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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 55 for “"Pharmacokinetic Parameters"”.

  1. The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling

    Valodia, PraneetDivision of Clinical Pharmacology1995

    The pharmacokinetics of phenytoin is complicated by the nonlinearity of the dose-concentration relationship which is a consequence of capacity-limited metabolism. Individualized therapy with phenytoin is therefore optimally required. As no data are available on the population pharmacokinetics of …

    cape-town Repository record

  2. The first-pass extraction of pindolol in comparison with propranolol in rat liver

    Basset, Helen MargaretDivision of Clinical Pharmacology1979

    … comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by means of an isolated rat liver perfusion model.

    cape-town Repository record

  3. Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria

    Anyorigiya, Thomas AtinganeDivision of Clinical Pharmacology2017

    … method was successfully used to describe the pharmacokinetics of amodiaquine and desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria, who were followed up for 28 days in a therapeutic efficacy study of the fixed-dose combination therapy, artesunate-amodiaquine. …

    cape-town Repository record

  4. Pharmacokinetic Studies and Tissue Residue Analysis of Oxytetracycline in Summer Flounder (Paralichthys dentatus) Maintained at Different Production Salinities and States of Health

    Hughes, Kathleen PowersVirginia Tech2003

    … experiments were conducted to investigate: 1) pharmacokinetic parameters of oxytetracycline (50 mg/kg) following intravascular (IV), intraperitoneal (IP), intramuscular (IM) and per os (PO) administration in summer flounder maintained at 28 ppt salinity and 20°C; 2) pharmacokinetic parameters …

    vt Repository record

  5. Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis

    Wagh, Santosh Janardan2022

    … backup spectinamide, respectively. The dedicated pharmacokinetic studies with a collection of series of blood samples were conducted in healthy animals. Population pharmacokinetic analysis was performed using non-linear mixed effect modeling to estimate pharmacokinetic parameters in healthy …

    tenn-hsc Repository record

  6. Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV

    Mondleki, EnkosiDepartment of Medicine2022

    … for dose optimisation. Aims: We compared the pharmacokinetic parameters of dolutegravir in Southern African adults living with HIV with and without obesity. Methods: Blood samples were collected at various time points over a 24 hour-period for dolutegravir assays. Non-compartmental analysis …

    cape-town Repository record

  7. ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ

    Πρωτόπαπα, ΦωτεινήNational and Kapodistrian University of Athens1986

    THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. …

    greece Repository record

  8. Metabolism And Pharmacokinetics In The Development Of New Therapeutics For Cocaine And Opioid Abuse

    Vuppala, Pradeep Kumar2019

    … is focused on the role of metabolism and pharmacokinetics in the development of new pharmacotherapies, CM304 (sigma-1 receptor antagonist), mitragynine and 7-hydroxymitragynine (μ-opioid receptor agonists), for the treatment of drug abuse. The affinity of cocaine to sigma-1 receptors …

    mississippi Repository record

  9. Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach

    Chung, Eun Kyoung

    … problem and has been associated with altered pharmacokinetics and pharmacodynamics of many drugs. However, little is known regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, …

    purdue-thes Repository record

  10. Population pharmacokinetic models describing drug-drug interactions and variability in HIV infected South Africans on protease inhibitor-based antiretroviral regimens with and without tuberculosis

    Chao, ZhangDepartment of Medicine2012

    … were designed to characterize the population pharmacokinetic parameters of lopinavir and ritonavir in HIV infected South Africans, to account for the drug-drug interactions between lopinavir, ritonavir and rifampicin, to investigate optimal dose regimens of lopinavir/ritonavir when …

    cape-town Repository record

  11. A Meshless Approach to Computational Pharmacokinetics

    Khoury, Anthony Matthew

    … with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model …

    embry-riddle Repository record

  12. Characterization and Pharmacokinetics of Rifampicin Laden Carboxymethylcellulose Acetate Butyrate Particles

    Casterlow, Samantha AlexandraVirginia Tech2012

    … particle formulation techniques. In vivo pharmacokinetic studies in BALB/c mice indicate that a single dose of rifampicin laden CMCAB spray dried particle formulations are able to improve pharmacokinetic parameters including relative bioavailability of rifampicin compared to that of the …

    vt Repository record

  13. Dynamic Contrast-Enhanced MRI and Diffusion-Weighted MRI for the Diagnosis of Bladder Cancer

    Nguyen, Huyen ThanhThe Ohio State University2013

    … results demonstrated that the maps of DCE-MRI pharmacokinetic parameters can better visualize small malignant tumors and the tumors within bladder wall thickenings to improve the detection of bladder cancer compared to conventional T2-weighted MRI alone. Twenty-five patients were included in …

    ohiolink Repository record

  14. Dynamic Contrast-Enhanced MR Microscopy: Functional Imaging in Preclinical Models of Cancer

    Subashi, Ergys2014

    … for monitoring tumor response to therapy. The pharmacokinetic parameters derived from this technique have been used in more than 100 phase I trials and investigator led studies. The simultaneous challenges of increasing the temporal and spatial resolution, in a setting where the signal from the …

    duke Repository record

  15. Paediatric Dexmedetomidine Pharmacology

    Potts, AmandaResearchSpace@Auckland2010

    … but without the concomitant understanding of the pharmacokinetics and pharmacodynamics to ensure safe and effective dosing. In this thesis the pharmacokinetics and pharmacodynamics of dexmedetomidine in children after cardiac surgery were explored. The maturation of dexmedetomidine …

    auckland-ms Repository record

  16. Application of population pharmacokinetic-pharmacodynamic modelling evaluate and optimise aminoglycoside therapy in patients with cystic fibrosis

    Alghanem, Sarah Salah AbdullahUniversity of Strathclyde2013

    … The focus of this thesis was to use population pharmacokinetic methodologies to examine how aminoglycoside pharmacokinetic parameters change over time in this group of patients and to develop and evaluate dosing regimens and data interpretation methods. A population pharmacokinetic analysis was …

    strathclyde Repository record

  17. A study of pharmacokinetics of anti tuberculosis drugs in Zambian PTB patients co-infected with the Human Immuno-Deficiency Virus

    Lakhi, Shabir2012

    The present study assesses the pharmacokinetic parameters for rifampicin, isoniazid and pyrazinamide in Zambian PTB patients with HIV at the University Teaching Hospital, Lusaka, Zambia. The assaying of the drugs was done at the University College London Medical School.To determine whether the …

    zambia Repository record

  18. Polymerní terapeutika pro imunoonkoterapii

    Kashmel, PavelUniverzita Karlova, Přírodovědecká fakulta2022

    … drug transport to tumor tissues. Improved pharmacokinetic parameters of the prepared polymeric systems carrying ZM241385 should be the basis for increased therapeutic activity of the polymeric nanosystem in tumor immunotherapy. Polymeric precursors were synthesized by controlled RAFT …

    charles-prague Repository record

  19. Pharmacokinetics and pulmonary distribution of Draxxin® (tulathromycin) in healthy adult horses

    Leventhal, Hannah RaniVirginia Tech2021

    The objective of this study was to determine the pharmacokinetics and tolerance of tulathromycin (Draxxin®; 2.5 mg/kg once) after intramuscular (IM), subcutaneous (SC), and slow intravenous (IV) administration to six adult horses. A three-phase design and 4-week washout period were used. Drug …

    vt Repository record

  20. Lignocaine extraction ratio and clearance as an indicator of hypoxic hepatic injury : a study using the in situ and the isolated perfused pig liver

    Mets, BerendDivision of Clinical Pharmacology1992

    … after bolus dose administration the necessary pharmacokinetic parameters to achieve similar constant hepatic affluent lignocaine concentrations in vivo and in the isolated preparation could be determined. The preliminary investigations showed that a sequential experiment using the same liver to …

    cape-town Repository record

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