Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Pharmaceutical production"”.
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Implementation of the new FDA quality by design guidance in pharmaceutical production
… it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. This resource intensive process discourages continuous improvement and often results in outdated and …
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Financing ARV Drug Manufacture in Zimbabwe: Implications for technological capability upgrading and innovation for African local pharmaceutical production
… and professional discourses on local African pharmaceutical manufacture have concentrated on technology, technology transfer, economies of scale, human capital, and markets for drugs; neglecting the financing of working capital and capital investment and the role played by banks. When finance …
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Direct tablet formation by electrospinning and compaction
… physical system were developed to manufacture pharmaceutical tablets through an electrospinning operation and subsequent compaction. Theoretical simulations of the electrospinning were run to predict physical system performance, and a proof-of-concept device was designed, produced and tested. …
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New Strategies for the Qualitative and Quantitative Analysis of Nitrofural and Its New Derivatives // Нови стратегии за качествения и количествен анализ на Nitrofural и неговите нови производни
… has become increasingly important in global pharmaceutical production. Today, in pharmaceutical practice, the concept of polymorphism is the knowledge that polymorphism is the most crucial factor determining the biological effect and ultimate therapeutic efficacy of many drugs. The …
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Pharmaceuticals in industrial wastewater and their removal using photo-Fenton’s oxidation
Active pharmaceutical ingredients are known contaminants of surface and ground water. In some cases these are persistent organic chemicals which are only partially eliminated during conventional wastewater treatment. They have been detected in the effluent of various European wastewater treatment …
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Screening for novel cold-adapted nitrile hydratases in Antarctic metagenornic libraries
… interest for its potential use in chemical and pharmaceutical production. Enzymes isolated from psychrophilic bacteria typically have a high specific activ ity and low thermal stabi lity to cope with the inhibition of chemical reactions caused by low temperatures. However, culture based …
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Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology
… makes this study an important benchmark for the pharmaceutical production industry.
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The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
… syntheses, that are directly applicable to pharmaceutical production of these potentially valuable therapeutic compounds. Several new products unique to barbituric acid reactions were characterized spectroscopically. Barbituric acid derivatives were the subject of biological evaluation, and …
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An ergonomic job analysis of a work process within a glovebox
… associated with the use of a glovebox in a pharmaceutical production facility. Using direct observation and detailed job analysis, design shortcomings were identified. Four ergonomic assessment tools were used to evaluate the combinatorial effect of the upper limb extremity postures, applied …
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Selection of castor with divergent concentrations of ricin and RCA using radial immunodiffusion
One of the most limiting factors in the production of castor (Ricinus communis L.) is the presence of two toxic proteins, ricin and RCA. Ricin and RCA's presence in the endosperm of the seed creates potential health hazards to both producers and processors. The objectives of this research were to …
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Design and Manufacture of a Modular Continuous Unit Dose Pharmaceutical Lyophilizer
Pharmaceutical lyophilization (freeze-drying) enables long term storage and simplified transportation for aqueous vaccines and protein formulations. Modern industrial pharmaceutical freeze-driers rely on large batch and open loop formulation processing, limiting supply chains and resulting in …
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A thermal-fluid analysis of piping dead-legs in high purity water systems
Purified water forms an integral part of pharmaceutical production. The consistency of water quality produced by purrficatron processes and distributed to points-of-use is of utmost importance Tee-sectlons Installed in distribution loops are commonly used to divert fluid flow at take-off points. …
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Novel continuous crystallization configurations for improved yield, purity and controlled crystal size distribution
… such as lower cost and improved flexibility in pharmaceutical production when compared to batch crystallization. A good continuous crystallization process should achieve a high product yield and purity comparable to current batch crystallization processes. The aim of this thesis is to develop …
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Is the pharmaceutical industry ready for value based procurement?
… in huge healthcare markets such as the pharmaceutical industry. To sustain shareholder value, as a result of these changing price structures, Novartis sees a need to reassess its sourcing and procurement strategies, assessing the feasibility of value based procurement, through staged …
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The complexity of antibiotic resistance dynamics in scarce surface water resources in northern Botswana
… associated with intensive agricultural systems, pharmaceutical production, wastewater, and health facilities. However, little research has been conducted on AR gene (ARG) dynamics in natural environments lacking large-scale human inputs. In particular, we have a limited understanding of the …
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Control of polymorphism in continuous crystallization
… in recent years as the ultra-lean mode of pharmaceutical production. Albeit the increasing number of studies on the process dynamics in continuous crystallization, in particular in yield improvement and impurity separation, the research community lacks the systematic understanding of the …
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Computational and experimental determination of the hydrodynamics in a stirred unbaffled vessel provided with angle-mounted axial impellers
… mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it reduces the potential for contamination and makes cleaning the vessel between batches easier. However, the lack of …
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Development of Micro to Milli-Scale Multiphase Reactors with and Without Solids for Integration Into Mini-Monoplants
… chemical processing differ between the bulk and pharmaceutical industries. Bulk chemicals are produced in large-scale, dedicated, continuous processes that are known to be more economical when flexibility in the equipment, reactions, and capacity is not required. In the pharmaceutical industry, …
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Optimisation of CHO Cell Line Development Using Hybrid Modelling for Antibody Therapeutics
Scaling up pharmaceutical production processes is an intricate and resource-intensive task, often starting inefficiently at the smallest scale. This approach is costly, time-consuming, and unsustainable, particularly for personalised medicines and biotherapeutics, which hold the potential to be the …