Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Pharmacokinetics and Pharmacodynamics"”.
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
… is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to …
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Pharmacokinetics and Pharmacodynamics of Theophylline in Ruminating Calves
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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Pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds
The aims of this thesis were to investigate the pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds. For decades, the inflammatory process and the properties of the NSAIDs have been extensively investigated in humans and other species. However, current knowledge …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically whether the lack of late efficacy of local delivery of angiogenic factors could be explained by a comprehensive understanding of local pharmacokinetics (PK) and …
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Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of Statins
Statins are regular and universal medications for preventing cardiovascular disease and hyperlipidemia. Despite their effectiveness, statin response varies significantly between individuals, which can be attributable to a number of genetic factors and personal medication habits. This thesis aims to …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in TB/HIV coinfected patients recruited in two phase III clinical trials (61 patients in TB-HAART and 222 patients in RAFA study) were described using nonlinear mixed-effects modelling. Concentration-time data for rifampicin …
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… anti-craving effect with both alcohol addiction and cocaine dependence. Inhibition of ALDH2 cannot explain disulfiram's efficacy in cocaine dependence. The disulfiram metabolite S-(N, N-diethylcarbamoyl) glutathione (carbamathione) is formed from disulfiram and appears in the brain after the …
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Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study
… their analgesic effect by inhibiting prostaglandin (PG) synthesis via the COX pathway. Some of the NSAIDs have adverse side effects including ulceration of the stomach and cardiovascular events which are associated with bleeding. Search is still going on to find a safe NSAID. Two new coxib …
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Dexmedetomidine : a phase I study to evaluate the pharmacokinetics and pharmacodynamics in paediatric patients
Includes bibliographical references.
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of nitrofuranylamide lead compounds suitable for further development. </p> <p> First, we examined the biopharmaceutic properties and preclinical PK of …
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The pharmacokinetics and pharmacodynamics of oral ponazuril in the treatment of systemic isosporosis in passerine birds
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Chirality in clinical pharmacology : studies with ketoprofen / by Peter John Hayball.
… aspects of the potential enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in humans, and develops methods for quantifying total (bound plus unbound) and unbound ketoprofen enantiomers in plasma.
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Vasoconstrictors used in dentistry
… the study shows. The knowledge of the chemistry, pharmacokinetics and pharmacodynamics is essential in the bank of knowledge of the dentists and is key to learn and understand to those upcoming dentists, without which, the healthcare in society can be neglected and can cause grave complications.
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Analysis, pharmacokinetics, metabolism and pharmacodynamics of labetalol in pregnant and nonpregnant sheep
Labetalol, a combined al and p-adrenoceptor blocker, is used as an antihypertensive, especially in the management of hypertensive disorders in pregnancy. While the antihypertensive efficacy of labetalol in pregnancy has been assessed by a number of clinical trials, there is little information in …
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Paediatric Dexmedetomidine Pharmacology
… setting, but without the concomitant understanding of the pharmacokinetics and pharmacodynamics to ensure safe and effective dosing. In this thesis the pharmacokinetics and pharmacodynamics of dexmedetomidine in children after cardiac surgery were explored. The maturation of dexmedetomidine …
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Sedation in paediatric intensive care
Paediatric intensive care is an expanding specialty that has been shown to improve the quality of care provided to critically ill children. An important aspect of the management of critically ill children includes the provision of effective sedation to reduce stress and anxiety during their stay in …
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A pharmacokinetic and pharmacodynamic study of pioglitazone in a model of induced insulin resistance in normal horses
… characterized by adiposity, insulin resistance, and an increased risk of laminitis. Reducing insulin resistance may decrease the incidence of laminitis in horses with EMS. Pioglitazone, a thiazolidinedione class of anti-diabetic drug, has proven efficacy in humans with type 2 diabetes, a syndrome …
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