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Showing 1 to 20 of 137 for “"Pharmaceutics and Drug Design"”.
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Hybrid Cyclic/Linear Peptides in a Multi-Component Lipid Structure as a siRNA Delivery System
… rapid elimination via glomerular filtration, and inability to cross cell membranes due to the hydrophilic and negatively-charged nature. Thus, a delivery system is needed to deliver the siRNA into the cells by crossing the negatively-charged phospholipid cell membrane. The goal of this project …
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Dissolution testing of prednisone and salicylic acid calibrator tablets at different tablet locations
… both non-disintegrating tablets (salicylic acid) and disintegrating tablets (Prednisone) were experimentally determined for many different tablet locations, both centered on the vessel bottom and off-center. The location of the tablet was experimentally varied in very small increments in order to …
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Dissolution of disintegrating solid dosage forms in a modified dissolution testing apparatus 2
… Dissolution testing serves as a surrogate for drug bioavailability through in vitro-in vivo correlation (IVIVR), and it additionally helps in guiding the development of new formulations and in assessing lot-to-lot consistency, thus ensuring product quality. The United States Pharmacopoeia (USP) …
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Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
… study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage …
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Comparative analysis of the dissolution performance of aspirin tablets in the usp apparatus 2 and in a minivessel dissolution system
… to aid in the behavior of formulations, and to optimize drug release from dosage forms. The use of compendial dissolution test apparatus and techniques, such as the USP 2 (Paddle), to characterize the dissolution performance of oral drug delivery system is an established area of …
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Experimental investigation of the fluid velocity distribution in stirred tank reactors equipped with retreat-blade impellers using laser doppler velocimetry
… of Active Pharmaceutical Ingredients (API's) and their intermediates. Typically, these vessels are glass-lined and are provided with a single retreat-blade glass-lined impeller and a single baffle. Despite their ubiquitous utilization in the pharmaceutical industry for at least the past 40 …
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Experimental determination of the mixing requirements for solid suspension in pharmaceutical stirred tank reactors
Glass and glass-lined, stirred-tank reactors are of significant importance in the pharmaceutical and related industries. Because of fabrication issues, a retreat blade impeller (RBI) with a low impeller clearance off the tank bottom is commonly used in glass-lined reactors, typically combined with …
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Minimum agitation speed for solid suspension and mixing time in a torispherical -bottomed pharmaceutical stirred tank under different baffling conditions
… mixing tank provided with a torispherical bottom and agitated with a retreat-blade impeller under different baffling configurations. Ns for the same tank but equipped with a different agitation system, namely an axial impeller, was also experimentally determined for the purpose of comparing of …
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Computational and experimental determination of the hydrodynamics in a stirred unbaffled vessel provided with angle-mounted axial impellers
In most industrial applications, stirred tanks and reactors are typically provided with baffles to improve their mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it …
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Engineering spores to display g protein-coupled receptors for directed evolution
… involved in almost every physiological process, and irregular control leads to pathological conditions. Therefore, they are major drug targets. Crystal structure determination is required to understand the molecular details of activation/deactivation. However, GPCRs are difficult to crystallize …
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Modeling and Prediction of Amorphous Solid Dispersion Formation Using a Molecular Descriptor
… ingredient (API) is a significant hurdle during drug development. Delivering a drug in its amorphous solid-state is a potential method to overcome this issue, since the amorphous form has increased apparent aqueous solubility. However, the amorphous state is only metastable, and is …
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Preparation of nanovehicles for targeted drug delivery
… research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective and enhanced absorption. This work …
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
… breast cancer subtype with poor prognosis and is difficult to treat. A diagnosis of TNBC means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone, and HER2– are not present in the cancer tumors. Since the tumor cells lack necessary …
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Design, Synthesis, and Evaluation of a Novel Cytotoxic Peptide-Doxorubicin Conjugate Targeting Triple-Negative Breast Cancer
<p>The aim of this thesis was to design, synthesize, and characterize a novel peptide-doxorubicin conjugate, evaluate in vitro stability and cytotoxicity properties of the conjugate and study its mechanism for uptake into the triple-negative breast cancer (TNBC) cells. For the synthesis of the …
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Mixing performance of a novel, continuous confined impinging jets mixer using competitive reactions
… effectiveness improvements in different physical and chemical processes. In the competitive reactions system used here (third Bourne reaction), one stream containing sodium hydroxide was continuously fed to the first impinging jet, while an aqueous solution of hydrochloric acid and ethyl …
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Effect of impeller submergence on power dissipation and solids suspension in mixing systems equipped with pitch-blade turbines
Mixing and dispersion of solids in a liquid is a process frequently encountered in the pharmaceutical industry and often conducted in cylindrical baffled tanks stirred by mechanical impellers. In operations where the liquid level is decreased (as often which emptying the tank) the process must be …
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Experimental determination of solids suspension with angled impeller in a pharmaceutical mixing vessel
… In these systems, the impeller is not centrally and vertically mounted, as in most stirred vessels, but it enters the vessel, and is therefore immersed in the fluid, at an angle from the vertical. This arrangement provides some baffling effects that would not otherwise exist if the impeller was …
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Effect of tablet compression on the dissolution of aspirin tablets using a novel off-center paddle impeller (opi) dissolution testing system
… has been shown to produce test failures and to be very sensitive to a number of small geometry changes. The objective of this study was to determine whether a novel dissolution system termed "OPI" for "off-center paddle impeller" was sensitive enough to determine differences in tablet …
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Novel experimental method for the determination of the minimum agitation speed for solids suspension in flat-bottomed stirred tank reactors
… of visually inspecting the tank bottom and visually determining the impeller agitation speed at which the solids are observed to rest on the tank bottom for no more than 1-2 seconds before being swept away. This method is quite reliable, but a method not relying on the operator would …
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Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines.
… cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than traditional platinum-based …
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