Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Pharmacokinetics/Pharmacodynamics"”.
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Evaluation of the pharmacokinetics, pharmacodynamics, and safety of enrofloxacin administration to pregnant mares
… potential toxic effects on the fetus, the pharmacokinetics and pharmacodynamics of the enrofloxacin in both the intravenous form and a newer oral form were evaluated in the pregnant mare. After determining the optimal dose, and a higher dose that might be used to treat intermediately …
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Model-Informed Drug Development of Riluzole for Neuroprotection in Acute Spinal Cord Injury: Integrating Pharmacokinetics, Pharmacodynamics, and Clinical Outcomes for Precision Medicine
… model-informed framework that incorporates pharmacokinetics, pharmacodynamics (PD), and clinical outcomes (CO). By leveraging modeling and simulation, this approach provides a strategy to address clinical heterogeneity and guide individualized treatment based on drug exposure, biomarker …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… study was to determine the safety, tolerability, pharmacokinetics, pharmacodynamics as well as in vitro metabolism and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in …
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MODELING AND MINING ANTIMICROBIAL RESISTANCE IN HUMAN AND ANIMAL POPULATIONS
… have been collected on antimicrobial use, pharmacokinetics, pharmacodynamics, resistance genes, and resistance phenotypes over several decades. Novel and innovative methodologies are required to maximize the utility of these data and improve our understanding of antimicrobial resistance …
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Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials
… through subsequent confirmatory trials. Since pharmacokinetics/pharmacodynamics (PK/PD) information reflects partially drug exposure and drug-receptor interactions, incorporating this information in phase I trial design may improve the efficiency of the MTD identification. Moreover, the …
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Effect of obesity on hepatic drug metabolism
… the lack of knowledge regarding changes in the pharmacokinetics (PK) of therapeutic agents in obese individuals. Thus the aim of this thesis was to determine the effect of obesity on drug metabolism and evaluate methods that could potentially predict changes in pharmacokinetics in the obese …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… and can be major determinants of drug pharmacokinetics, pharmacodynamics and toxicity. In contrast to drug metabolizing enzymes, which mainly concentrate in the liver and small intestine, drug transporters are expressed ubiquitously throughout human body. In human kidney, drug …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… studies are warranted in target identification, pharmacokinetics/pharmacodynamics, and more thorough in vivo mechanism examinations to eventually uncover the therapeutic value of C150 and shed more light on our understandings on inhibiting cancer cell EMT and enhancing ER stress to …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… cancer management. More studies on the pharmacokinetics, pharmacodynamics, and the combination of KH-3 with conventional chemotherapeutic agents are worth investigation. We hope that the work we have accomplished in this dissertation could add to our knowledge of a new mechanism on EMT …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active ligand of vitamin D receptor (VDR), is useful for the prevention and treatment of various diseases, including chronic kidney disease (CKD), cardiovascular disease, hypercholesterolemia and neurodegenerative diseases. However, the therapeutic …
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Pharmacological characterisation of selected pyrrolobenzodiazepines as anti-cancer agents. Pharmacokinetic and pharmacodynamic characterisation of the pyrrolobenzodiazepine dimer SJG-136 and the monomers D709119, MMY-SJG and SJG-303
… IC50 values. Furthermore, SJG-136 showed linear pharmacokinetics over a 3-fold drug dose range. Metabolism studies showed SJG-136 is readily metabolised in vitro by hepatic microsomes, predominantly to a monodemethylated metabolite; this metabolite could be detected in vivo. Analytical method …
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Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of Statins
… aims to review the genetic factors affecting the pharmacodynamics and pharmacokinetics of statins.
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Evaluation of rationality and risks of pharmacotherapyin older patients in long-term care facilities
Záměr Hlavními cíli této disertační práce bylo zhodnotit dostupné informace týkající se farmakologických vlastností benzodiazepinů a jejich změn vlivem stárnutí organismu; zhodnotit prevalenci použití benzodiazepinů u geriatrických pacientů v léčebnách pro dlouhodobě nemocné; analyzovat vztah mezi …
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Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
Hintergrund: Beim Konsum illegaler Drogen steht Cannabis (Hauptinhaltstoff Delta-9-THC) seit über 30 Jahren auf Platz eins in Deutschland und Europa. Des Weiteren wird THC in der Medizin zunehmend auch therapeutisch eingesetzt und ist heute Gegenstand zahlreicher Studien. Methoden: In dieser Studie …
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IN-VITRO PK/PD PROFILING AND MODELING OF THE ANTI-SICKLING AGENTS, 5-HYDROXYMETHYL FURFURAL (5-HMF) AND NOVEL SYNTHETIC ALLOSTERIC EFFECTORS OF HEMOGLOBIN (AEH) IN HUMAN WHOLE BLOOD
<p>Introduction. 5-HMF and novel INN-compounds are left-shifting AEH, shown to have anti-sickling action by forming transiently covalent Schiff-base adducts with hemoglobin (Hb), thereby increasing the Hb O2-affinity. They are hypothesized to be substrates for aldehyde dehydrogenase (ALDH) in the …
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… metoprolol induced by sarpogrelate. However, the pharmacodynamics of metoprolol did not differ significantly among the three treatment groups. Sarpogrelate and M-1 were potent and selective competitive inhibitors of CYP2D6 in vitro. Especially, inhibition of CYP2D6 by M-1 was ten-fold more potent …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
Prostate cancer is the most common type of cancer and the second leading cause of cancer related deaths in men in the United States. According to the National Cancer Institute (NCI), 238,590 new cases with deaths of 29,720 from prostate cancer have been estimated for 2013. Diethylstilbestrol (DES) …
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of nitrofuranylamide lead compounds suitable for further development. </p> <p> First, we examined the biopharmaceutic properties and preclinical PK of …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
… with Pheroid® technology to determine the pharmacokinetics and pharmacodynamics of goserelin after administration of an oral dose of a novel pro-Pheroid®-goserelin formulation, in comparison to the existing goserelin subcutaneous implant (Zoladex®) in male and female BALB/c mice. The …
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