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Showing 1 to 6 of 6 for “"Pharmaceutical cocrystals"”.
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
… novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to investigate the influence of variable parameters and conditions on the process of cocrystal conversion. The potential for the active control of …
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Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
… and permeation properties of flufenamic acid cocrystals in the presence of polymers. This study was separated into four tasks: (1) Formation of pharmaceutical cocrystals: Two pharmaceutical cocrystals of poorly water soluble active pharmaceutical ingredient (API) flufenamic acid (FFA) were …
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Crystal Engineering of Flavonoids
… engineering is attracting attention in the pharmaceutical industry because the design of new crystal form of drugs can improve their stability, bioavailability and other relevant physical characteristic properties. Therefore, crystal engineering of nutraceuticals such as flavonoids by …
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Diffraction Between the Spots: Scanning Electron Diffraction of Beam-sensitive Disordered Materials
… through pair distribution function analysis, in pharmaceutical cocrystals through nanoscale twist characterisation, and in polymers through semi-crystalline variance and correlation analyses. As all information is contained within a single scan, all of this analysis is done at doses low enough to …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… the phase transformation and release profiles of cocrystals. Pharmaceutical cocrystals of Carbamazepine (CBZ) (namely 1:1 carbamazepine-nicotinamide (CBZ-NIC), 1:1 carbamazepine-saccharin (CBZ-SAC) and 1:1 carbamazepine-cinnamic acid (CBZ-CIN) cocrystals, were synthesized. A Quality by Design …
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… of sustained release formulations. Extruded pharmaceutical cocrystals were manufactured by using carbamazepine (CBZ) as a model drug with saccharine (SCH) and trans-cinnamic acid (TCA) as coformers at a 1:1 molar ratio. In-line NIR was employed to monitor the cocrystallization process along …