Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 500 for “"Phase I"”.
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Cluster_Based Profile Monitoring in Phase I Analysis
… Profile monitoring is conducted over two phases, labeled as Phase I and Phase II. In Phase I profile monitoring, regression methods are used to model each profile and to detect the possible presence of out-of-control profiles in the historical data set (HDS). The out-of-control profiles …
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Bayesian Phase I Dose Finding In Cancer Trials
<p>This dissertation explores phase I dose-finding designs in cancer trials from three perspectives: the alternative Bayesian dose-escalation rules, a design based on a time-to-dose-limiting toxicity (DLT) model, and a design based on a discrete-time multi-state (DTMS) model.</p> <p>We list …
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Dual-Criterion Dose Finding Designs for Phase I Clinical Trials
<p>The primary objective of Phase I oncology trials is to assess the safety and tolerability of novel therapeutics. Conventional dose escalation methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However, as cancer therapies have evolved from chemotherapy to …
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Stabilization of Soft Clay Subgrades in Virginia Phase I Laboratory Study
Many pavement subgrades in Virginia consist of wet, highly plastic clay or other troublesome soils. Such soils can be treated with traditional lime and cement stabilization methods. Alternatives, including lignosulfonates and polymers, are available, but their performance record is mixed and solid …
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Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials
… rates of clinical cancer drug development from phase I to III trials call for further improvements on novel designs, in addition to the need to promote and adopt novel designs in practice. Because anticancer agents often have a narrow therapeutic index, an accurate identification of the maximum …
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Bayesian adaptive methods to incorporate preclinical data into phase I clinical trials
… relevant information is essential in all phases of drug development. This is particularly true in early phase clinical trials, when our knowledge about toxicity of a new medicine remains limited. Thus, borrowing of information across seemingly disparate sources is appealing. Statistical …
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Evaluation of Warm Mix Additives for Use in Modified Asphalt Mixtures: Phase I
… The research effort is broken into three phases that are intended to evaluate the impacts of warm mix additives with typical polymer-modified and terminal blend tire rubber asphalt mixtures from Nevada and California: moisture damage, performance characteristics, and mechanistic …
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Novel Phase I/II Designs for Cytotoxic and Cytostatic Agents, and Combination Treatments
… Bayesian adaptive dose-finding designs for early-phase oncology trials, aiming to improve the identification of optimal biological doses (OBDs) by jointly modeling safety and efficacy. Unlike conventional Phase I designs that rely solely on binary toxicity outcomes to estimate the maximum …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
… meningioma when administered systemically. A Phase I clinical trial was designed to evaluate the safety and preliminary efficacy of rLAS-uPA administered to dogs with presumptive intracranial meningioma. The primary endpoint was to define the safety of rLAS-uPA, as determined by serial …
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Dexmedetomidine : a phase I study to evaluate the pharmacokinetics and pharmacodynamics in paediatric patients
Includes bibliographical references.
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Preparedness for end-of-life in patients with advanced metastatic cancer enrolled in a clinical trial (phase I/phase II)
… with advanced metastatic cancer enrolled in a phase I clinical trial have a life expectancy of less than nine months. Advance care planning (ACP) is a means of tailoring care to patients’ needs, especially at the end-of-life (EOL). An extensive review of literature identified a positive impact …
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Vom Antioxidanz zum Genregulator : transkriptionelle Regulation von Phase I- und Phase II-Enzymen durch Vitamin E und antioxidative sekundäre Pflanzeninhaltsstoffe
… wurden, auf die transkriptionelle Regulation von Phase I- und Phase II-Enzymen zu untersuchen. Dazu wurde die Aktivierung des PXR (pregnane X receptor) und des Nrf2 (NF-E2-related factor-2) als zentrale Transkriptionsfaktoren der Phase I- bzw. Phase II-Enzyme getestet. Der Einfluss von …
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A Phase I Dose-Escalation Study of The Braf Inhibitor Vemurafenib In Combination With The Mtor Inhibitor Everolimus In Subjects With Advanced Cancer
<p>Vemurafenib has been approved in the United States for the treatment of relapsed or refractory BRAF mutation positive malignant melanoma and is being investigated in various other malignancies. The RAS/RAF/MEK/ERK (MAPK) pathway is critical to cell proliferation in many human cancers. The mTOR …
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An Innovative Phase I Trial Design Allowing For The Identification of Multiple Potential Maximum to lerated Doses With Combination Therapy of Targeted Agents
… trial. When two drugs are combined in a phase I trial, an important trial objective is to determine the maximum tolerated dose (MTD). The MTD is defined as the dose level below the dose at which two of six patients experience drug-related dose-limiting toxicity (DLT). In phase I trials …
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A Pilot Study to Implement Phase I of Grounded Theory Data Analysis on the Influence of Facebook Communication on the Perceived Life Satisfaction of Undergraduate Students
<p>This study was an investigation of how friends’ Facebook status updates, wall posts, and pictures influence the reader’s perceived satisfaction with overall life, family, and friendships. Eleven participants were interviewed and completed a questionnaire. Open Coding of Grounded Theory research …
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Broadening The Learning Community Experience: An Outdoor Orientation Program's Impact On Engagement, Persistence, And Retention
… community for incoming freshmen consists of two phases. Phase I is as an outdoor orientation program that includes a three day, two night canoeing and camping experiencer lead by upperclassmen leaders. Faculty and staff from the institution complete every aspect of Phase I with the freshmen. …
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Basic Educational Experiences Program Utilizing Individualized Instruction in Auditory and Visual Perception Phase II
The purpose of this study was to develop Phase II in the Basic Educational Experiences Program, Phase I (6) of which was already in use in Yakima's Elementary Schools. Phase I was a minimal program in motor-sensory development. Phase II was a program in sequential perceptual activities contributing …
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