Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Pharmacognosy"”.
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Pharmacognosy of the Saururaceae : microscopy of powdered drugs
<p>Plants of the family Sauruaceae are used in folk medicine in various parts of the world. Chemistry of some plants of this family and their chemotaxonomy has been investigated in our laboratory (12).</p> <p>It is very difficult to establish identity and authenticity of commercially available …
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Mass Spectrometric Interrogation of Thioester-Bound Intermediates on Nonribosomal Peptide and Polyketide Assembly Lines
… has been attained by intersecting interests in pharmacognosy with enzymology and by pushing the limits of current analytical technologies. Further, this research has solidified an intellectual framework to enhance the bioengineering of novel catalysts for creation of new biologically relevant …
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The effect of selected colonic metabolites of polyphenols on the copper-triggered Fenton reaction and hemolysis
… of Pharmacy in Hradec Králové Department of Pharmacognosy and Pharmaceutical Botany Supervisors: PharmDr. Zuzana Lomozová, Ph.D., Assoc. Prof. Laura Mercolini, Ph.D. Consultant: Dr. Michele Protti, Ph.D. Candidate: Magdalena Walková Title of the diploma thesis: The effect of selected colonic …
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Natural product chemistry in drug discovery
… The third addresses source verification in pharmacognosy. It demonstrates that furanocoumarins previously reported from Cicerbita alpina originated instead from Peucedanum ostruthium roots present in a mixed plant collection, correcting the phytochemical record and preventing the …
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Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves
<p>Red maple (<em>Acer rubrum</em>), also known as swamp, water or soft maple, is endemic to eastern and central North America and was widely used as traditional medicine by the first peoples. Commercially, its well-known products include maple syrup and high-quality lumber. The potential medicinal …
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An assessment of medicinal hemp plant extracts as natural antibiotic and immune modulation phytotherapies
This study aimed to evaluate the antimicrobial efficacy of medicinal hemp plant extracts to determine the antibacterial effects of indigenous Sansevieria species and exotic Cannabis sativa phytotherapy varieties. This study also assessed whether aqueous o
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Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development
<p>Prenyltransferase (PT) biocatalysts are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors. This prenyl modification in small molecules leads to changes in structural and biological …
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The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds
<p><strong>Background</strong>: Carum carvi (caraway) of the Apiaceae family has been used in many cultures as a cooking spice and part of the traditional medicine. Previous reports primarily focus on the medicinal properties of caraway seed essential oil and the whole seeds extract. However, no …
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Kinetic studies of the spasmogenic effects of serotonin and isolates from Byrsonima crassifolia leaves on rat fundus
<p>Leaf and bark extracts of a Mexican medicinal plant, Byrsonima crassifolia (Malpighiaceae), exhibited spasmogenic effects on isolated rat fundus and biphasic effects on jejunum and ileum. Preliminary evaluations using rat fundus in Krebs solution indicated that the activity of a 2% acetic acid …
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
<p>Trachyspermum ammi, commonly known as ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the …
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Συμβολή στη φαρμακογνωστική αξιολόγηση του Sideritis clandestina
Το γένος Sideritis (οικογένεια Lamiaceae) περιλαμβάνει πάνω από 150 είδη παγκοσμίως· στην Ελλάδα ευδοκιμούν 16 taxa. Αν και έχουν διεξαχθεί μελέτες της χημικής σύστασης ορισμένων, υπάρχουν ακόμα taxa που δεν έχουν μελετηθεί επαρκώς, όπως το φυτό S. clandestina ssp. peloponnesiaca, το οποίο είναι …
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Evaluation of Anthelmintic Properties and Toxicity of Pure Compounds Isolated from Dalea Spp (Plantae, Fabaceae)
Infecting upwards of a billion people worldwide, hookworm is one of the most prevalent parasitic infections affecting the world today. Those infected experience hookworm disease, characterized by severe anemia, which can lead to malnutrition, low birth weights, and physical and mental impairments. …
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Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
<p>Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde <b>2</b> and 2,3-dibromo-4,5-dihydroxybenzaldehyde <b>5</b> together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde <b>3</b> and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene <b>9</b>, …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, …
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Development of Tools to Assess the Effects of Lunasin on Normal Development and Tumor Progression in Drosophila Melanogaster
<p>Soy contains many bioactive molecules known to elicit anti-cancer effects. One such peptide, Lunasin, has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. In this study we attempt to understand the …
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Vascular receptor changes in ischemic stroke
The present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating …
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