Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Phencyclidine"”.
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Toxicology of phencyclidine
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Neonatal Phencyclidine (PCP) induced deficits in rats: A behavioural investigation of relevance to schizophrenia.
… thesis is to provide insights into the neonatal phencyclidine (PCP) induced deficits in male and female rats as a neurodevelopmental animal model of schizophrenia. Methods: Both male and female rats were treated with neonatal PCP on postnatal days (PNDs) 7,9 and 11 or vehicle, followed by weaning …
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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
… The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical …
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The effect of a single administration of phencyclidine on behavior and some neurochemical parameters in the rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
Clinical use of phencyclidine (PCP), a potent dissociative anesthetic, was abandoned as a result of reports of post-operative hallucinations and disoriented behavior; further, illicit use has substantially diminished because of its psychotomimetic properties. PCP intoxication in humans has also …
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Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
Phencyclidine is an N-methyl-D-aspartate receptor (NMDAR) open channel blocker that causes schizophrenia-like symptoms in healthy humans and exacerbates psychoses in schizophrenics. In animals, PCP administration to immature rats causes wide spread neuronal death during brain development and …
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Investigating Cerebellar Mechanisms of Schizophrenia by Using a Pharmacological Mouse Model: Regulation of Voltage-Gated Potassium Channels
… Kv6.4, and Kv3.1b in the cerebellar cortex of a phencyclidine-induced mouse model of schizophrenia and explores their potential role in schizophrenia symptoms. In Chapter 3 we show using immunohistochemistry that Kv2.1 is expressed in the Purkinje cells and granule cells as membrane-bound …
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Fos induction within the ventral tegmental area following infusions of phencyclidine, MK-801, and nomifensine into the core and shell subterritories of the nucleus accumbens septi
Rats learn to lever-press for phencyclidine (PCP; NMDA channel blocker and dopamine uptake inhibitor), MK-801 (NMDA channel blocker), and nomifensine (dopamine uptake inhibitor) infusions directly into the shell but not the core subterritory of the nucleus accumbens septi (NAS). PCP, MK-801 and …
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Synthetic and metabolic studies on centrally acting amines
… derived from_ the psychosis inducing agent phencyclidine [1-(1-phenylcyclohexy]l)- piperidine, PCP] has been examined in rat liver and brain subcellular fractions. In the presence of brain mitochondria this tetrahydropyridinium compound was converted to 1-(phenylcyclohexyl)- …
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Cognitive dysfunction and schizophrenia : Modelling attentional impairment with psychotomimetics. Investigating attentional impairment and structural brain abnormalities following phencyclidine administration: Enhancing translatability between preclinical and clinical tests of attention utilising the modified 5-choice task in rats - the 5-Choice Continuous Performance Test.
… with a specific focus on NMDA antagonists. Phencyclidine (PCP) was administered through a variety of treatment regimens in order to to determine the ability of inducing cognitive-specific disruptions in attentional functioning. The hypothesis that sub-chronic exposure to PCP would result in …
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Influence of physical restraint and restraint-facilitating drugs on blood measurements of white-tailed deer and other selected mammals
… (Succinylcholine chloride [SCC], RO-5-3448, and phencyclidine hydrochloride plus promazine hydrochloride [PH + P]), physical restraint, and sacrifice by shooting. Packed cell volumes (PCV) were highest in deer while manually restrained. PCV declined moderately following SCC and RO-5-3448 …
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Papain: a Novel Urine Adulterant.
… benzodiazepines, cocaine, opiates, and phencyclidine, along with gas chromatography/mass spectrometry (GC/MS) of THC-COOH and high pressure liquid chromatography/ultraviolet detection (HPLC/UV) of nordiazepam was performed in order to determine if the mechanism of urine adulteration by …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… and pelvic grooming activities, as well as phencyclidine ( an N-Methyl-D-aspartate receptor antagonist)-induced cognitive deficit. We also examined the pharmacological mechanism of these drugs on radiometric in vitro [DA] release and uptake assays and investigated whether GLP-1 can modulate …
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Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… The non-competitive NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug that has been shown to induce symptoms characteristic of schizophrenia in humans and animals. The aim of these studies was to use the sub-chronic PCP model in rats to investigate cognitive …
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Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
Phencyclidine (PCP) is a non-competitive NMDA receptor antagonist that has been shown to induce schizophrenia-like psychotic symptoms that are clinically indistinguishable from schizophrenia in patients. When administered to rodents, PCP produces an array of behaviours that are characteristic of …
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The Effects of Early Postnatal PCP Administration on Performance in Locomotor Activity, Reference Memory, and Working Memory Tasks in C57BL/6 Mice
There is a growing consensus, based on several converging lines of evidence, which suggests schizophrenia is the product of a developmental insult occurring in the late 2 nd or early 3 rd trimester. Additionally, it has been observed that adults who abuse the noncompetitive NMDA antagonist PCP …