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Showing 1 to 20 of 45 for “"Pharmacy sciences"”.
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Characterizing interactions between the cellular HIV-1 integration cofactor, LEDGF/p75 with chromatin and HIV-1 integrase
Continuous emergence of HIV-1 phenotypes resistant to currently available therapies requires the need for development of new drugs with novel targets to prevent HIV-1 replication. Integration is an essential step in the life cycle of HIV-1 allowing for the stable integration of the viral genome …
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The Characterization of Dried Aluminum Hydroxide Gel Suspensions: Particle Size Analysis and Thermal Analysis
This study was performed to investigate the effect of flocculation on the sedimentation characteristics of dried aluminum hydroxide suspensions. Particle size analysis was performed using sieving, hindered settling theory and laser diffraction. Dried aluminum hydroxide suspensions were prepared in …
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A New Interfacial Cross Linking Technique: Preparation, Characterization and Evaluation of Calcium alginate Nanoparticles as a Protein Delivery System
Nanoparticles prove to be excellent carriers for site specific and/or time controlled delivery of small or large molecular weight drugs and other bioactive agents. The use of biopolymers as a natural carrier system not only makes the formulation easy but provides an additional advantage of being …
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Preparation and Evaluation of Oil-in-Water Self-Nanoemulsifying Systems with Potential for Pulmonary Delivery
Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) are mixtures of oil, surfactant and cosolvent/cosurfactant, which emulsify under conditions of gentle agitation. SNEDDS can drastically improve absorption of poorly water soluble drugs by keeping it in solubilized form at the site of absorption. …
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THE IMPACT OF CYP3A4*22 AND CYP3A5*3 ON DEXAMETHASONE AND 6-HYDROXY-DEXAMETHASONE PHARMACOKINETICS IN PHASE 1/2 CANCER PATIENTS
CYP3A4 and CYP3A5 comprise the most abundantly expressed human CYP450 activity and participate in metabolism of an estimated 40% of all marketed drugs. However, their 10-100 fold inter-individual variability in activity may have a profound effect on outcomes from drug therapy. CYP3A4*22 and …
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Synthesis of o-isotoluenes, o-quinodimethanes, and benzoenynyl carbodiimides and their cyclizations to polycyclic and heterocyclic compounds
Treatment of alkenyldicyclohexylboranes with 1-lithio-5-butyl-3,4-nonadien-1-yne, derived from 5-butyl-3,4-nonadien-1-yne, followed by trimethyltin chloride and acetic acid furnished the corresponding o-isotoluenes in a single operation. The reaction proceeded through an initial formation of …
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Solubility Improvement by Solid Dispersion and Their Characterization: Indomethacin and Phenytoin
The objective of this project was to improve the solubility of two poorly water soluble drugs, namely indomethacin and phenytoin by formulating ternary solid dispersions with a carrier and an adsorbent. Urea was used as the dispersing agent for indomethacin, while Kollidon<sup>®</sup>VA64 was used …
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Cost Utility Analysis of Balloon Kyphoplasty and Vertebroplasty in the Treatment of Vertebral Compression Fractures in the United States
Vertebral compression fractures are associated with chronic pain, decreased health related quality of life and high health care costs. Balloon kyphoplasty and vertebroplasty are vertebral augmentation procedures, widely used by spine surgeons to relieve pain in these patients. A number of studies …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
Huntington's disease (HD) is a rare, autosomal dominant, neurodegenerative disease, characterized by behavioral and cognitive deterioration, as well as a progressive loss in motor control. HD is thought to be caused by the expansion of trinucleotide, CAG, expansion at the N-terminus within exon 1 …
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Development and characterization of a novel drug dissolution test method using a quartz crystal microbalance
<p>Current dissolution apparatuses require several hundred milligrams of sample per trial, measure dissolution rate indirectly via concentration sampling, and cannot maintain sink conditions throughout the duration of a test. This work describes a novel dissolution testing methodology developed …
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Biomedical studies of single -walled carbon nanotubes using near-infrared fluorescence
Experimental studies will be described aimed at providing a scientific foundation for the use of single-walled carbon nanotubes (SWNTs) in biomedical applications. SWNTs have been found to be a unique class of nanoscale near-infrared (NIR) fluorescence contrast agents that also exhibit novel …
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Gold nanoshells for surface enhanced Raman spectroscopy and drug delivery
Gold nanoshells are tunable plasmonic nanostructures consisting of spherical silica cores wrapped with thin layer of Au. Based on the size of the Au layer with respect to the silica core, gold nanoshells can resonantly absorb or scatter light at any wavelength on the visible or infrared. On …
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Overexpression of Human Aryl Hydrocarbon Receptor in <i> E.coli</i> Using Two Different Solubility Enhancing Tags
<p>Dioxins such as TCDD are environment pollutants whose toxic effects are mediated via aryl hydrocarbon receptor (AhR) signaling pathway. AhR is a ligand sensitive transcription factor. The unbound AhR resides in cytoplasm as a complex containing p23, Hsp90 and XAP2. Upon ligand binding, AhR …
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Catalase-loaded liposomal magnesium phosphate nanoparticles for intracellular protein delivery
<p>Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. Proteins exert higher specificity and more complicated functions; they are well endured and less inclined to evoke immune responses when compared to small molecule drugs. However, exogenous …
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Computational prediction of enhanced solubility of poorly aqueous soluble drugs prepared by hot melt method
<p>Solubility is the concentration of a solute in a saturated solution at a given temperature and pressure. Solubility of a drug in aqueous media is a pre-requisite to achieve desired concentration of a drug in the systemic circulation. Low aqueous solubility is a major problem encountered with …
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Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method
<p>Solubility of active pharmaceutical agents is a crucial process that determines drug absorption and ultimately its bioavailability. Many of the new therapeutically beneficial compounds discovered are lipophilic requiring various solubility enhancement strategies to improve their solubility. …
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Apparent dissolution rate enhancement of poorly-water soluble drugs by adsorption technique
<p>Nearly 70% of the new chemical entities (NCE’s) discovered are poorly-water soluble drugs and the number of poorly-water soluble drugs are increasing rapidly in the drug discovery. Most of the NCE’s are lipophilic and have dissolution rate issues. Low dissolution rate of the drugs result in poor …
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Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism
<p>Purpose. The fate of an orally administered drug is dependent on many parameters before it can reach the systemic circulation, including drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
<p>Spray drying is widely used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and …
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Synthesis and biophysical evaluation of thiazole orange derivatives as DNA binding ligands
<p>Guanine-rich telomeric DNA at the end of chromosomes can form a unique DNA tertiary structure - G-quadruplex, which is known to inhibit the binding of telomerase to telomeric regions in cancer cells and thus regulate unrestricted cancer cell growth. Hence, G-quadruplex DNA has recently become a …
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