Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Pharmacology and Toxicology"”.
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Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Protein in the Placenta: Expression, Localization and Function
… Farmaceutická fakulta v Hradci Králové Katedra Pharmacology and Toxicology Kandidát Mgr. Davoud Ahmadimoghaddam Školitel Prof. PharmDr. František Štaud, Ph.D Název disertační práce Organic cation transporter 3 (OCT3) a multidrug and toxin extrusion protein 1 (MATE1) v placentě: exprese, …
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Coffea cruda : uma releitura da matéria médica homeopática
… h aracte r istics there is also a review of the pharmacology and toxicology of the main active ingredie nt of coffee: Caffeine that acts by blocking the natural action of a chemical associated with sleep, adenosine. Recent studies reveal that a certain portion of people with insomnia symptoms has …
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
… States, with usage varying between acute (binge) and chronic (heavy usage) staging. Alcohol Use Disorders affect 14.5 million people, with 9 million men and 5.5 million women. In the case of alcohol abuse, the effect of alcohol has been very well studied on the fetus but understanding of the …
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The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
ROLE OF MAGL INHIBITION IN NICOTINE WITHDRAWAL AND REWARD. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. by Pretal Ishvarlal Patel Muldoon Director: M. Imad Damaj, PhD Professor, Department of …
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Microdialysis to study the Gastrin-ECL cell Axis in the conscious rat
… In the present study we assessed the usefulness and limitations of the technique of gastric submucosal microdialysis for the study of ECL-cell histamine mobilization in vivo. We found the microdialysis technique to be a reliable tool for the study of the ECL-cell histamine mobilization in …
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Low molecular mass proteins as markers for renal function and dialysis efficiency
… of the disease because then they can be treated and dialysis treatment can be avoided. To measure the glomerular filtration rate (GFR) an invasive technigue is used. In this thesis an equation to estimate GFR (eGFR) by drawing a blood sample and measure the concentration of cystatin C is …
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Chemical and toxicological evaluation of advanced oxidation treated pharmaceutical residues in wastewater
Contains fulltext : 311847.pdf (Publisher’s version ) (Open Access)
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
… drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to the enantiomers of …
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Tapasin - The star of the show in HLA-I maturation
… cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes peptide binding in the endoplasmic reticulum with the assistance of several other proteins …
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Developing embryo technologies for the eland antelope (Taurotragus oryx)
… studies on nondomestic bovids. The common eland is a useful model species for studies on rare tragelaphine antelopes. In Chapter 3 of the present study, effects of components/attributes of protein-free embryo culture media on the in vitro development of in vitro-derived bovine embryos were …
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Informed and Activated Patients for Medication Self-Management: eHealth-enhanced Strategies
Contains fulltext : 331746.pdf (Publisher’s version ) (Closed access)
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Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
Infection and inflammation are characterized by the release of chemotactic substances that activate cells of the immune system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and …
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Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
… process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
… thought to be the lysosomal cysteine cathepsins and legumain. Cystatin C has been considered to excert its enzyme inhibiting functions extracellularly, as a defense against enzymes from leaking lysosomes or invading pathogens. It was demonstrated by various techniques, including flow cytometry, …
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Aspects on optimisation of drug therapy in the elderly
… therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and when appropriate …
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A systematic approach to improving pharmacotherapy in the elderly
… thesis was to investigate whether a structured and systematic approach on improving pharmacotherapy in the elderly (the LIMM-model) would lead to a more appropriate and accurate drug use in the elderly. The elderly use many drugs and are more prone to suffer from adverse drug reaction. It is …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. This thesis is dedicated solely to one particular GPCR, GPR30. This receptor …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
… fluid are related to systemic levels and risk of a central nervous system (CNS) relapse, to build a population pharmacokinetic model from methotrexate concentration time data and assess how pharmacokinetic parameter predict relapse risk. An increase in serum creatinine of more than 50% …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where approximately 160 still are "orphans", meaning that …
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HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau
… human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected …
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