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Showing 1 to 2 of 2 for “"Pharmacokinetics Mathematical models"”.
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A multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracil
… of intensive quantitative compartment models that predict the time course of 5-FU and DHFU in the body using the Runge-Kutta fourth order method. The parameters within our system of nonlinear differential equations were determined by fitting the models to the clinical data. We showed …
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Evaluation of bootstrapping as a validation technique for population pharmacokinetic models
… and others that the population pharmacokinetic models (PPKM) need to be validated. This is particularly true when the model plays a key role in the construction of dosing strategies. It was the objective of the current study to evaluate the ability of bootstrapping to identify PPKMs that were …