Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Phenobarbital"”.
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Phenobarbital Regulation of CYP2B2, Cyp2b10, and Cyp2b9
A new in vivo protocol, mouse tail vein injections, was developed to study PB induction of the mouse Cyp2b10 and Cyp2b9 PBRUs. In this model, the Cyp2b10 PBRU, which is 91% similar to the CYP2B2 PBRU, was induced by PB. A construct harboring the Cyp2b9 PBRU, which is 73% similar to the Cyp2b10 …
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The influence of phenobarbital on learning behavior in albino rats
LD2668 .T4 1949 W7
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Characterization of phenobarbital inducible rabbit cytochrome P450IIC4 and related genes
… in agreement with previous studies. After phenobarbital treatment, levels of P450IIC4 mRNA increased about 4-fold as measured by dot blot hybridization with a P450IIC4 specific oligonucleotide probe or by single-strand nuclease mapping of the 5$\sp\prime$ end of the mRNA. Together with the …
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Regulation of the expression of phenobarbital-inducible P450 genes / by Antony James Hansen.
Includes bibliography.
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Transcriptional regulation of basal and phenobarbital-mediated expression of rat cytochrome 2B genes
… 2B1 and 2B2 (CYP2B1 and CYP2B2) are well known phenobarbital inducible genes in rat liver. Potential transcriptional regulatory elements in the proximal promoter regions of rat CYP2B genes were analyzed by transfection in HepG2 cells and by binding of nuclear proteins. Deletion of sequences from …
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Characterization of the physical properties and the bioavailability of phenobarbital tablets, USP, 100 mg
… those drug products most often prescribed.</p><p>Phenobarbital tablets have been listed among the top 5 generic products, by new prescription volume, for the last 4 years. In addition, phenobarbital tablets have been the leading drug product amon the top 20 generic products by refill prescription …
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Phenobarbital Induced Transcriptional Activation of CYP2B Genes by Chromatin Modification at the PBRU Region
Phenobarbital (PB) is xenobiotic compound that highly induces the transcription of CYP2B genes in the liver. PB-mediated CYP2B activation is regulated by the PB-dependent enhancer (PBRU) which contains binding sites for NF-1 and two nuclear receptor binding sites (NR-1,2). A third NR site is …
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Sex-specific expression of CYP2C2 in transgenic mice and phenobarbital regulation of CYP2B by in situ injection
To study the transcriptional regulation of CYP2C2, transgenic mice were generated using a DNA fragment containing 3500bp of CYP2C2 5$\sp\prime$-flanking region fused to a luciferase reporter gene. In one of three transgenic lines, this transgene was expressed in the liver and at a lower level in …
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Transcriptional regulatory elements for basal expression and effects of phenobarbital and dexamethasone onmRNA levels of rabbit CYP2C genes
… gene is observed only after induction with phenobarbital and is confined to the liver. The CYP2C2 gene is inducible in both liver and kidney. In order to identify the DNA domains involved in the regulation of general as well as hepatic-specific transcription, 5$\sp\prime$-flanking fragments …
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Role of Cytochrome P-450 in Methemoglobin Formation by Primaquine with Hamster Liver Microsomes
… hamsters, treated before sacrificing with phenobarbital or 20-methylcholanthrene to increase the cytochrome P-450 content or with cobaltous chloride to cause its decrease. To determine the extent of induction in the liver microsomal cytochrome P-450-dependent mixed-function oxidases, …
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Studies on the induction of the hepatic microsomal mixed function oxidase system
… were injected with either 0.9 percent saline or phenobarbital. Phenobarbital increased microsomal protein, cytochrome P-450, and phosphatidylcholine in all dietary groups; however, in all groups the increase in P-450 was greater than for phosphatidylcholine. Protein deficiency (Groups 1 vs. 2) …
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Characterization of Dna Complementary to Rabbit Cytochrome P-450 Messenger-Rnas and Studies on Their Differential Regulation by Phenobarbital (Gene, Expression)
… extracts from the liver of a rabbit treated with phenobarbital. Plasmid cDNAs were selected as potential P-450 clones by plus-minus hybridization, in vitro translation of hybrid-selected mRNA, and dot blot RNA hybridization. One plasmid of 500 base pairs was selected by these techniques. A …
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Über die Beteiligung EGF-Rezeptor-vermittelter Signaltransduktionswege an den tumorpromovierenden Effekten von 2-Acetylaminofluoren, 2-Nitrosofluoren und Phenobarbital in HepG2-Zellen
… (2-AAF), 2-Nitrosofluoren (2-NOF) und Phenobarbital (PB) auf die Expression des EGF-Rezeptors (EGF-R), der Proteinkinase C (PKC), der Protoonkogene c-FOS und c-JUN in HepG2 Zellen bestimmt. Nur PB hemmte die Expression des EGF-R, wohingegen die PKC, c-FOS und c-JUN nicht beeinflusst …
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The effect of dietary zinc on induction of cytochrome p-450 by phenobarbital or 3-methylcholanthrene in male Sprague-Dawley rats
… level of induction of cytochromes P-450 or b₅ by phenobarbital or 3-methylcholanthrene. Hepatic microsomes isolated from rats that received 40mg Zn⁺² were as effective in the biotransformation of aniline, aminopyrine, or p-nitroanisole as hepatic microsomes isolated from untreated animals. The …
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ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ
… CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF "METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF "METHOTREXATE AND PHENOBARBITAL".
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Isoflurane : interaction with hepatic microsomal enzymes
… were assessed in hepatic microsomes from phenobarbital-, β-naphthoflavone- and pregnenolone-16α-carbonitrilepretreated and untreated rats. One or more of the cytochrome P-450 isozymes induced by phenobarbital and pregnenolone-16α-carbonitrile appear to defluorinate isoflurane, but those …
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The interaction of three local anaesthetic agents with hepatic microsomal cytochrome P-450
… The forms of cytochrome P-450 elevated with phenobarbital and/or pregnenolone-16α-carbonitrile were shown to play an important role in the binding of lidocaine to cytochrome P-450. Cytochrome P-448 did not appear to be involved in the binding of lidocaine to cytochrome P-450. These findings …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… exposure. The impact of four major AEDs, namely phenobarbital, valproic acid, carbamazepine and lamotrigine, on cell viability, cell cycle and differentiation of TERA2.cl.SP-12 into neurons was studied. All AEDs tested reduced differentiating stem cell viability. Valproic acid and carbamazepine …
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Characterization of the cytochrome P-450IIC3 gene and 5' flanking region of P-450IIC1
… cytochrome P-450IIC subfamily contains both phenobarbital inducible and constitutive genes. Comparative studies of the gene structures of this subfamily may shed light on the mechanism of differential induction of cytochrome P-450 genes. The purpose of this project is to characterize the …
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