Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Phenome-wide association study"”.
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Genetic Determinants of Human Susceptibility to Infections: A Multi-faceted Exome-based Analysis in the UK Biobank
… yet this area remains understudied in genome-wide association studies (GWAS), particularly in the context of exome sequencing. This thesis begins with a comprehensive literature review, which explores how advancements in sequencing technologies and analytical methods have revolutionized our …
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GENOME-WIDE ASSOCIATION STUDY OF NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS IN MASLD: EVIDENCE FROM AN ITALIAN POPULATION
… prevalent cause of chronic liver disease worldwide and a significant risk factor for cirrhosis and hepatocellular carcinoma (HCC). Despite its pathogenesis being determined by both environmental and genetic determinants, the genetic component of fibrosis progression is still only partially …
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Exploring Multivariate Gene-Environment Interactions: Models And Applications
… model can be used to test for interaction or association effects. The latter accounts for possible \newline heterogeneity in variant effects across individuals due to differences in environmental exposures, thus enabling the detection of variant effects that might otherwise be masked due to …
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Common 'Inborn Errors' of Metabolism in the General Population
… of untargeted metabolomic profiling for the study of common complex diseases, I identified candidate mediators of the association between weight gain and future type 2 diabetes risk based on untargeted, large-scale metabolomic profiling of a large prospective cohort. Integration of …