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Showing 1 to 2 of 2 for “"Pharmaceutical hot melt extrusion (HME)"”.
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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Dispersion and dissolution kinetics of API particles in pharmaceutical hot melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization …