Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Pharmacology & Toxicology"”.
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Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience
… in three specific application domains: pharmacology and drug development, biosensors and neurotoxicology, and the study of burst and synaptic mechanisms. Chapter 1 details the testing of seven novel AChE inhibitors, demonstrating that neuronal networks rapidly detect small molecular …
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Matúš Slyško Supervisor: doc. RNDr. Jakub Hofman, PhD. Title of diploma thesis: Study of modulation of cytostatic resistance using selected targeted anticancer drugs Cancer diseases rank among the most common …
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Full of empty promises? Exploring what drug use achieves for the individual
This qualitative study begins with the research question - What does drug use achieve for the individual? For many years now, research into drug using behaviour has tended to focus on developing theories to explain why individuals use drugs, yet directly asking an individual why they participate in …
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Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study
Non-steroidal anti- inflammatory drugs (NSAIDs) have been in use for over 100 years to treat pain, exerting their analgesic effect by inhibiting prostaglandin (PG) synthesis via the COX pathway. Some of the NSAIDs have adverse side effects including ulceration of the stomach and cardiovascular …
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Discovery of acoustic emission based biomarker for quantitative assessment of knee joint ageing and degeneration
Based on the study of 34 healthy and 19 osteoarthritic knees in three different age groups (early, middle and late adulthood), this thesis reports the discovery of the potential of knee acoustic emission (AE) as a biomarker for quantitative assessment of joint ageing and degeneration. Signal …
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AUTORADIOGRAPHIC STUDIES OF THE REGULATION OF THE SUBTYPES OF THE ß ADRENERGIC RECEPTOR
The regulation of the subtypes of the ß adrenergic receptor following a number of treatment regimens was examined. Following a generalized catecholaminergic intraventricular innervation administration to of the lesion rat of CNS the by the compound 6-hydroxydopamine (6-0HDA) to adult rats, both …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
Voice disorders have a lifetime prevalence of nearly 30%, resulting in $13 billion in annual economic burden. The greatest refractory cause of dysphonia, defined as poor voice, after laryngeal injury is vocal fold (VF) scarring, which typically follows upper airway trauma or iatrogenic injury. …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
Neuroblastoma is the most common extracranial solid malignancy in children. Half of children diagnosed with neuroblastoma are considered high-risk for relapse based on clinical and tumor biological features of their tumors, and only half of high-risk patients will survive five years. Although …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
High mobility group box 1 (HMGB1) is a chromatin-associated protein that is also secreted from activated immune cells, necrotic cells, and certain cancer cells. Previous studies have described that different patterns of post-translational modification (PTM), particularly acetylation and oxidation, …
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Hair analysis for drugs of abuse
… abuse is the first step in clinical and forensic toxicology. There are a large number of controlled substances and doping agents and novel compounds, which have yet to be characterised. A series of screening methods for drugs of abuse in hair were developed using LC-MS/MS and GC-MS/MS. Using our …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
Pediatric cancers are the second leading cause of deaths in children after accidents. The last few decades have seen tremendous improvement in cancer patient survival because of development of targeted therapies. In neuroblastoma, a common childhood cancer, approval of anti-GD2 immune therapy has …
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DEVELOPMENT OF BISPECIFIC T CELL ENGAGERS TARGETING CARBONIC ANHYDRASE 9 FOR THE IMMUNE THERAPY OF CLEAR CELL RENAL CELL CARCINOMA
Advanced clear cell renal cell carcinoma (ccRCC) is responsible for nearly 70% of kidney cancers and 10,000 yearly deaths in the Unites States. While immunotherapies have demonstrated potential, poor chances of long-term survival remain for advanced cases. Yet to reach patients are bispecific T …
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The Power Output Characteristics of Downhill Mountain Biking
Purpose: To determine the performance characteristics of field-based Downhill Mountain biking (DH) and to identify the best methods of assessment for DH type activity. Methods: Twelve trained male cyclists of differing experience levels (age 31.4 ± 9.8 yrs, mean ± s.d.), performed a single …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
<p>Peptide-drug conjugates (PDCs) have emerging applications in the safer delivery of chemotherapeutics to the site of diseases to avoid the side effects associated with the drug. PDCs also improve the physicochemical property of the anticancer drug. Therefore, we have designed and synthesized …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
3,4-(±)-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a widely abused amphetamine derivative with potent stimulant properties. The neuropharmacological effects of MDMA are biphasic in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia …
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The Chemical-Induced Genotoxicity of Depleted Uranium
Uranium has been mined for many years and used for fuel for nuclear reactors and materials for atomic weapons, ammunition, and armor. While the radioactivity associated with uranium mining has been linked to the development of lung and kidney cancers, and leukemia, little is known about the direct …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
In addition to high-affinity IgE receptor (FcεRI), a subtype of mast cells (MCs) found primarily in human skin, expresses a G protein-coupled receptor (GPCR) known as MRGPRX2 (mouse counterpart MrgprB2). Following agonist stimulation, GPCRs couple to G proteins to cause cellular activation but most …
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