Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Pharmacogenetic"”.
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Payer Perspectives On Preemptive Pharmacogenetic Testing
Purpose: As preemptive pharmacogenetics expands in the academic healthcare setting, further study is needed to assess the views of additional stakeholders in the marketplace on this technology and the barriers and facilitators to their uptake. The purpose of this study is to investigate the …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… three studies underscore the critical role of pharmacogenetics and pharmacokinetics in advancing precision psychiatry. By elucidating the genetic and pharmacokinetic factors influencing antidepressant treatment outcomes, the thesis provides a foundation for optimizing and personalizing …
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Facilitating Pharmacogenetic Association Studies Using an Extensible Genotype Information Management System
Large-scale genome data projects employing automated, high-throughput techniques have led to a deluge of genomic data that necessitate robust informatic solutions. COBRA-DB is an integrated web-based genome information management system that provides storage for pharmacogenomic information …
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Depression Outcomes in Care Coordination, Primary Care and Psychiatry Patients After Pharmacogenetic Testing
… outcomes of patient activation before and after pharmacogenetic care in a coordinated care population. The process of pharmacogenetic care includes the patient’s acknowledgment of medication changes which are based on their genetic profile. This study will be framed by Dorothea Orem’s Self-Care …
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Economic Evaluation of a Point of Care Pharmacogenetic Test (CYP2C19) from an Ontario Perspective
… to patients with a loss of function allele. Pharmacogenetic (PGx) testing could optimize pharmacotherapy (i.e. fewer adverse event rates with PGx option, where results are available in 1 hour) Purpose: To quantify net social benefit of implementing a PGx test in Ontario hospitals. Methods: A …
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Pharmacogenetic markers of response to drugs used in the management of Inflammatory Bowel Disease
… effects and non-response. We aimed to identify pharmacogenetic markers of response to commonly used immunosuppressive medication in these patients.<br/>Methods: The influence of MTHFR 677C>T, MTHFR 1298A>T, ATIC 347C>G, TSER *2/*3 tandem repeat, TYMS 3’-UTR 6 bp insertion/deletion, SLC19A1 …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
OBJECTIVE: We examined several analytic methods for predicting therapeutic response to drug in Korea asthmatics and tried to develop a clinical model to predict the drug response to asthma drug. BACKGROUND: Long acting β2-agonists (LABA) is the most powerful bronchodilator and inhaled …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
Background: Antiretroviral therapy (ART), notably lopinavir and nevirapine substantially reduces Human immune-deficiency virus (HIV) associated morbidity and mortality in HIVinfected children. Low concentrations of nevirapine and lopinavir have been linked to inferior virological outcomes; it is …
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Pharmacogenetics : ethics and public policy
… and drug response, it was only recently that pharmacogenetics has been introduced as a new paradigm for drug development and optimum use. Associating the various genetic variations from clinical phenotypes may not be so direct. Moreover, challenges for future pharmacogenomics and its …
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METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
Second-generation antipsychotics (SGAs) are increasingly used in pediatric patients both in and offlabel. The rise in SGA prescription rates may be due to the perception of improved safety compared with first-generation antipsychotics. However, SGA use is often associated with rapid weight gain and …
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Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
The term "pharmacogenetics" has been defined as the scientific study of inherited factors that affect the human drug response. Many pharmacogenetie studies have been published since 1995 and have focussed on the principal enzyme family involved in drug metabolism, the cytochrome P450 family, …
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Pharmacogenetic analysis of admc polymorphisms affecting the efficacy of TB treatment in tuberculosis patients from Tanzania and Uganda, and pharmalogical evaluation of potent medicinal plant extracts used in the treatment of tuberculosis
… Aim: This study was aimed at evaluating the pharmacogenetics of Tanzanian and Ugandan tuberculosis patients, and pharmacological effects of medicinal plants [S. brachypetala (MMV004), R. caffra (MMV003), S. molle (MMV005), Z. mucronata (MMV002) and S. petersiana (MMV001)], used for the …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… thesis investigated the impact of both common pharmacogenetic variants and PRSs on antidepressant response, side effects, and serum exposure using a well-characterized clinical trial from the Canadian Biomarker Integration Network in Depression (CAN-BIND-1) and conducting a meta-analysis. In …
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Human host and malaria parasite genome variations to susceptibility to malaria
… determine whether there are differences in the pharmacogenetic profiles when comparing populations residing in malaria endemic and non-endemic areas. Methodology: Genome-wide genotype datasets (n=13, 447) from four malaria endemic African populations, including Mali, Kenya, Gambia, and Malawi, …
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Genetic Determinants of Human Susceptibility to Infections: A Multi-faceted Exome-based Analysis in the UK Biobank
… of infection-related genetic variants, and pharmacogenetic interactions in COVID-19 outcomes. The first research chapter employed whole exome analysis to identify 30 genetic variants independently associated with immune responses to six common pathogens. Fine-mapping revealed 30 causal …
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… Strong evidence links SAMS susceptibility to pharmacogenetic variability of ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1, particularly in Asian and European populations. However, limited knowledge exists regarding the impact of pharmacogenetics on statin tolerance among South African patients. …
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Studies investigating the impact of select genotypes on the pharmacological effect of fenofibrate
… hypothesis by conducting Fenofibrate and the Pharmacogenetic Impact (FPI) study, a pharmacokinetic study aimed at explicitly quantifying the effect of UGT2B7 A-327G on fenofibric acid serum concentration. Furthermore, we discovered that UGT2B7 A-327G modulated the uricosuric effect of …
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Exploring Barriers to the Adoption of Pharmacogenomic Technology in the Clinical Setting by Clinical Healthcare Providers
… knowledge, attitudes and experience concerning pharmacogenetic technology in a spectrum of different healthcare providers and types, and was administered online. This study found both knowledge and attitude, overall, to be highly correlated to adoption likelihood. Lack of knowledge was the most …
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