Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Pharmacodynamics"”.
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Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites
… drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). The reversible metabolism of pentoxifylline to the enantiomers of M1 …
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Antimicrobial pharmacodynamics: The gentamicin - Escherichia coli relationship
The purpose of this thesis was to: (1) explore the in vitro dose-response relationship between gentamicin and Escherichia coli under conditions of constant and declining antibiotic concentrations and (2) to characterize the kinetics of the relationship in an attempt to better predict antimicrobial …
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Pharmacokinetics and Pharmacodynamics of Theophylline in Ruminating Calves
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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Pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds
… were to investigate the pharmacokinetics and pharmacodynamics of non-steroidal anti-inflammatory drugs in birds. For decades, the inflammatory process and the properties of the NSAIDs have been extensively investigated in humans and other species. However, current knowledge on inflammation and …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… understanding of local pharmacokinetics (PK) and pharmacodynamics (PD) in the myocardial tissue. Our central hypothesis is that early success at inducing vessel growth powerfully self-regulates angiogenic therapies by dynamically altering local tissue pharmacokinetic properties and hinders …
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Overview of the Genetic Background Influencing the Pharmacokinetics and Pharmacodynamics of Statins
… aims to review the genetic factors affecting the pharmacodynamics and pharmacokinetics of statins.
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Analysis, pharmacokinetics, metabolism and pharmacodynamics of labetalol in pregnant and nonpregnant sheep
… in the literature about the disposition or pharmacodynamics of labetalol in the in utero fetus. Hence, a detailed investigation into the maternal-fetal pharmacokinetics and pharmacodynamics of labetalol was undertaken. Studies in adult nonpregnant sheep were also conducted to complement the …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in TB/HIV coinfected patients recruited in two phase III clinical trials (61 patients in TB-HAART and 222 patients in RAFA study) were described using nonlinear mixed-effects modelling. Concentration-time data for rifampicin …
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Investigation of Carbamathione Pharmacokinetics and Pharmacodynamics by In Vivo Microdialysis and Capillary Electrophoresis
… in order to elucidate the pharmacokinetics and pharmacodynamics of carbamathione. The effect of disulfiram on the brain neurotransmitters was evaluated. The significance of this research is that carbamathione may be involved in the anti-craving effect observed with disulfiram, and thus may be …
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Evaluation of the pharmacokinetics, pharmacodynamics, and safety of enrofloxacin administration to pregnant mares
… effects on the fetus, the pharmacokinetics and pharmacodynamics of the enrofloxacin in both the intravenous form and a newer oral form were evaluated in the pregnant mare. After determining the optimal dose, and a higher dose that might be used to treat intermediately susceptible bacteria, mares …
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Pharmacokinetics and pharmacodynamics of some NSAIDs in horses: A pharmacological, biochemical and forensic study
Non-steroidal anti- inflammatory drugs (NSAIDs) have been in use for over 100 years to treat pain, exerting their analgesic effect by inhibiting prostaglandin (PG) synthesis via the COX pathway. Some of the NSAIDs have adverse side effects including ulceration of the stomach and cardiovascular …
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Dexmedetomidine : a phase I study to evaluate the pharmacokinetics and pharmacodynamics in paediatric patients
Includes bibliographical references.
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of nitrofuranylamide lead compounds suitable for further development. </p> <p> First, we examined the biopharmaceutic properties and preclinical PK of nitrofuranylamide lead …
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The pharmacokinetics and pharmacodynamics of oral ponazuril in the treatment of systemic isosporosis in passerine birds
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Optimizing pharmacodynamics and evaluating echocardiographic effects of alfaxalone sedation in bearded dragons (Pogona vitticeps) and prairie rattlesnakes (Crotalus viridis)
Alfaxalone, a neurogenic steroid with action at the γ-aminobutyric acid A receptor, is an injectable sedative frequently utilized in squamate medicine. A novel formulation of alfaxalone was recently approved by the Food and Drug Administration for 28-day use after breaching the vial due to the …
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