Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 145 for “"Pharmacological Inhibition"”.
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… enzyme (ACE) production may be enhanced during pharmacological inhibition of the enzyme. Little is known, however about the mechanism of this induction. After demonstrating increases in circulating ACE protein in cardiac failure patients receiving the ACE inhibitor captopril, a rat model was …
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Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
… mutations that determine sensitivity to mTOR inhibition and suggest a novel therapeutic anticancer strategy.
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… target. Our lab’s past work has shown that pharmacological inhibition or gene silencing of LSD1 slowed DMG cell growth. However, while pharmacological inhibition of LSD1 is promising, further optimization is needed to mitigate any off-target effects that may alter drug response and impact …
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In vitro pharmacological inhibition of myofibroblast differentiation and force generation in a collagen-GAG matrix
… of fibroblasts make it an attractive target for pharmacological inhibition. A preliminary in vitro study was conducted to evaluate the effect of Y-27632, a specific pharmacological inhibitor of ROCK, on the contraction of highly porous, three-dimensional type I collagen- glycosaminoglycan (CG) …
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Discovery and Effects of Pharmacological Inhibition of The E3 Ligase Skp2 By Small Molecule Protein-Protein Interaction Disruptors
<p>Skp2 (S-phase kinase-associated protein 2), one component of the SCF E3 ubiquitin ligase complex, directly interacts with Skp1 and indirectly associates with Cullin1 and Rbx1 to bridge the E2 conjugating enzyme with its protein substrate to execute its E3 ligase activity. Skp2 is an Fbox protein …
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Pharmacological inhibition of CK2: the effect of an FDA designated orphan drug on pathology, neuroinflammation, and glial phenotypes in Huntington’s disease
Huntington’s disease (HD) is a devastating autosomal dominant neurodegenerative disease that manifests with progressive motor, cognitive, and psychological impairments. HD is caused by a polyQ (CAG) repeat expansion in the huntingtin (HTT) gene, leading to the misfolding and aggregation of mutant …
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The investigation of the genetic and pharmacological inhibition of striatal-enriched protein tyrosine phosphatase (STEP) and its role in hippocampal excitability and seizure propensity
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Mediodorsal thalamus contributes to the timing of instrumental actions
… MD on interval timing, localized and reversible pharmacological inhibition was done. Mice were trained across multiple timing paradigms in order to assess the generality of MD involvement in timing using an operant 30s peak-interval (PI) procedure as well as a 10s head-fixed (HF) task. …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
… STAT3 activation dynamics and effects of its inhibition on infection. STAT3 phosphorylation and nuclear translocation were detected beginning 48 h post-infection, coinciding with upregulation of STAT3 target genes, including the anti-apoptotic gene MCL1. Pharmacological inhibition of STAT3 …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… fibrosis under pressure overload, and whether pharmacological inhibition of PIEZO1 signalling could offer therapeutic potential. To address these aims, I generated fibroblast-specific Piezo1 conditional knockout mice and performed transverse aortic constriction, echocardiography, invasive …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
… in response to cytokine stress. Furthermore pharmacological inhibition and siRNA-mediated knockdown of JNK in beta cells also attenuated HSP90 release in response to cytokine stress. Pharmacological inhibition of HSP90 chaperone function exacerbated islet cell stress during the development of …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… and autophagy. Both genetic silencing and pharmacological inhibition of ESRRA with the inverse agonist XCT-790 significantly reduced Gb3 accumulation in both CLN3 and CLN7 disease models, suggesting that ESRRA may represent a novel therapeutic target for multiple BDs. Transcriptomic …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
… rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in lymphocytes had been described, it remained unclear if Abl kinases regulate innate immune function. To …
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… with potent stimulant properties. The neuropharmacological effects of MDMA are biphasic in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as …
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Host Modulators of the Death Response to Influenza A Infection
… deflect host cell suicide checkpoint activation. Pharmacological inhibition of representative targets, RGGT and CHEK1, resulted in significant protection against infection of human epithelial cells by the A/WS/33 virus. In addition, chemical inhibition of RGGT partially protected against H5N1 and …
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Chemical Biology Approaches to Interrogate Heat Shock Transcription Factor 1 Regulation in Cancer
… small-molecule HSF1 inhibitor. The pharmacological inhibition of HSF1 occurs through small-molecule stimulation of nuclear, but not cytoplasmic HSF1 degradation, which attenuated prostate cancer cell proliferation, inhibited the HSF1 cancer gene signature and arrested tumor …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… 2, the TrkB receptor as a potential target for pharmacological modulation is examined. Its signaling, role in brain disease, and reported agonists and antagonists are reviewed. In addition, our attempts at establishing an assay to assess TrkB activation, as well as our results using the reported …
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Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
… macrophage death resulting in granuloma failure. Pharmacological inhibition of cell death pathways associated with mycobacterial infection did not influence uxt mutant susceptibility to infection, suggesting that uxt deficiency results in a novel form of death in mycobacterium-infected macrophages.
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The role of ceramides in cigarette smoke-induced alveolar cell death
… weeks the de novo- ceramide synthesis pathways. Pharmacological inhibition of acid sphingomyelinase significantly attenuated CS-induced apoptosis. To understand the mechanisms by which ceramides induce apoptosis, we investigated the cell types affected and the involvement of RTP801, a CS-induced …
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Exploring the Functional Interaction Between CaMK-II and p53
… with previous studies in mouse fibroblasts with pharmacological inhibition. p53-deficient cells were less sensitive to CaMK-II deficiencies using dominant negative CAMK-II, but not pharmacological disruption. The overall results of this study have provided significant clues to the mechanism …
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