Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Pharmaceutical process"”.
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Near-Infrared (NIR) Spectroscopy-based Pharmaceutical Process Analytical Technology (PAT) Systems: Risk and Performance
<p>Process Analytical Technology (PAT) systems are used in the pharmaceutical industry to enhance the understanding and control the manufacturing processes. They are defined as systems for designing, analyzing, and controlling manufacturing operations through timely measurements of critical quality …
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Implementation of the new FDA quality by design guidance in pharmaceutical production
… it is difficult to implement changes to a pharmaceutical process. Even small change request approvals can require months of effort for pharmaceutical companies and regulatory agencies. This resource intensive process discourages continuous improvement and often results in outdated and …
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Application of machine learning methods for design of crystallisation processes
… the implementation of machine learning to aid in pharmaceutical process development. Machine learning (ML) algorithms can be applied to increase the speed with which high-value drug products are developed for the market while reducing the utilisation of material, minimising wastage and assuring …
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Modeling and experimental validation of a single-feed semi-batch precipitation process
… unit operation throughout the chemical and pharmaceutical process industries. Despite its widespread application, crystallization still suffers a disproportionate number of process difficulties due to the complexity of the steps involved in the process. In particular, the final …
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Characterisation of Tablets and Roller-Compacted Ribbons with Terahertz Time-Domain Pulsed Imaging
The pharmaceutical process of dry granulation using roller-compaction (DG/RC) is effectively a non-batch based procedure orientated to deliver a continuous stream of material free of a pre-defined batch-size with reduced plant equipment/scale-up R&D resources and an enhanced work-throughput, …
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Development of Micro to Milli-Scale Multiphase Reactors with and Without Solids for Integration Into Mini-Monoplants
Typical modes of chemical processing differ between the bulk and pharmaceutical industries. Bulk chemicals are produced in large-scale, dedicated, continuous processes that are known to be more economical when flexibility in the equipment, reactions, and capacity is not required. In the …
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Dissolvable microneedle manufacturing methods and the application of three-dimensional printing to pharmaceuticals
… dissolvable microneedles is micromoulding, a process which can have drawbacks of low material efficiency and high regulatory requirements. The UCC-patented “ImmuPatch” process is a micromoulding method which significantly improves on the material efficiency of traditional micromoulding. In …
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Near-Infrared Analysis and Process Control of Pharmaceutical Pelletization Processes
… spectroscopy in the determination of pharmaceutical pellet characteristics and to predict desired process endpoints during fluidized bed drug suspension layering and coating operations. Various strengths of diltiazem HCl pellets were prepared via a tangential-spray rotogranulation …