Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Pharmacogenetics"”.
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Pharmacogenetics : ethics and public policy
… and drug response, it was only recently that pharmacogenetics has been introduced as a new paradigm for drug development and optimum use. Associating the various genetic variations from clinical phenotypes may not be so direct. Moreover, challenges for future pharmacogenomics and its …
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Pharmacogenetics to optimize the treatment of Major Depressive Disorder
Contains fulltext : 317866.pdf (Publisher’s version ) (Open Access)
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Efavirenz pharmacogenetics and metabolic toxicity in black South Africans
Background: Efavirenz is associated with hepatotoxicity, dyslipidaemia and dysglycaemia. We aimed to determine if CYP2B6 composite metaboliser genotypes influence lipids, glucose and ALT concentrations. Methods: Data and DNA from South African antiretroviral therapy (ART)-naïve participants …
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Personalized medicine in rheumatoid arthritis: Pharmacogenetics of anti-TNF and beyond.
Contains fulltext : 129676.pdf (Publisher’s version ) (Open Access)
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Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients
Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which …
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Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
Background: Among individuals treated for HIV-1 infection, renal toxicity is more likely with tenofovir disoproxil fumarate (TDF) than with tenofovir alafenamide (TAF). Limited previous studies suggest potential genetic associations with TDF-associated renal toxicity. We hypothesized that …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… We characterise dolutegravir pharmacokinetics, pharmacogenetics, and its drug-drug interaction with the antituberculosis drugs rifampicin and rifabutin and with the antimalarial drugs artemether-lumefantrine and artesunate-amodiaquine. We also describe the pharmacokinetics of tenofovir when …
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Pharmacogenetics of African populations : variation in major drug metabolising enzyme genes and potential impact on personalised medicine.
Includes bibliographical references (leaves 167-200)
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Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children
Efavirenz and nevirapine are the most widely used agents for treatment of HIV in children. Sources of variability in their pharmacokinetics and its association with virological outcome and adverse events in African children are poorly characterised, thereby limiting treatment optimisation. To fill …
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Pharmacogenetics of stavundine : role of genetic variation in mitochondrial DNA and polymerase gamma among adult Malawian HIV/AIDS patients
Infectious diseases are endemic in Africa, especially tuberculosis (TB), malaria and human immunodefiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). Genomics research has the potential to improve the health of Africans through identification of genetic markers associated with either …
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Payer Perspectives On Preemptive Pharmacogenetic Testing
Purpose: As preemptive pharmacogenetics expands in the academic healthcare setting, further study is needed to assess the views of additional stakeholders in the marketplace on this technology and the barriers and facilitators to their uptake. The purpose of this study is to investigate the …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
Globally, it is estimated that over one billion individuals live with hypertension. The prevalence of resistant hypertension can be as high as 19% among African populations. Genetic variation in genes that affect the metabolism and transport of antihypertensive drugs has been reported to influence …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… determined variability is pain inhibition. The pharmacogenetics of morphine analgesia is fairly well characterized, but far less is known about other analgesics. In a systematic study of variable antinociceptive sensitivity to morphine and four non-mu-opioid analgesics in mice, we unexpectedly …
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Human Genetics, Psychotropic Drugs, and Acts of Violence
… blood.</p> <p>The guidelines set by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) do not apply in cases of polypharmacy or when there is more than one-drug-one gene interaction involved. An easy-to-use protocol is described that …
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Increasing Inclusion of Participants, Leveraging Gut Microbiomes, and Optimizing Machine Learning Models to Advance Warfarin Precision Medicine
… this thesis we briefly introduce the fields of pharmacogenetics, pharmacomicrobiomics, and statistical modeling to provide evidence for each of the previous suggestions demonstrated by the attached appendices. Finally, we make predictions regarding the future of warfarin precision medicine.
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… limited knowledge exists regarding the impact of pharmacogenetics on statin tolerance among South African patients. This study aimed to examine the relationships between genetic variants in the five pharmacogenes mentioned and SAMS in a cohort of dyslipidaemia patients from South Africa undergoing …
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Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… transporters, and drug metabolizing enzymes; and pharmacogenetics appeared as the science that studies the relationship between drug response and genetic variation.</p> <p>Thiazide diuretics are the recommended first-line monotherapy for hypertension (i.e. SBP>140 or DBP>90). Even so, diuretics …
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