Global ETD Search
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Showing 1 to 17 of 17 for “"Pharmaceutical tablets"”.
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Modeling picking on pharmaceutical tablets
<p>Tablets are the most popular solid dosage form in the pharmaceutical industry because they are cheap to manufacture, chemically and mechanically stable and easy to transport and fairly easy to control dosage. Pharmaceutical tableting operations have been around for decades however the process is …
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Geometric modelling and shape optimisation of pharmaceutical tablets. Geometric modelling and shape optimisation of pharmaceutical tablets using partial differential equations.
Pharmaceutical tablets have been the most dominant form for drug delivery and they need to be strong enough to withstand external stresses due to packaging and loading conditions before use. The strength of the produced tablets, which is characterised by their compressibility and compactibility, is …
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Investigating the Hydration and Disintegration Mechanisms of Film-Coated Pharmaceutical Tablets
The pharmaceutical tablet is the most common solid oral dosage form to administer drug or active pharmaceutical ingredient (API) to patients. Tablets are often film-coated with a layer of polymeric material to protect the drug from environmental degradation, facilitate the packaging process, and …
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Activation of Release by Hydration in Pharmaceutical Tablets Studied by Terahertz Pulsed Imaging
Tablets are one of the most common pharmaceutical dosage forms. The liquid ingress into a tablet is considered to be the first, and often rate-determining, step for tablet disintegration and subsequent drug dissolution. Even for tablets that do not disintegrate (e.g. sustained release tablets), …
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Design of hot extrusion molding device for the continuous production of pharmaceutical tablets
Currently, pharmaceutical tablets are manufactured in large batch operations that have inefficiencies associated with the stopping, re-configuration and testing between batches. Continuous manufacturing has the potential to lower manufacturing costs and energy consumption while enhancing process …
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Improving the Strength of Binder Jetted Pharmaceutical Tablets Through Tailored Polymeric Binders and Powders
… an attractive means for producing individualized pharmaceutical tablets. However, due to the low density of the printed specimens and incompatible binder-powder combination, tablets fabricated by this AM technology suffer from poor strength. The research is introducing an additional composition in …
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The effect of die geometry on extruded paste flow for continuous production of pharmaceutical tablets
… tablet forming process of a sample active pharmaceutical ingredient (API) and ethyl acetate requires a device to form and compress the tablets. The flow of the wet extrusion is driven by the pressure head generated by the torque of the screws; the minimum pressure head is dictated by the …
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The chemical and physical characterisation of illicit tablets and development of a statistical model to identify populations within the illegal supply chain
Diazepam is an effective pharmaceutical used for both medicinal and illicit purposes and its popularity has led to the sale of both diverted pharmaceutical tablets and illicitly manufactured products. The aim of this project was to characterise 65 different cases of illicit tablets seized from the …
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Terahertz Methods for Investigating the Liquid Transport Characteristics in Porous Media
… processes, such as the disintegration of pharmaceutical tablets as well as the impregnation of catalyst supports and heterogenous catalysis. In this thesis, the terahertz methods, i.e. terahertz time-domain spectroscopy (THz-TDS) and terahertz pulsed imaging (TPI), were used as promising …
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Direct tablet formation by electrospinning and compaction
… physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. …
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The development of a thin-film rollforming process for pharmaceutical continuous manufacturing
… as a key step in the continuous manufacturing of pharmaceutical tablets. HPMC and PEG based polymeric thin-films were considered for this application. An experimental apparatus was designed and developed to test the folding of thin-films. The experimental apparatus was designed in a modular …
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Pharmaceutical tablet compaction : product and process design
… strategy for formulation and process design of pharmaceutical tablets is proposed. A modified nanoindenter method was used to test the mechanical behavior of diametrally compressed excipient granules. X ray micro computed tomography and Terahertz pulsed spectroscopy (TPS) and imaging (TPI) were …
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Novel Strategies using Micro Pressurized Liquid Extraction to Rapidly Prepare Solid Samples for Analysis
… applied to a variety of solid samples including pharmaceutical tablets, green tea leaves, and samples containing polycyclic aromatic hydrocarbons. This micro preparative approach will be shown to provide rapid, quantitative extractions when compared to conventional methods. Frequently, total …
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On the Compaction of Granular Matter; Continuum and Discrete Numerical Modelling
… apparent when creating powder formulations for pharmaceutical tablets, where the combination of various powders makes mechanical properties difficult to predict. In the pharmaceutical industry, this is known as the formulation problem and creates many difficulties when trying to compact a powder …
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The development and application of online modelling methods
… technology, the NIR spectral analysis of pharmaceutical tablets. The NIR spectra of over 250 tablets were collected over three production campaigns from 1997 to 1999. Accompanying the NIR spectral data were the chemical and physical tablet parameters, active pharmaceutical ingredient, …
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Designing A Calibration Set in Spectral Space for Efficient Development of An NIR Method For Tablet Analysis
… calibration method for quantitative analysis of pharmaceutical tablets. This step is critical because successful model development depends on the suitability of the calibration data. For spectroscopic-based methods, traditional concentration based techniques for designing calibration sets are …
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Condition monitoring of pharmaceutical powder compression during tabletting using acoustic emission
… system for the final production quality of pharmaceutical tablets and detection capping and lamination during powder compression process using the acoustic emission (AE) method. Pharmaceutical tablet manufacturers obliged by regulatory bodies to test the tablet's physical properties such as …