Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 3799 for “"Phenotype"”.
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Modulating macrophage phenotype for obesity therapy
… and discuss potential drug modulators of these phenotypes. Next, I investigate uptake mechanisms of dextran in inflammatory macrophages in vitro and adipose tissue depots in vivo. I determine that dextran nanocarriers of higher molecular weights (≥ 70 kDa) are well posed for specific targeting …
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Genotype and phenotype in mitochondrial disorders
… genes. We have explored genotypes and phenotypes in mitochondrial disorders considering diagnosis, natural history, and a possible treatment.
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Foundation Models for Protein Phenotype Prediction
… for modeling, generating, and predicting protein phenotypes across five interrelated knowledge domains: molecular functions, therapeutic mechanisms, disease associations, functional protein domains, and molecular interactions. To support this, we created ProCyon-Instruct, a dataset of 33 million …
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Imaging-based Phenotype for Cardiovascular Risk Assessment
… recent studies have shown that imaging-based phenotypes, such as calcification and adipose can significantly increase the power of CV risk assessment. However, the current risk factors are still not satisfactory for early and accurate prediction. This project aims to further advance this area …
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Behavioural correlates of the equine stereotypy phenotype
… but recent research has outlined a neural phenotype, relating to basal ganglia dopamine physiology, which is common to several species. One species displaying the neural and associated behavioural phenotypes is the Horse. The purpose of this thesis was to explore, through behavioural …
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Delay Discounting as a Transdiagnostic Neural Phenotype
One of the most exciting applications of clinical neuroscience is to explain and predict individual differences in psychiatric symptoms. However, reproducibility remains a central challenge to this work because studies often report conflicting results and growing evidence suggests that most …
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Familial adenomatous polyposis: a genotype - phenotype correlation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
Platelets orchestrate haemostasis through receptor-mediated adhesion, aggregation, and secretion. Platelet dysfunction can lead to bleeding and/or clotting disorders but is challenging to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated …
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Molecular Mechanism of VanB Phenotype-VanA VRE
"목적: 장구균의 vancomycin 내성의 표현형은 VanA, VanB, VanC, VanD, VanE 및 VanG의 6가지형이 있으며, 이중 VanA와 VanB형이 임상적으로 의미가 있다. VanA형은 vancomycin과 teicoplanin에 내성을 나타내며, VanB형은 vancomycin에는 내성이나 teicoplanin에는 감수성을 보인다. 그러나, 최근 vancomycin에는 내성이나 teicoplanin에는 감수성인 vanA형 vancomycin 내성 장구균(Vancomycin-resistant …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… of the inflammatory microenvironment to phenotype and progression risk. Results: A total of 2035 patients were included in the analysis. 33 genes had driver mutations in at least 5 patients, with mutations in JAK2, CALR, or MPL being the sole abnormality in 45% of the patients. The …
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Mapping Genotype to Phenotype using Attribute Grammar
… propose to model relations between genotype and phenotype using formal language theory. We use attribute grammars (AGs) to extract context-dependent information from genetic constructs and compile them into mathematical models, possibly giving clues about their phenotypes. They may be used as a …
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Benchmarking Methods For Predicting Phenotype Gene Associations
Assigning human genes to diseases and related phenotypes is an important topic in modern genomics. Human Phenotype Ontology (HPO) is a standardized vocabulary of phenotypic abnormalities that occur in human diseases. Computational methods such as label-propagation and supervised-learning address …
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Characterizing B Cell Phenotype During Chronic HCV Infection
… (APC) may contribute to the immunosuppresed phenotype. We also reasoned that direct viral interactions of HCV with immune cells may be responsible for such dysfunction. We employed a strand-specific real time RT-PCR assay and found that virus is frequently associated with B cells …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… to a distinct cell population with a stem-like phenotype that can be identified using selective markers. OS appears to follow this model where OS cells with tumor initiating potential can be identified by expression of Stro1, CD117 and embryonic stem cell transcription factors such as Sox2, …
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Phenotype and function of intestinal CD103+ dendritic cells
… of intestinal cells that differ both in phenotype and in function. Our results suggest that CD103+ DCs are the major migratory DC population in the intestinal mucosa and play a central role in initiating immune responses to luminal antigen in draining MLNs. In contrast we find that …
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scPhen: Single-Cell Phenotype Predictor for Alzheimer’s Disease
… circuitry. However, predicting patient-level phenotypes from scRNA-seq remains challenging due to limited sample sizes, variable cell counts, and the computational burden of modeling long-context dependencies. We present scPhen, a flexible, parametric deep-learning framework for phenotype …
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