Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Pharmaceutical drugs"”.
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The application of physicochemical methods for the analysis of small and complex pharmaceutical drugs
… methods for the analysis of small and complex pharmaceutical drugs was investigated. The methods were applied to small chiral molecules and further extended to analysis of complex glycoconjugate vaccines.
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Effects of Experimental Scale on the Adsorption of Two Pharmaceutical Drugs Detected in Municipal Wastewater Effluent
<p>Pharmaceutical drugs are being produced and consumed in increasing quantities every year and are poorly treated by conventional wastewater treatment processes, leading to increasing detection of such compounds in surface water, groundwater, and municipal drinking water. Soil aquifer treatment …
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Practical Applications of Infrared, Raman and Nuclear Magnetic Resonance Spectroscopic Techniques for Qualitative, Quantitative and Structural Analysis of Pharmaceutical Drugs, Cementitious Material and Organic Molecules Containing Phosphorous
… of quantitative analytical techniques in pharmaceutical research, as, both of these techniques have been successfully applied to the study of polymorphism in pharmaceutical drugs at both the qualitative and quantitative levels. The investigation of our research presented in this …
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Addressing Legal Liability Issues in Cases of Harm due to Agricultural Genetically Modified Organisms (GMOs): Does current liability law find a suitable balance between the injuring and injured party?
… biological and medical research, production of pharmaceutical drugs, experimental medicine and agriculture.
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Modulating macrophage phenotype for obesity therapy
… and bone density over time. Anti-inflammatory pharmaceutical drugs can theoretically address the chronic inflammation originating from adipose tissue, but these drugs have significant off target effects, like gastrointestinal distress and liver toxicity, which limit their potential for …
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Quantitative Determination of Acetylsalicyclic Acid and Acetaminophen by Q-NMR (Quantitative Nuclear Magnetic Resonance) Technique
<p>The pharmaceutical industry mainly uses chromatographic techniques such as High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC), to determine the quantity of the active ingredient and other material in the drugs. A large effort goes into developing methods using …
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Optimization of Fermentation Conditions for the Production of Legionaminic Acid in Recombinant Escherichia Coli
… acid has great potential in the production of pharmaceutical drugs. A novel biosynthetic pathway to produce legionaminic acid was created to overcome the limitations of organic synthesis. This is the first study involving the scale-up of legionaminic acid production by high cell density …
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Remote asymmetric induction in the organocatalytic azaDarzens synthesis of peptide aziridines: towards the assembly of new glycopeptide antibiotic analogues
… the successful approaches which have brought new pharmaceutical drugs to the market. The results and discussion section of this work focusses first on the synthesis of a triaryl biether structure, which is a common feature of the glycopeptide antibiotic family and represents the beginning of a …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
… to cancer and neurodegenerative diseases. Pharmaceutical drugs are being developed to target TRM, however studies are needed to understand the role of each macrophage population in inflammatory conditions. Here we examine omental resident macrophages (ORM) in early tumor seeding conditions. …
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Physicochemical study of inclusion of drug molecules in cyclodextrins
… use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the pharmaceutical and chemical fields. For this study the inclusion of nine pharmaceutical drugs with CDs was investigated in the solid …
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Functional ionic liquids in crystal engineering and drug delivery
… liquids have a wide range of applications in pharmaceutical field due to their unique physicochemical propertie ssuch as chemical, thermal stability, low melting point, nonvolatility, nonflamability, low toxicity and recyclability which offer unique and interesting potential for pharmaceuitcal …
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Analysis of enzymatic L/D-peptide isomerization in animals
… processes and improves the effectiveness of pharmaceutical drugs. While protein synthesis in animals is stereospecific for all L-form amino acids, a unique and bioactive group of D-amino acid-containing peptides (DAACPs) have been found to exist in a broad array of animals. DAACPs result from …
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Application of machine learning methods for design of crystallisation processes
… the implementation of machine learning to aid in pharmaceutical process development. Machine learning (ML) algorithms can be applied to increase the speed with which high-value drug products are developed for the market while reducing the utilisation of material, minimising wastage and assuring …
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Bodies of Evidence: An Anthropology of the Health Claim
… an uneasy relationship between the ecology of pharmaceutical drugs, and an ecology-yet-to-be-made for food therapeutics. Such an ecology rests upon a pattern of collaboration -or agencement- between materials and humans pertaining to different realms of production, regulation and science. As …
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QUANTIFICATION OF ASPARTAME IN LOZENGES AND TABLETOP SWEETENERS VIA MULTIPLE PARAMETER MANIPULATION BY USING DISSOLUTION STUDIES WITH UV-VIS, ULTRA-HPLC, AND MATHEMATICAL DRUG MODELING
… price. Additionally, aspartame is found in many pharmaceutical drugs to mask the bitter taste of the active pharmaceutical ingredient (API). For instance, lozenges are solid intraoral dosage forms intended to slowly release the API into the oral cavity. Aspartame is used in lozenges to impart a …
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Investigating the role of routine drug analyses in survivors of sexual offences admitted to the clinical forensic unit at Victoria Hospital
… mass spectrometry (LC-MS/MS) method for common drugs of abuse in cases of suspected drug facilitated sexual offences. Methods: Blood and urine samples from 17 consenting adult survivors, who reported to the Clinical Forensic Unit at Victoria Hospital (August 2022 – December 2022) in Cape Town, …
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Stereoselective Heterocycle Synthesis via Alkene Difunctionalization: Bulky Phosphine Ligands Enable Pd-Catalyzed Arylhalogenation, Arylcyanation and Diarylation
… scaffolds in naturally occurring compounds and pharmaceutical drugs, an important longterm goal in organic chemistry has been developing new heterocycle syntheses. Research in the Lautens group has led to many advances in this field, specifically using Rh and Pd as catalysts. Our group recently …
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Early Diagnosis of Alzheimer's Disease and Studying Binding to Opioid Receptors using Whispering Gallery Mode Microtoroid Biosensors
… and mood, and are a potential target for novel pharmaceutical drugs as an alternative for pain management with lower potential for addiction than other opioid receptors. Lastly, microtoroids were used as a platform for early diagnosis of Alzheimer’s disease (AD), a form of dementia characterized …
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Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… developing gametes (F2). Recently, the effect of pharmaceutical drugs on the epigenome has come to light with more novel drugs being designed to target the epigenome. The epigenome is vital for successful development, therefore, it is important to understand the risk of exposure to current and …
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Science and technology driving change in drug R&D : some lessons for the Japanese pharmaceutical industry
… platform in the research and development of pharmaceutical drugs is changing dramatically -- from the traditional trial-and-error method to modem sophisticated methods that use Combinatorial Chemistry (CC), High Throughput Screening (HTS), and Gene Technology. Since the beginning of the …
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