Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Pharmacometric"”.
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Pharmacometric modeling and simulation of ranitidine In human gastric acid secretion.
… to simulate the human gastric acid system. A pharmacometric approach places strong statistical and mathematical interpretation to characterize pharmacokinetic and pharmacodynamic behavior and to identify the patient's prognostic factors that cause changes. The pharmacometric analysis showed …
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers
… treatment approaches. In this thesis, I utilized pharmacometric modelling and data from drug-susceptible pulmonary tuberculosis patients as well as in vitro data to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of first-line anti-tuberculosis drugs and tuberculosis biomarkers. A …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
… complicate management. In this thesis, we use pharmacometric modelling and simulation approaches to tackle some of the obstacles encountered in TB and TBM treatment. Firstly, we demonstrate how pharmacometric approaches can x be useful in monitoring adherence to TB drugs. Secondly, we …
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Optimization of Lead Spectinamide Compounds as Novel Anti-tuberculosis Agents with a Pharmacometric Approach
… the further development of spectinamides using a pharmacometric approach. We have identified a lead candidate compound Lee 1599 using an iterative PK/PD approach for its pre-clinical drug development. The application of PK/PD knowledge is essential for translating the in vitro screening assay …
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A pharmacometric approach to optimal use of second line drugs for multidrug-resistant tuberculosis
Until the recent introduction of short course regimens, treatment regimens for multidrug resistant TB (MDR-TB) were long and toxic. Consequently, only approximately half of MDRTB patients completed their treatment. TB dosing guidelines have historically been unrefined with little consideration for …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
The global scale-up of tuberculosis treatment administered with antiretroviral therapy (ART) is the primary contributor to the 11 million averted deaths among individuals living with HIV observed between 2000 and 2019 in adults and children. Unfortunately, not all patients in need could fully …
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The Development of Methods to Account for Physiologic Dynamic Changes and Their Effects on the Pharmacokinetics of Therapeutic Monoclonal Antibodies and other Therapeutics
… in clearance and variability, 2) using a pharmacometric PK-ADA modeling approach to model immunology-related dynamic and variable effects on a therapeutic mAb and 3) using a systems pharmacology strategy to model the ontogeny changes in a transport protein (MRP2) and the dynamic effects on …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… alafenamide. In conclusion, by employing pharmacometric techniques, we were able to analyze and pool data from different studies, including sparsely sampled data, and run simulations to test and inform alternative dosing scenarios.
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Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis
… Altogether we suggest, the obtained results and pharmacometric model for the exposure-response relationship of lead and backup spectinamides provide a rational basis for dose selection for future efficacy studies of these compounds against Mycobacterium tuberculosis in mice and other animal …