Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Pharmacological agents"”.
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by neuroinflammation and demyelination. While immunomodulatory disease-modifying drugs offer relief from MS symptoms in its relapsing-remitting forms, they do not support remyelination in the …
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Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model
… added in theperfusate. Molecular and metabolic agents were administered either alone or in combination in the acute heart failure or recovery phases. Effects of glucose, insulin and sphingosine-1-phosphatewere observed on heart function, cell death and mitochondrial respiration. In the absence …
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Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents
Malaria remains a major global health problem and to date, hundreds of thousands of people die as a result of this disease every year. Malaria has been able to adapt and rebound despite various efforts made to combat the disease. The decrease in efficacy of many front-line drugs against malaria, …
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The knowledge, perception and utilisation of vitamin and mineral supplements, natural medicines and pharmacological agents as adjuncts to chiropractic practice in South Africa
Dissertation submitted in partial compliance with the requirements for a Masters Degree in Technology: Chiropractic, Durban University of Technology, Durban, South Africa, 2009.
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Modified Delphi study to determine the components of a Medical Cache required for local or international medical deployment after a major incident or disaster
… of, specifically regarding medical equipment and pharmacological agents. Methodology: A three iteration modified Delphi study was conducted over ten months. During this time selected experts who are currently working in the field of disaster response and emergency medicine, were asked to …
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Cognitive impairment: quantification and possibilities for pharmacological treatment
… to common neural substrates, and therefore pharmacological agents can be repositioned from use in neuropsychiatric to neurological disorders, and vice versa. Together, these disorders have been estimated to comprise 13% of the global burden of disease. Indeed, an individual’s ability to …
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The effects of ethanolamine and magnesium on cardiac and neurological function in isoprenaline-induced myocardial infarction and cardiac hypertrophy models in adult Wistar rats Christie Nicole Garson.
… disorders such as anxiety and depression. Many pharmacological agents have been identified to modulate MI and hypertrophy development.
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… signalling pathways by the addition of pharmacological agents to Celsior, a clinical preservation solution. Studies were conducted in an isolated working rat heart model of donor heart preservation. The first study investigated the cardioprotective effects of a novel inhibitor of …
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Screening for purine transporters in S. aureus
… by inhibiting the purine biosynthesis using the pharmacological agents methotrexate and 6-mercaptopurine and supplementing inosine monophosphate and/or guanine as an exogenous purine source. I identified an ATP-Binding Cassette transporter mutant that failed to grow under the selective purine …
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Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction
… mutants (Shaker, ether a go go) and/or pharmacological agents (4-aminopyridine) significantly decrease the high amounts of transmitter release normally observed in these situations. Significant reductions in transmitter release caused by the slo mutation are only observed at low external …
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Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery
… impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, …
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Comparative Effects of Various Drugs in Producing Vasodilatation in Peripheral Vascular Conditions
… and diagnostic effectiveness of various agents in peripheral vascular conditions has presented a real demand upon investigators and clinicians, It is apparent from the literature that no single pharmacological agent has been uniformly constant in producing the desirable effect of …
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The Neural Correlates of Future Positive Reappraisal
… stress have been treated with a diverse array of pharmacological agents and psychotherapies. Engaging in future positive reappraisal (thinking about a negative current situation in terms of producing a better future outcome of the situation) serves as a beneficial form of stress management. A …
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The Development and Use of a Color Discrimination T-Maze Learning Task in the Zebrafish (<i>Danio rerio</i>)
… a component to determine the influence of pharmacological agents on zebrafish performance in the task by examining the behavioral effects of three alcohol doses (0.0625, 0.75, and 1.5% EtOH). No significant results were found at the group level and we observed a high degree of variability …
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The effects of membrane and cytoskeletal mechanics on cell adhesiveness
… deformability, we treated cells with the pharmacological agents phalloidin, Latrinculin B, Cytochalasin D, colchicine, and Paclitaxel, which have varying effects on microfilaments and microtubules, two of the main constituents of the cytoskeleton. We found that dissolution of the actin …
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The role of Ryanodine receptors in neuronal calcium signaling
… techniques, along with well-characterized pharmacological regulators of RyRs, to better characterized the role of RyRs is our neuronal cell line model NG115-401L.</p><p>Our first main goal of this project was to develop an effective protocol that could selectively knockout or knockdown …
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Acupuncture and premenstrual syndrome
… theories has been proposed. Although some pharmacological agents have proven effective and are widely used to treat the disorder, at present there are no approved medications for this disorder. In addition, most of these agents have adverse effects which limits their use in some patients. …
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Von der Form zur Richtung
… cone turning. From experiments with several pharmacological agents it can be concluded that the protein kinase A plays a major role for the cellular responses and that the gradient steepness causes the different reactions. In cooperation with other scientists it was ruled out that the …
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Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling
… understood, making it difficult to create new pharmacological agents. With this in mind, my particular area of interest is in understanding how mechanical stimuli protects the formation of bone, leading to improved bone quality. Initially, this area was explored through use of tibial loading in …
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d-Amphetahine in Obstetrical Analgesia
… still seeks that analgesic or combination of agents which will produce sedation with adequate analgesia for the mother, and on the other hand, minimal depression of the Infant respiratory incentive. | The use of pharmacological agents in the relief of pain of labor has in recent years been …
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