Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"Phase I clinical trial"”.
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… meningioma when administered systemically. A Phase I clinical trial was designed to evaluate the safety and preliminary efficacy of rLAS-uPA administered to dogs with presumptive intracranial meningioma. The primary endpoint was to define the safety of rLAS-uPA, as determined by serial …
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Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics
… (A-007) has recently completed a phase-I clinical trial, and objective responses were seen in advanced breast cancer, lung cancer, ovarian cancer, melanoma, skin cancer and non-Hodgkin's lymphoma. Despite the promising results in the clinical trials, the major disadvantage to using …
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The role of type I interferon in chronic lymphocytic leukemia
… autocrine IFN. Leukemic cells from patients with clinically aggressive disease expressed higher IFN receptor levels and heightened responsiveness to IFN. Enhanced IFN sensitivity was associated with chemoresistance to CLL therapies including bruton’s tyrosine kinase inhibitors such as ibrutinib …
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A Systems Biology Approach to Microbiology and Cancer
… next generation sequencing data generated for a phase I clinical trial is analyzed to determine the altered microbial community in human gut before and after antibiotic usage (Chapter 2). To our knowledge, there have not been similar comparative studies in humans on the impacts on the gut …
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
… novel therapeutic strategy for AML. Currently, a Phase I clinical trial of tigecycline in hematological malignancies is underway.
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Preparedness for end-of-life in patients with advanced metastatic cancer enrolled in a clinical trial (phase I/phase II)
… with advanced metastatic cancer enrolled in a phase I clinical trial have a life expectancy of less than nine months. Advance care planning (ACP) is a means of tailoring care to patients’ needs, especially at the end-of-life (EOL). An extensive review of literature identified a positive impact …
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A Microfluidic Approach For Investigating Thrombosis And Hemostasis: From Disease Models To Drug Testing
… pharmacological protections. Our results in a phase I clinical trial showed that cangrelor is an excellent candidate for preventing shunt thrombosis in neonatal patients after surgical operations. Using microfluidic devices, we demonstrated that thrombosis-and-hemostasis-on-a-chip could help us …
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Murine In Vitro Model Of The Blood-Brain Barrier Using A Nanofabricated Poly(Hydroxy Styrene) Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer'S Disease In Relation To Intravenous Immunoglobulin Therapy
… barrier by passive diffusion and none have been clinically useful in reversing the symptoms of the disease. Immunotherapy with intravenous immunoglobulin (IVIg) is one of several treatment strategies now being studied as part of efforts to discover safe and more effective treatment paradigms for …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… upon the PBD dimer, SJG-136, selected for clinical trials, and the novel PBD monomer compounds D709119, MMY-SJG and SJG-303. SJG-136, a novel sequence-selective DNA minor groove cross-linking agent, was shown to have potent tumour cell type selective cytotoxicity in in vitro assays. …
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Design of novel delivery systems to probe alternative routes of administration for a self-amplifying RNA rabies vaccine
… which is currently being investigated in a phase I clinical trial in humans (as of September 2019). Intradermal administration of SAM-cLNPs resulted in similar humoral and cell-mediated immune responses, while significantly weaker immune responses were achieved when administered intranasally.
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Multiple Myeloma and Its Treatment Alter Peripheral Nervous System Structure and Function
… <p>This study determined the incidence of subclinical neuropathy in multiple myeloma patients prior to receiving chemotherapy. MM patients underwent quantitative sensory testing (QST), which is a non-invasive battery of tests that provides information about the function of discrete sensory …
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Targeting the DNA damage response protein ATR kinase in pancreatic cancer
… DNA-damaging drugs and DDR-targeted agents in preclinical models of PDAC. My primary focus was on maximising the efficacy of combined ATR inhibition and gemcitabine (ATRi/gem). I hypothesised that ATRi/gem would most likely benefit specific sub-groups of patients with pre-existing aberrations in …
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Modified 3+3 Design for MTD Re-estimation
The 3+3 clinical trial design is one of the most popular dose-finding designs used in phase I oncology trials to identify the maximum tolerated dose (MTD) for new treatment regimens. While this design is widely used due to its simplicity , it has some notable limitations, including a maximum of six …
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… strategy. In particular, I will outline the preclinical and clinical development of a selective procaspase-3 activating small molecule (PAC-1) as an anticancer therapy. Activation of an executioner caspase such as caspase-3 leads to cleavage of hundreds of proteins in the cell, leading …
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Understanding and improving the anticancer activity of cisplatin
… cisplatin sensitivity in cells has useful clinical implications such as enhancing the efficacy of cisplatin chemotherapy. The results of this study led to a phase I clinical trial to investigate the efficacy of hormonecarboplatin combination therapy for treatment of ovarian cancer patients. …
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
… mainly focus on Bayesian designs for early phase clinical trials with novel target agents. It includes three specific topics: (1) reviewing novel phase I clinical trial designs and comparing their operating characteristics; (2) Proposing a Bayesian optimal phase II clinical trial (BOP2) …
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Development and evaluation of new leprosy skin test antigens as diagnostic tools
… infected individuals before the onset of clinical symptoms continues to be one of the greatest needs in the field. Preclinical diagnosis would expedite the delivery of chemotherapy to patients, prevent disabilities, decrease stigma, intercept transmission, and measure the true incidence of …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… safe and efficacious enough to be tested in clinical trials. Publication 8 and the ATS poster refer to the first development compound nominated for clinical development, D 4418. This compound demonstrated efficacy in the guinea pig lung model of airway function, eosinophil infiltration and …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… (administered as Ad.mda-7) was evaluated in a Phase I clinical trial in patients with melanomas and solid cancers. These studies document that mda-7/IL-24 is well tolerated and demonstrates evidence of significant (44%) clinical activity. This review focuses on the recent enhancements in our …
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Exploring the role of molecular imaging in the diagnosis and management of primary adrenocortical disease
… is the short half-life, restricting synthesis to clinical sites with an on-site cyclotron which amounts to <10 NHS clinical sites. To overcome this limitation, a fluorinated radiotracer will possess a significant advantage, permitting distribution of the tracer to neighbouring clinical sites as …
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