Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 521 for “"Pharmacy and Pharmaceutical Sciences"”.
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… (PEL), multicentric Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.</p> <p>Despite …
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Targeting Primary Cilia Immune Receptor Proteins for the Treatment of Polycystic Kidney Disease Mechanisms
… project from the cell surface of mammalian cell and play important roles in vertebrate development, organogenesis, health, and others genetic diseases. Primary cilium functions as a mechano-sensor and chemo-sensor. Defect in primary cilia causes the progression of polycystic kidney disease (PKD) …
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Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
… addition of adjuvants to boost the potency and longevity of antigen specific immune responses. At present, there is a scarcity of safe vaccine adjuvants and delivery systems that can stimulate both cellular (Th1) and humoral (Th2) immune response. Such adjuvants are required for prevention …
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Phytochemical Investigation and Drug Interaction Potential of <em>Cyanotis vaga</em>
… previously called <em>Tradescantia vaga</em> and <em>Cyanotis barbata</em>, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, <em>C. vaga</em> has been used widely for its anabolic …
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Fluorinated Organic Molecules for Medicinal Applications
… applications of fluorinated molecules in the pharmaceutical, agrochemical, and material sciences make them attractive synthetic targets. Difluoromethylation methods are of exceptional value and a limited number of techniques are available to perform that transformation. The primary method for …
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Natural Products Chemistry of Leads Acting on MRSA, HCV, Malaria, and Depression Disorders
… used for treatment of Hodgkin's disease and leukemia, digitalis from Digitalis purpurea (foxglove) for treatment of heart disease, galantamine from Galanthus caucasicus (snowdrops) for treatment of Alzheimer's disease, and paclitaxel from the bark of the Pacific yew tree to treat cancer. …
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Versatility of hot-melt extrusion for dosage form design
… Extrusion (HME) has attracted the attention of pharmaceutical companies and scientists as a technique for manufacturing a variety of dosage forms. In this research, HME was applied in different ways to achieve different goals, such as solubility enhancement, taste masking, solid state stability …
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… has attracted considerable attention in the pharmaceutical industry as an alternative processing instrument due to its advantages compared to other conventional equipment, such as economical processing, small footprint, reduced in-process times, solvent-free and continuous processing. These …
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Novel approaches to the control of infectious diseases
… against infectious diseases, several terrestrial and marine macro- and microorganisms were investigated. Several bioactive molecules, presented below, were isolated from these natural products. The mass-screening of dozens of marine Actinomycetes was completed and several Streptomyces with …
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Antimalarials from Plant Pathogenic Fungi
… describes the isolation, characterization, and biological evaluation of secondary metabolites of eight fungal strains. In addition to the antiplasmodial assay, all the extracts were subjected to phytotoxic, antimicrobial, and cytotoxic bioassays. Isolation of metabolites was performed by …
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Topical Formulation For Stimulating Sweat Secretion as an Alternative to Iontophoresis
… 400), Polyethylene glycol 200 (PEG 200), menthol and salicylic acid (SA) each at varying concentrations were screened as penetration enhancers. In vitro penetration test (IVPT) was performed on these formulations to compare the influence of these ingredients on the penetration of pilocarpine. The …
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Feasibility of AquasolveTM HPMC-AS Lg via Hot-melt Extrusion: Effect of Pressurized CO2 on Physico-mechanical Properties
… of Aquasolve™ HPMC-AS LG via hot-melt extrusion, and to examine the effect of pressurized carbon dioxide (P-CO2) on the physico-mechanical properties of Efavirenz (EFA)-loaded extrudates (EXT). EFA is as a poorly water-soluble drug and HPMC-AS LG was chosen as a carrier for this study. To optimize …
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Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology
Although salt formation is the most ubiquitous and effective method of increasing the solubility and dissolution rates of acidic and basic drugs, it consumes large quantities of organic solvents and is a batch process. Herein, we show that the dissolution rate of indomethacin (a poorly …
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Geographic and Host-Microbe Symbiotic Influence on Secondary Metabolism
… that regard the advancement to the Arctic region and the importance of host-microbe interactions in natural product discovery. Bioactive metabolites have been reported from a myriad of marine and terrestrial organisms around the world including plants, insects, sponges, tunicates, bacteria, and …
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Burden Of Depression Among Individuals With Irritable Bowel Syndrome(IBS) In The Medicaid Population
… to determine the period prevalence of IBS and comorbid depression among individuals with Irritable Bowel Syndrome (IBS) in multi-state Medicaid population, and to assess the impact of comorbid depression on healthcare utilization and costs among individuals with IBS enrolled in …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
… coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its function as a major synaptic signaling receptor, and in regards to the actions of cannabis sativa, it is the primary …
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A Novel Acetaminophen Soft-Chew Formulation Produced Via Hot Melt Extrusion With Inline Near-Infrared Monitoring As A Process Analytical Technology Tool
… suffer dysphagia when swallowing hard tablets and capsules. Gelatin based soft chewable tablets was used as an alternative and novel drug delivery format to overcome dysphagia. But conventional method of producing gelatin based soft chewable tablets has many potential issues. The objective of …
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