Global ETD Search
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Showing 1 to 6 of 6 for “"Pharmaceutical solids"”.
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… technology for particle engineering of active pharmaceutical ingredients and excipients was developed. The present novel technology MASCW process is described as green technology as water is used as the solvent medium and microwave energy as external source of heat energy for generation of a …
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Methods for Increasing Sensitivity and Throughput of Solid-State NMR Spectroscopy of Pharmaceutical Solids
… and dynamics of a pure or formulated active pharmaceutical ingredient (API). To overcome the major shortcomings of SSNMR, acquisition time and sensitivity, a two-sample probe was designed, developed, and tested. The probe allowed for two samples to be acquired simultaneously while being …
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Structural studies of organic crystals of pharmaceutical relevance. Correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state
Pharmaceutical solids tend to exist in different physical forms termed as polymorphs. Issues about pharmaceutical systems are mainly concerned with the active ingredient's physico-chemical stability and bioavailability. The main aim of this study is to investigate the non-bonded interactions in …
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EXPERIMENTAL AND COMPUTATIONAL ANALYSIS OF RELATIVE ENERGETIC STABILITIES OF CRYSTALLINE ANHYDROUS POLYMORPHS AND PSEUDOPOLYMORPHS
<p>The stability of pharmaceutical solids is impacted by the properties of both active and inactive ingredients. Given that the aqueous solubility of solid-state medicinal products can be directly linked to the component properties, it is prudent to carefully study these materials to predict …
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The role of moisture profiling towards understanding pharmaceutical solid state functionality. Validation and the application of a moisture profiling analytical tool for investigation into the characterisation of and prediction of the effects of compaction and storage on different lactose physical forms
The majority of therapeutic pharmaceutical formulations are presented in the solid form. Moisture is able to play an important role in the functional performance of pharmaceutical solids. Moisture profiling is able to provide novel information with regards to the behaviour of moisture within …
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An investigation into the synthesis, structural characterisation, thermal and polymorphic behaviour of organic crystalline materials
… materials have a big impact upon society, e.g. pharmaceuticals. Traditionally, the process of selecting active pharmaceutical ingredients (APIs) was limited to free drug or accepted salt formulations. The cocrystallisation of APIs with a former molecule significantly increases the developmental …