Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Pharmacological activity"”.
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Synthesis and bio-pharmacological activity of antisense phosphatidyl-oligonucleotides
Lipid conjugated oligonucleotides are of great interest in the field of antisense oligonucleotides used for functional genomics, gene target validation and therapeutic pourpose. Although various lipid conjugates of oligonucleotides have already been prepared, it was not possible until now to …
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… with a slight increase in the duration of activity (90 min). With THC-Val-HS (0.6% w/v THC equivalent), drop in IOP was observed at 30 min, but the maximum drop was observed at 90 min, lasting upto 3 h (90% of the baseline). The more gradual drop in IOP can be attributed to the fact that …
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The pharmacological activity of the acidic, basic, and polar neutral fractions of marihuana whole smoke condensate alone, and in combination with, delta-9-tetrahydrocannabinol
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The synthesis and study of multimetallic Platinum Group Metal complexes as in vitro phamacological agents
… available therapies have bred a need for novel pharmacological agents. Thus, the design and study of organometallic complexes as potential chemotherapeutics may potentially identify new drug candidates. Apart from platinum based compounds, platinum-like metals such as ruthenium(II), rhodium(III) …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
… bioenergetics. It is widely accepted that pharmacological activity of certain classes of drugs (e.g. anticancer, antimalarial) is related to their ability to accept one or two electrons. However, pharmacological activity via redox cycling is an understated mechanism of toxicity associated …
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Pharmacological Investigation with Anethole in an Experimental Model of Obesity // Фармакологични проучвания с анетол в експериментален модел на затлъстяване
The thesis aims to investigate and summarise the pharmacological activity of monoterpene anethole administered orally in increasing doses to rats in a model of obesity induced by a high-calorie diet. For this purpose, 50 male Wistar rats, divided into 5 groups, consumed a high-calorie diet and were …
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INJECTABLE HYBRID HYDROGELS FOR LOCAL CHEMOTHERAPY OR TUMOR-SPECIFIC RESECTION
… to surrounded organs and enhancing the local pharmacological activity. Moreover, the use of a polymeric material, that can serve as a scaffold to deliver nanoparticles crosslinked between the network can increase the efficacy and bioavailability. For this reason, using both chemical and …
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CH activation and CH2 double activation of indolines: towards the synthesis of aspidospermidine and aspidofractinine
… are discussed in Chapter 1 together with the pharmacological activity exhibited within the Aspidosperma alkaloid series.<br/><br/>Chapter 3 details the challenges of installing the first 4 rings of the targets (the ABDE ring system). Ring expansion of a C3 cyclopropyl indolone with an imine, …
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Biosynthesis and medicinal chemistry of therapeutically promising plant natural products
… individual natural products that possess pharmacological activity from medicinal plants. While approximately 50% of all new FDA-approved small molecule therapeutics in the past 40 years were natural products or natural product analogs, challenges including limited natural resources and the …
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Design, synthesis and biological evaluation of bioorganometallic metallarectangles
… these obstacles, while further enhancing the pharmacological activity of potential drug candidates. The increased popularity and success of metal-containing compounds as pharmaceutical agents has prompted investigations into the pharmacological activity of a different class of metal-based …
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A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
… in cultures across the globe for millennia. The pharmacological activity of plants is often derived from specialized metabolites, also called natural products. Despite this wealth of medical tradition, modern medicine was unable to precisely characterize the wealth of chemistry and individual …
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QUB-1073: a bioactive peptide from the skin secretion of Phyllomedusa rohdei
… of Phllomedusa rohdei and to determine the pharmacological activity on rat uterus and urinary bladder smooth muscle. <br/>A variety of biologically active peptides, including some new antimicrobial peptides and neuropeptides, have been extracted from the secretions of frog skins. Due to the …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… these improved formulations of THC demonstrate pharmacological activity against glaucoma.
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Compositional Determinants of the Pharmacological Actions of Heparins
… (MW) and structural composition affect the pharmacological activity of heparin and its derivatives. Heparins are a mixture of glycosaminoglycans chains which are used to prevent thrombosis in a number of clinical indications. Heparins promote the inhibition of blood coagulation via their …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
… with a goal of sustaining the therapeutic activity, compared to unformulated ciprofloxacin (CPFX). However, the kinetics and mechanism of its sustained local lung retention and pharmacological activity are yet to be fully characterized. This project hypothesized that Lipo-CPFX enables …
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Dopamine Transporter (DAT) and Metabotropic Glutamate Receptor 5 (MGLU5) Irreversible Probes for Identifying Anti-Psychostimulant Therapeutics
… be derivatized, without significant loss in pharmacological activity, with a functional group capable of forming a covalent bond to their target protein and, if necessary, a tag functional group. These probes would then allow proteomic experiments to be coupled with computational modeling in …
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Dopamine Transporter (DAT), Nicotinic Acetylcholine Receptor (nAChR), and Metabotropic Glutamate Receptor 2 (mGlu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics
… without significant alteration in their pharmacological activity, with a photoreactive group capable of forming a covalent bond to their target protein and a tag for application of a "Binding Ensemble Profiling with (f)Photoaffinity Labeling (BEProFL)" experimental approach. BEProFL …
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Investigation into the Vasomotor Signs and Symptoms of the Menopause
… as well as changes in plasma and whole blood pharmacological activity were examined in post-menopausal women, at rest and during a hot flush, and in a group of pre-menopausal controls, at rest and during heat induced vasodilatation. The hot flush was found to be associated with an altered …
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Exploring the Feasibility of an Anti-Idiotypic Cocaine Vaccine
… to the brain. A possible means of negating the pharmacological activity of cocaine would be to interrupt the delivery of the drug to its receptor in the brain. Specific antibodies that bind cocaine in the blood stream may effectively prevent the drug from reaching the brain. In rodents, Carrera …
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