Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Pharmaceutical materials"”.
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Melt extrusion and continuous manufacturing of pharmaceutical materials
… helping to reduce time and costs associated with pharmaceutical solid dosage form production. The residence time distribution for melt extrusion has been characterized using a single parameter model. When combined with assumed first-order reaction rate kinetics and an Arrhenius reaction rate …
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Influence of impurities on the crystallisation of pharmaceutical materials
… from solution plays a significant role in the pharmaceutical, chemical and food industry, because it is widely used as a separation and purification technique. Nucleation is the first step of crystallisation, where the extremely small species called nuclei are formed in solution. This step …
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Characterization of Pharmaceutical Materials by Thermal and Analytical Methods
… States Pharmacopeia (USP) standard set of active pharmaceutical ingredients (API). DEA measures and differentiates the crystalline solid (low; 10¿¿¿¿¿ pS/cm) and amorphous liquid (high; 10¿¿¿ pS/cm) API electrical ionic conductivity. DEA ionic conductivity cycle establishes the quantitative …
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Multi-Component Characterization of Strain Rate Sensitivity in Pharmaceutical Materials
… is commonly accepted that plastically deforming materials tend to be more strain rate sensitive than brittle materials, but this sensitivity depends on how fast the material can respond to applied stresses. In addition, since many pharmaceutical materials also demonstrate relatively large amounts …
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Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties
… chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose …
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Coupling qualitative and quantitative analyses of pharmaceutical materials enabled by second harmonic generation microscopy
… From the initial establishment of an active pharmaceutical ingredient’s (API) crystal structure to stability testing and quality control, the phase of an API affects the solubility, bioavailability, stability, and efficacy of a drug product. Second harmonic generation (SHG) microscopy has …
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Applying Mechanistic Understanding of Optical Absorption and Scattering Phenomena to Enhance the Spectroscopic Analyses of Pharmaceutical Materials
… behaviors when NIR light interacts with pharmaceutical materials. The separated absorption and scattering were utilized to enhance mechanistic understanding of NIR diffuse reflectance spectroscopy and improve practical spectroscopic analysis in pharmaceutical applications.</p><p> …
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Multi-scale analysis and simulation of powder blending in pharmaceutical manufacturing
… out for gaining fundamental understanding of the pharmaceutical powder blending process. Through experiment, analysis and computer simulations, microscopic particle properties were successfully linked to their macroscopic process performance. This work established this micro-to-macro approach as a …
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Phase behaviour and crystal nucleation in complex multicomponent system
… for separation, purification and modification of pharmaceutical materials in multiple industrial sectors can be attributed to the potential for high control of product quality attributes. Nucleation is a key phenomenon in crystallisation that can control product purity, morphology and crystal size …
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Visible-light-mediated synthetic strategies for the synthesis of α-tertiary amine derivatives
… C–C bonds—is a motif that is widely prevalent in pharmaceutical materials and natural products. As a result of the fully substituted α-centre, compounds bearing this fragment have a high degree of structural complexity. This increased topological complexity has the result that α-tertiary amines …
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Crystallization process development and spherical agglomerates for pharmaceutical processing applications
… steps is essential in the production of many materials in the pharmaceutical, materials, and chemical industries. Additionally, due to increasing costs of research and development, reductions in manufacturing costs by moving from batch to continuous manufacturing are necessary to sustain …
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Development of a Pharmaceutical Tablet Authentication system using Spectroscopic Techniques in combination with Multivariate Chemometric Methods
… combat this horrendous activity, surveillance of pharmaceutical materials is required in the supply chain system. Spectroscopic techniques (e.g., Near-Infrared and Raman spectroscopies) can be a potential solution to authenticate samples in different locations; they are non-destructive, safe, …
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Development of a micro-feeder for cohesive pharmaceutical powders
In recent years, the pharmaceutical industry has been striving to improve drug manufacturing processes to enable the accurate production of small batches for precision medicine and small-scale clinical trial medicine manufacturing. This aims to reduce manufacturing costs, improve drug manufacturing …
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The rational design of drug crystals to facilitate particle size reduction. Investigation of crystallisation conditions and crystal properties to enable optimised particle processing and comminution.
Micronisation of active pharmaceutical ingredients (APIs) to achieve desirable quality attributes for formulation preparation and drug delivery remains a major challenge in the pharmaceutical sciences. It is therefore important that the relationships between crystal structure, the mechanical …
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Effect of dry particle coating on the properties of cohesive pharmaceutical powders
… of industrial applications, in this case the pharmaceutical industry. This work investigates the effect of dry particle coating to improve the flowability of cohesive active pharmaceutical ingredient (API) powders and their blends. Improving the flow properties of cohesive API powders can …
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Structural relaxations and crystallization in amorphous food model formulations
… and controlled structure deterioration require materials science characterization of components and mixtures. However, understanding phase transitions associated with structural relaxations and their coupling with properties of food materials is still a challenging and developing area of food …
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Examination of stress-induced transformations within multicomponent pharmaceutical crystals
… on improving the properties of the developed materials. Research in this area has a significant impact on large-scale manufacturing as industrial processes may give rise, at various stages, to stress-induced transformations and product modification. This thesis investigates the solid-state …
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In-situ Study of Single Pharmaceutical Granule Drying using Synchrotron X-ray Imaging
… bed drying is a key unit operation in the pharmaceutical tableting industry. To ensure homogeneity and product quality for a wide range of formulations in the final tableted product, the monitoring of changes to an individual granules structure, and therein its composition and the …