Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Pharmacoepidemiology"”.
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Pharmacoepidemiology and Drug Safety: Examining Clinical Drug Trials Via Technology
… (IT) in the fields of clinical research and pharmacoepidemiology. The primary research project explores a means of identifying a cost effective, and robust mechanism for conducting large scale clinical study using IT. The thesis was devised after examining the findings of the Monitorización …
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A Nationwide Study of ADHD Drug Use among Adults in Iceland 2003-2012
… attention deficit/ hyperactivity disorder; ADHD; pharmacoepidemiology; drug utilization; treatment duration; central nervous system stimulants; adults
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Chemoprevention in Kidney Cancer
… in kidney cancer. Furthermore, risk estimates in pharmacoepidemiology may be sensitive to the method of classifying exposure.
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Determinants Of Drug Utilisation During Childhood
… of drug prescription in paediatrics. Pharmacoepidemiology and the use of administrative databases can be a useful tool for this scope. Data collected in regional and multiregional administrative prescription databases were analysed. Prevalence data by sex and age were calculated by …
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Optimization of Signal-Detection Methods in Novel Databases: a Focus on Direct-Acting Antivirals
… there is interest in pharmacovigilance and pharmacoepidemiology in using real-world data as a complementary data stream to spontaneous report databases. The current study used medical and pharmacy claims from the Merative MarketScan Commercial Databases to evaluate and validate the possible …
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Causal Inference with Survival Outcomes via Orthogonal Statistical Learning
… safety concerns–both being critical aspects for pharmacoepidemiology research. This systematic approach leverages the convergence of expanding healthcare data sources and modern data science advances to establish a data-driven framework for drug repurposing discovery and pharmacovigilance. To …
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Quantifying the Risk of Beta-Blockers and Non-Steroidal Anti-Inflammatory Drugs in Asthma
Beta-blockers and non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided in asthma over risk of bronchospasm which may vary according to drug selectivity and duration of administration. This thesis attempts to quantify the risk of beta-blocker and NSAID exposure in asthma by synthesising …
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
Polypharmacy leads to increased risk of drug-drug interactions (DDI’s). In this dissertation, we create a database for quantifying fraction of metabolism (fm) of CYP450 isozymes for FDA approved drugs. A reproducible data collection protocol was developed to extract key information from publicly …
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Commonly used medications and survival from ovarian cancer
Background: Ovarian cancer is the 5th leading cause of cancer-related death among women in the United States. Typically diagnosed as a late stage disease, it follows an aggressive clinical course resulting in 5-year survival proportions of less than 50% for all stages and less than 30% for advanced …
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Separability of Effects in the Analysis of Complex Observational Data
Observational studies contribute to the overall body of knowledge, frequently capturing how medicine is practiced in a real-life setting, where patients and therapies are diverse and not limited by research protocol. However, they can present analytic challenges for these reasons, among them …
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The Use of Oncology Electronic Health Record Databases to Assess the Effectiveness of Breast Cancer Treatment
… patterns and treatment adherence. Historically, pharmacoepidemiology research in the oncology setting has been limited, mainly due to poor capture of important confounding factors in real-world data sources (e.g., tumor grade, histology, and location, laboratory values, biomarkers, and …
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Influenza Antivirals in Adults: Analyzing Usage Trends, GI Safety, and Cardiovascular Risk Reduction
This dissertation explores how influenza antiviral therapy is used in everyday clinical practice among U.S. adults, with a focus on its safety profile and potential cardiovascular benefits. Seasonal influenza remains a major public health concern, contributing to substantial morbidity, mortality, …
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Multi-drug association rule mining on graphics processing unit
"Medicine is an essential part of many people's health and wellbeing . However, drugs sometimes cause symptoms, many of which have yet to be associated to a drug or combination of drugs. Mining patient data allows unknown associations between drugs and symptoms to be discovered. General-purpose GPU …