Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Pharmacology, Toxicology and Environmental Health"”.
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AUTORADIOGRAPHIC STUDIES OF THE REGULATION OF THE SUBTYPES OF THE ß ADRENERGIC RECEPTOR
… where only one subtype increased in density and regions where neither subtype changed. When the compound 6-0HDA is administered to neonatal rat pups on the first four days of life, a more selective lesion of the noradrenergic innervation results. Again, both subtypes of the ß adrenergic …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… from activated immune cells, necrotic cells, and certain cancer cells. Previous studies have described that different patterns of post-translational modification (PTM), particularly acetylation and oxidation, mediate HMGB1 release and confer distinct extracellular HMGB1 signaling activity. …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… VF damage, immune cells infiltrate the wound bed and secrete various cytokines, including transforming growth factor-β (TGF-β), to promote tissue repair. In response to these biochemical cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… high-risk for relapse based on clinical and tumor biological features of their tumors, and only half of high-risk patients will survive five years. Although monoclonal antibodies targeting the disialoganglioside GD2 have extended survival in neuroblastoma, relapse remains common. Thus, …
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DEVELOPMENT OF BISPECIFIC T CELL ENGAGERS TARGETING CARBONIC ANHYDRASE 9 FOR THE IMMUNE THERAPY OF CLEAR CELL RENAL CELL CARCINOMA
… is responsible for nearly 70% of kidney cancers and 10,000 yearly deaths in the Unites States. While immunotherapies have demonstrated potential, poor chances of long-term survival remain for advanced cases. Yet to reach patients are bispecific T cell engaging antibodies (BTEs) that target T cell …
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APPLICATION OF STRUCTURAL, MOLECULAR, AND PROTOEMIC STUDIES TO INVESTIGATE ON-TARGET AND OFF-TARGET MECHANISMS OF LORLATINIB RESISTANCE IN ALK DRIVEN NEUROBLASTOMA
… immune therapy has improved patient survival and discovery of anaplastic lymphoma kinase (ALK) receptor activating mutations and amplification has provided hope to further increase of patient survival. Despite this success and that of precision medicine at large, patients treated with ALK …
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Design and Sythesis of Conjugages of Amphiphilic Cell-Penetrating Peptides Containing Anticancer Drug and Ligand for Extra Cellular Matrix Biomarker to Provide Efficient Tumor-Targeting
… the anticancer drug. Therefore, we have designed and synthesized various conjugates of anticancer drugs with cancer- targeting peptides using established biomarkers of cancer such as the integrin receptor and extra-domain of fibronectin (EDB-FN) at the extracellular matrix. In the first studies, a …
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ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… but its role on the regulation of MRGPRX2/B2 and FcRI function has not been studied in detail. For the present study, we generated mice with MC-specific deletion of GRK2 and utilized GRK2 inhibitors to determine if it differentially regulates MrgprB2 and FcεRI-mediated MC activation in vitro …
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The Effects of Aqueous Atorvastatin on Steroidogenesis of <i>Xenopus laevis</i> at Environmentally Relevant Concentrations
… one of the most widely prescribed statin drugs and contamination of wastewater effluent is a growing environmental concern because of the potential to interfere with steroidogenesis in wildlife. Amphibians may be particularly susceptible to the effects of atorvastatin contamination because of …
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Role of group II metabotropic glutamate receptor subtype 2 (mGluR2) in appetitive and consummatory aspects of ethanol reinforcement
… in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in regulating ethanol (EtOH) consumption and seeking following extinction (Backstrom and Hyytia, 2005; Kufahl, et al., 2011). The sipper tube model, which allows for …
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Effects of Portuguese Man-of-War (PHYSALIA PHYSALIS) Venom on Isolated Rabbit Atria
… solution stimulates heart rate 120% (P < 0.01) and increases contraction amplitude 308% (P < 0.001). Both effects are dependent on bath concentrations of venom and calcium. The increase in contraction amplitude is significantly attenuated by diltiazem (0.8 µM) and atenolol (10 µM). Atenolol, a …
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Apical Testis Structure and the Effects of Cadmium Treatment on Spermatogenesis in Drosophila
… as a model for studying molecular, genetic and cellular aspects of human disease and physiology. Our lab has used <em>D. melanogaster</em> and related species to study the structure of the testis stem cell niche, as well as other aspects of spermatogenesis. We previously revealed a novel …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
… cells in the central nervous system (CNS) and establishes a reservoir that persists despite antiretroviral therapy (ART). Infection leads to a 30-50% risk of developing HIV-associated neurocognitive disorders (HAND), a collection of mood, motor, and memory dysfunction that can manifest …
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Flow Cytometric Analysis for Cyanobacteria in 36 New Jersey Freshwater Bodies
… accumulation of nutrients such as nitrogen and phosphorous is primarily from anthropogenic nitrogen and natural occurrences. This phenomenon causes cyanobacterial overgrowth which can potentially lead to toxic algal blooms that affect public drinking water sources and recreational usage. An …
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Mast Cell Histamine Release Induced by Portuguese Man-of-War (Physalia) Venom
<p>Richet and Portier studied the immunization of dogs against attenuated toxic extracts of the sea anemone and showed that, when given secondary injections of sublethal amounts of native toxic extracts, the dogs experienced severe pruritus and insensitivity followed by death. They called this …
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Urinary Excretion of (1-3)-Beta-D-Glucans.
… are present in the cell wall of various fungi and bacteria; they are pathogen associated molecular patterns that circulate during infection and modulate immunity. Our laboratory has previously established the pharmacokinetics of intravenously and orally administered glucans; the present studies …
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Impacts of Oil Exposure During Early Life Development Stages In Sheepshead Minnows (<i>Cyprinodon variegatus</i>) Under Different Environmental Factors
… oil spill jeopardized estuarine ecosystem health from Texas to Florida. These estuarine habitats, which serve as nurseries for many important fisheries are also prone to rapid fluctuations in environmental stressors such as oxygen concentration, and salinity. The consequence of combined …
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