Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Pharmaceutical crystallization"”.
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Computer-aided rational solvent selection for pharmaceutical crystallization
Solvents play an important role in crystallization, a commonly used separation and purification technique in the pharmaceutical, chemical and food industries. They affect crystal properties such as particle size distribution, morphology, polymorphism etc. and therefore have consequences for the …
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Pharmaceutical crystallization design using micromixers, multiphase flow, and controlled dynamic operations
Crystallization is a key unit operation in the pharmaceutical industry. Control of crystallization processes can be challenging when undesirable phenomena such as particle attrition and breakage occur. This thesis describes the controlled crystallization of pharmaceuticals and amino acids for more …
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DEVELOPMENT OF NOVEL DESIGN AND CONTROL APPROACHES FOR INTEGRATED CRYSTALLIZATION OPERATION AND SYSTEMS
Crystallization is an important separation and purification technique for a wide variety of solid products in pharmaceutical, food and fine chemical industries. The production of more than 90% of the active pharmaceutical ingredients (APIs) involves crystallization. Therefore, it is crucial to …
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Microfluidic platforms for solid form screening of pharmaceutical parent compounds
Solid form screening and selection of pharmaceutical parent compounds (PCs) has been identified as a critical step in the early stages of drug development. A significant fraction of candidate PCs are rejected on account of poor physicochemical properties that affect their biopharmaceutical …
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Solvent compatible microfluidic platforms for solid form screening of pharmaceutical parent compounds
A significant fraction of candidate pharmaceutical parent compounds (PCs) are rejected on account of poor physicochemical properties that affect their biopharmaceutical attributes such as bioavailability, toxicity, and stability. Hence, a major factor contributing to the high costs and turnaround …