Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 2833 for “"Pharmaceutical."”.
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Essays in pharmaceutical economics
This thesis consists of three empirical essays in pharmaceutical economics, which explore the role regulation plays in influencing firm behavior. In the first chapter I examine competition in the neglected disease submarket of the biopharmaceutical industry. Using a combination of novel panel data …
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Electrospinning for pharmaceutical applications
The pharmaceutical industry is currently shifting from batch to continuous manufacturing, and for downstream processes, this shift can reduce costs and improve quality provided the new unit operations are chosen properly. Electrospinning, a method of making nanofiber mats from solutions of an …
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Pharmaceutical policies used in LMIC countries to enhance pharmaceutical spending efficiency: a review
Pharmaceutical spending makes up for a major share of healthcare costs in Low- and-MiddleIncome Countries (LMICs), where access to essential medicines is hindered by high prices, inefficient procurement, and restricted budget. In order to achieve Universal Health Coverage (UHC), there must be …
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Heterogeneous nucleation of active pharmaceutical ingredients on polymers : applications in continuous pharmaceutical manufacturing
In this thesis work, we aimed to explore crystallization processes for small molecule API compounds based on engineered polymer surfaces that could be used in continuous manufacturing. First, we identified a library of polymers that can be used and selected PVA as the model polymer based on its …
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Modeling picking on pharmaceutical tablets
… are the most popular solid dosage form in the pharmaceutical industry because they are cheap to manufacture, chemically and mechanically stable and easy to transport and fairly easy to control dosage. Pharmaceutical tableting operations have been around for decades however the process is still …
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Polymeric nanocapsules for pharmaceutical applications
Polymeric nanoparticles can be used for drug release in cancer therapy. Nanoparticles can be divided into nanospheres and nanocapsules, accordingly to their structure. Nanospheres are constituted by just the polymer, while nanocapsules have an inner liquid core surrounded by a polymer layer. Drug …
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Insurance Design and Pharmaceutical Innovation
… studies how insurance coverage policies impact pharmaceutical innovation. In the United States, most patients obtain prescription drugs through insurance plans administered by Pharmacy Benefit Managers (PBMs). Beginning in 2012, PBMs began refusing to provide coverage for many newly approved …
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Stability of solid pharmaceutical proteins
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1995.
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Modeling reduction of pandemic influenza using pharmaceutical and non pharmaceutical interventions in a heterogeneous population
… more recent 2009-2010 H1N1 "Swine Flu" scare, pharmaceutical as well as non-pharmaceutical resources are limited in availability and effectiveness. In this thesis we apply OR methods to evaluate the effectiveness of such resources and the strategies for reducing the number of infections …
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FORENSIC PHARMACEUTICAL ANALYSIS OF COUNTERFEIT MEDICINES
… world. Reference spectra of appropriate active pharmaceutical ingredients (APIs) and excipients were created, for each method, as part of the identification process. Currently only Raman and ATR-FTIR delivered quantitative results which were based on automated multivariate analysis. For tablets …
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… the expression and exploitation of IF/cubilin in pharmaceutical development.</p> <p>Q1: (Chapter 2) Does an 89Zr-B12 conjugate allow for improved background/noise ratio, relative to 99mTc and 64Cu B12 conjugates, in in vivo tumor uptake? </p> <p>Goal: Conduct positron emission tomography (PET) …
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Nucleation and growth of pharmaceutical crystals
Investigating nucleation, crystal growth and solid-state transformations at the nanoscale are of significant interest, as more complex routes have roused questions about the classical view of these processes. This thesis reports the characterisation of prenucleation clusters in olanzapine (OZPN) …
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Novel Resorcinol Platforms with Pharmaceutical Applications
The rationale behind this work is the discovery that a number of natural bromophenols from algae have antibiotic and antioxidant activities. Most natural compounds are based on phenol and catechol. Previous studies by the group investigated a novel class of halogenated compounds based on resorcinol …
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Cavitation in Pharmaceutical Manufacturing and Shipping
… (1) assess the risk of cavitation under common pharmaceutical manufacturing conditions (i.e., pipe contraction and pumps), (2) establish a simple threshold criterion, and (3) suggest a series of mitigation techniques based on these thresholds. To accomplish these tasks, computational fluid …
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Spore-forming bacteria as pharmaceutical factories
… shows that it might be feasible to use spores as pharmaceutical formulations. A number of challenges remain: from fabrication, through limits of current good manufacturing practice, to engineering biology to protect the environment and commercial interests. Bacterial spores have for the past …
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Outsourcing research in the pharmaceutical industry
Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1995.
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Redefining how pharmaceutical innovation gets done
… of research and development in the bio-pharmaceutical industry has been constantly declining since the early 2000's. One possible reason is that biomedical projects are risky, take a long time, and require significant investment. Hence, substantial capital has been shifted away from the …
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Continuous blending of dry pharmaceutical powders
Conventional batch blending of pharmaceutical powders coupled with long quality analysis times increases the production cycle time leading to strained cash flows. Also, scale-up issues faced in process development causes delays in transforming a drug in research to a drug under commercial …
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