Global ETD Search
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Showing 1 to 3 of 3 for “"PhenDC3"”.
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Exploring genetic interactions with G-quadruplex structures
… (shRNAs) whilst being treated with either PDS or PhenDC3, two independent G4-stabilising small molecules. I explored gene deficiencies that enhance cell death (sensitisation) or provide a growth advantage (resistance) in the presence of these G4-ligands. Additionally, I present a validation …
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Genetic interactions of repriming and translesion synthesis
… with the G-quadruplex-stabilising ligand PhenDC3, a result in contrast with previously observed data regarding the replication of G-quadruplex structures in the avian DT40 cell line. The growth inhibition of REV1-/- cells upon PhenDC3 treatment occurred in the apparent absence of DNA …
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RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction
… of the G-quadruplex on translation using PhenDC3 drug. The treatment of PhenDC3 drug was found to have no significant effect on the translational level. This is described in chapter 2. The presence of ribosome pauses in the upstream of G-quadruplex regions and the lack of an existing tool …