supply on Eastern Oyster (Crassostrea virginica) Larval Performance and Settlement Potential in Delaware Bay and Mississippi Sound
… was modeled to reflect potential within-cohort phenotypic variability. Extended periods of suppressed salinity routinely impeded larval survival, but under adequate environmental conditions, food quality was the primary control on larval success. Reproductive seasons with favorable exogenous …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
… role in creating genomic diversity and phenotypic variability among strains of H. somni. Functional characterization of H. somni luxS in the genomic context revealed that the gene encodes S-ribosylhomocysteinase that can complement biosynthesis of AI-2 quorum sensing signal molecules in …
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Use of Inbred Strains for the Study of Individual Differences in Pain Related Phenotypes in the Mouse
A wealth of genotypic and phenotypic information about inbred strains of laboratory mice is being collected and assembled in large databases. Sophisticated mining of this information can be useful in generation of hypotheses regarding the sources and nature of phenotypic variability, both …
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Phenotypic heterogeneity and evolutionary games in microbial populations
… of the last decade is the surprising degree of phenotypic variability between individual cells in clonal microbial populations, even in identical environments. While some variation is an inevitable consequence of low numbers of regulatory molecules in cells, the magnitude of the variability is …
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Insights into the consequences of chromosome gains and losses in S. cerevisiae
… chromosome mis-segregation revealed a surprising phenotypic variability among cells harboring the same aneuploidies. Together, these results provide insights into the mechanisms for the observed consequences of chromosome gains and losses on cellular physiology.
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Population genetic studies of economically important Gracilaria and Gracilariopsis (Rhodophyta) in the south western Cape
… to taxonomists over the years in that extreme phenotypic variability in certain entities, and the occurrence of similar morphologies among different taxa (in both Gracilaria and Gracilariopsis), combine to impede species recognition. Gracilaria and Gracilariopsis occur naturally from the …
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Developmental, ecological and biological drivers of macroevolutionary trajectories of postcranial morphological diversification in bats
… I uncovered decoupled patterns of humeral phenotypic variability and scaling across foraging and roosting guilds, as well as a diaphysis-epiphyses modular partition of humeral shape variation. Overall, these results suggest a mosaic trajectory of forelimb phenotypic evolution in bats in …
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Characterisation of the Virulence and Determinants of Virulence of <i>C. Neoformans</i> var.<i>grubii</i> Genotypes from HIV Infected and Uninfected Patients in Vietnam
… Specifically, ST5 strains appear with more phenotypic variability, increased intracellular replication inside macrophages, and induction of more robust immune responses but apparent decreased virulence in mice. RNAseq profiling under log-phase growth highlights genotype-specific differential …
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The genomics behind beauty: disentangling the complex coat color genetic architecture of gir breed
Coat color in cattle is a phenotypic trait of high biological, zootechnical, and economic relevance, having historically been used as a visual criterion in selection programs and as a marker associated with adaptive and productive processes. In zebu breeds such as Gir (Bos indicus), this trait …
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Linking germination traits of oilseed rape (<i>Brassica napus</i> L.) to DNA markers
… stimuli required for dormancy break. The phenotypic traits were quantified by mathematical parameters and cultivars ranked in order of decreasing heterogeneity.<br/><br/>DNA analysis was made on leaf tissue of early, middle and late germinating phenotypes using two simple sequence repeat …
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The Evolutionary Effects of Fishing: Implications for Stock Management and Rebuilding
… success based, in part, upon individual phenotypic variability. Fishing is a source of directional selection resulting in the directed removal of some phenotypes; however, many aspects of the evolutionary effects of fishing remain have yet to be described. In order to better understand …
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