Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Pharmacological action"”.
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The characterisation of a fenoprofen prodrug
The term "prodrug" refers to a pharmacologically inactive compound that is converted to an active drug by a metabolic biotransformation. A nonenzymatic process, such as hydrolysis, can activate a prodrug via several routes. Prodrugs are mostly used to improve a drug's physical and chemical …
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Uso do ácido acetilsalicílico na prevenção de doenças cardiovasculares.
… compile updated information on the adoption of pharmacological therapy of aspirin in primary prevention standpoint and / or secondary CVD. The sources used for the development of the work of scientific origin in the areas of Cardiology and Pharmacology, published in the last 13 years. Studies …
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The Effects of Cannabidiol and Analgesic Expectancies on Experimental Pain Reactivity in Healthy Adults: A Balanced Placebo Design Trial
… to intoxication, analgesic expectancies, and/or pharmacological action. One approach to resolving this issue involves testing the effects of analgesic expectancies and cannabidiol (CBD), a non-psychoactive cannabinoid, on human pain reactivity using a balanced placebo design. Despite its frequent …
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Análise da eficácia e segurança do uso da cetamina endovenosa na depressão unipolar resistente ao tratamento: revisão sistemática de ensaios clínicos randomizados
… therapy. The lack of effective drugs with rapid action increases the number of cases of individuals who develop TRD. The ketamine has been increasingly studied as a therapeutic alternative Methods: Systematic Review using databases (PubMed, SciELO, LILACS e EMBASE) for the collection of …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… Val-APV) were synthesized and evaluated for interaction with efflux and influx transporters, enzymatic hydrolysis, and bioavailability. These prodrugs targeting peptide transporters were demonstrated to evade P-gp mediated efflux and exhibit better permeability characteristics compared to APV. All …
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Developmental signaling pathways in adult energy homeostasis
… homeostasis, FGF19 and FGF21 have shown similar pharmacological effects on whole body metabolism. Here, the importance of adaptive thermogenesis for the pharmacological action of FGF19 is explored. Using UCP1KO animals we show that whole-body thermogenesis is dispensable for body weight loss …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… (LOBs) are believed to impart those pharmacological activities. Previous studies have focused on the ability of flaxseed bioactives to provide their pharmacological action in the systemic circulation. However, our increasing understanding of their pharmacokinetics and chemical …
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Region-Specific Expression of Brain-Derived Neurotrophic Factor (BDNF) mRNA after Long Term Treatment with Lithium Carbonate.
… expression of BDNF for its anti-apoptosis action. RT-PCR and fluorescence in situ hybridization experiments were performed to determine the lithium-sensitive expression profile in brain and spinal cord. In the brain, chronic treatment with lithium increased mRNA expression of BDNF in the …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… few studies have investigated the biological and pharmacological action of the additional regioisomers such as EPEA epoxides, 14,15-EEQ-EA, 11,12-EEQ-EA, 8,9-EEQ-EA and DHEA epoxides, 16,17-EDP-EA, 13,14-EDP-EA, 10,11-EDP-EA and 7,8-EDP-EA. Hence, this dissertation reports the bioactive role of …
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Drug repositioning and indication discovery using description logics
… Some approaches rely on the direct physical interaction between molecules and protein targets (docking) and some methods consider more abstract descriptors, such as a gene expression signature, in order to characterise the potential pharmacological action of a drug (Chapter 1). On a fundamental …
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Meccanismo d'azione del Pramipexolo nella terapia della malattia di Parkinson
… this study was twofold: first to investigate the pharmacological action of PPX, using a unilateral model of Parkinson’s disease in which 6-OHDA was injected in the medial forebrain bundle. After two weeks, we tested in primed and naive rats, the ability of three different doses of PPX (0,035; 0,1 …
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Functional Studies of Novel Bioactives From Complex Host-Microbiomes as Drug Leads for Cancer, Infectious Disease, Depression and Pain
… the process but the definition of a mechanism of pharmacological action for a drug lead has noticeably become a higher priority. This evolution has helped diminish the stigma of natural products and compound supply issues. The issue of compound supply has also been addressed to some extent with …
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Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel
… acute toxicity studies in mice. More selective pharmacological action is generally associated with decreased toxicity, but also with increased vulnerability to resistance. This creates an important question. Would a less toxic AmB derivative still evade drug resistance? The AmB urea derivatives …
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An Investigation of the Health Benefits of Honey as a Replacement For Sugar In the Diet
… including slower uptake into the bloodstream, a pharmacological action of reducing blood glucose levels and a high level of bioavailable antioxidants, all of which may mean that honey could be less harmful to health than sucrose in the diet. This study was therefore designed to investigate the …