Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Pharmaceutical formulations"”.
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Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
Pharmaceutical formulation plays an important role in transforming a drug substance into the final drug product taken by a patient. It involves processes that combine an active pharmaceutical ingredient (API) and a mixture of inactive excipients into a final drug product with desired therapeutic …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… an overview of the salient properties of pharmaceutical excipients, chitin, metal silicates and sugar alcohols in order to give a scientific background/context to the research subject matter reported in subsequent chapter of the thesis. When chitin is used in pharmaceutical formulations …
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Materials properties of pharmaceutical formulations for thin-film-tablet continuous manufacturing
… based thin-films. It is estimated that the pharmaceutical industry loses as much as a 25% on revenues based on the currently employed batch manufacturing method. Here we studied a continuous way of manufacturing tablets based on API/based polymer formulations that are cast and subsequently …
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Enhancing pharmaceutical formulations to improve efficacy and delivery of drug molecules
… however, has been placed on alternative formulations of inhibitors. We investigated the design of multivalent antivirals, wherein small molecule ligands of viral proteins are conjugated via a linker to a linear polymeric backbone. Unexpectedly, we found that a poly-L-glutamine bearing …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
This study seeks to develop smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems …
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Thermosensitive Injectable Pluronic Hydrogels for Controlled Drug Release: Characterisation of thermal, rheological and structural properties of injectable pharmaceutical formulations
This study seeks to develop smart hydrogel formulations for injectable controlled drug delivery from Pluronics to enhance patients compliance, decrease side effects, reduce dose and frequency. A biocompatible copolymer, Pluronic F127 was probed as the main ingredient for the injectable systems …
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The Development of Analytical Procedures for Analysis of Trace Metals in Pharmaceutical Formulations and the Speciation of Arsenic in Antacids
… the literature. New regulations regarding EI in pharmaceutical products were recently implemented on the 1st January 2018. The new regulations are USP <232>/<233> and the International Council for Harmonisation equivalent guidelines (ICH Q3D). The new regulations include the use of …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… composed of a polymer excipient and an Active Pharmaceutical Ingredient (API). Indomethacin (INM) is used as model API; Eudragit EPO (EPO) is used as polymer excipient; AcDiSol and Crospovidone (Cros) are used as two kinds of disintegrant. The main objectives are to gain an understanding of the …
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ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΜΟΡΙΑΚΗΣ ΕΚΠΟΜΠΗΣ ΑΠΟ ΚΟΙΛΟΤΗΤΑ
… HAVE BEEN DETERMINED SUCCESSFULLY IN PHARMACEUTICAL FORMULATIONS. THE SPECTRAL INTERFERENCE OF SULPHITE TO SULPHIDE HAS BEEN STUDIED AND A METHOD IS PROPOSED FOR THE DETERMINATION OF BOTH ANIONS IN ADMIXTURE.
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Synthesis and characterisation of hollow monodisperse silica-titania nanostructures for potential use in targeted delivery of drugs/vaccines/genes
… years, there has been a continuous growth in pharmaceutical formulations based on nanoparticle technology. Although a large number of nanocarriers have been studied, most of them are limited by their ability to carry sufficiently viable therapeutic loads, toxicity, and target specific delivery …
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Microneedle gastric retention for drug delivery
… Coupled with work in the creation of new pharmaceutical formulations, these needles can be loaded with any drug to ensure uptake into the blood stream over the course of several days.
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Formulation and preparation of niosomes containing bioactive compounds
… surfactants (niosomes) of interest in food, pharmaceutical and cosmetic industries, containing trans-resveratrol (RSV), a bioactive compound with antioxidant capacity and beneficial effects for human health. First, the suitability of niosomes to encapsulate RSV was studied using Span 80 and …
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The role of moisture profiling towards understanding pharmaceutical solid state functionality. Validation and the application of a moisture profiling analytical tool for investigation into the characterisation of and prediction of the effects of compaction and storage on different lactose physical forms
The majority of therapeutic pharmaceutical formulations are presented in the solid form. Moisture is able to play an important role in the functional performance of pharmaceutical solids. Moisture profiling is able to provide novel information with regards to the behaviour of moisture within …
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Dynamic nuclear polarization of amorphous and crystalline small molecules
… become an important technique in the studies of pharmaceutical formulations consisting of active pharmaceutical ingredients (API) and excipients. Dynamic nuclear polarization (DNP), which improves NMR sensitivity by 2-3 orders of magnitude, can potentially reduce the necessary experimental time …
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The use of ion pairs to increase the percutaneous delivery of diclofenac
Like many topically applied formulations, diclofenac (DF) preparations face delivery challenges due to the highly effective skin barrier. This research explored a novel amino acid-based ion pairing strategy to enhance percutaneous DF delivery through rational counterion selection and solvent …
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Analytical and metabolic studies of the trypanocidal diamidines
… safeguard the quality and efficacy of generic formulations of diminazene. A selective, accurate, precise and simple reverse-phase isocratic HPLC method for the simultaneous assay of diminazene aceturate and antipyrine (excipient) in pharmaceutical formulations has been developed and validated. …
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Spore-forming bacteria as pharmaceutical factories
… shows that it might be feasible to use spores as pharmaceutical formulations. A number of challenges remain: from fabrication, through limits of current good manufacturing practice, to engineering biology to protect the environment and commercial interests. Bacterial spores have for the past …
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Synthesis of corn-derived carbohydrate derivatives as effective multifunctional sunscreen
… properties as UV stabilizers in cosmetic and pharmaceutical formulations. The work described in this thesis also covers the synthesis of isosorbide-derived antioxidants and an isosorbide-derived single compound which functions as both UVB sunscreen and plasticizer. This compound can also …
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Development and Validation of a Novel Diffusion Chamber for In Vitro Permeability Testing of Topically Delivered Spray Formulations
In vitro testing of pharmaceutical formulations is an integral part of development of new drugs and formulations. The use of in vitro tests, which have a better in vitro-in vivo correlation, allows for a more efficient transition from in vitro testing to animal studies. Current testing protocol …
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