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Showing 1 to 20 of 83 for “"Pharmaceutical Preparations"”.
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Analytical Studies Concerning the Stability of Betamethasone Valerate and Fusidic acid Hemihydrate in Topical Pharmaceutical Preparations
… and fusidic acid hemihydrate in topical pharmaceutical formulations. In particular, the work concentrates on formulation factors affecting the intra-molecular isomerisation of betamethasone 17-valerate to 21-valerate in a developmental topical cream for treatment of atopic dermatitis and …
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Quantitative Analysis by Room-Temperature Phosphorescence
… RTP. The analytes that were determined include pharmaceuticals in body fluids and pharmaceutical preparations. A combination of standard addition and internal standard techniques along with sophisticated instrumental and mathematical techniques were developed to improve the precision and …
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The synthesis of aminophosphonic acid derivatives & related compounds
… properties, extractants, wetting agents, pharmaceutical preparations, ion exchangers, herbicides, compounds with plant growth regulatory activity; inhibitors of aminopeptidases; as structural units in peptide analogues, functioning as antibacterial agents, which inhibit bacterial cell wall …
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Qualidade microbiológica de preparações líquidas comercializadas em farmácias magistrais de João Pessoa - PB.
The pharmaceutical market has always exerted a major influence in the world , as well as in Brazil, which has been a center of cultural development of great significance. The manipulation pharmacy has been gaining more space in the pharmaceuticals Market, since its decline after World War II. In …
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New liquid chromatographic methods for the analysis of cationic tensides
… that are used to prevent adulteration of pharmaceutical preparations and personal care products, as well as being the conditioning agents in domestic fabric softeners. The widespread use of these materials requires quantitative methods for characterising them in raw materials and fully …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
… a leading technology that can be applied to many pharmaceutical preparations as solid dispersions. Part of this research project focus on injecting pressurized carbon dioxide (P-CO2) gas during the HME process. These combined techniques have an additional advantage of being adaptable and portable …
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Investigation of the factors contributing to the physical stability of biological therapeutics
… method of measuring water content in pharmaceutical preparations using time-domain NMR was developed in collaboration with AstraZeneca. It was then used to investigate whether water content can alter the physical stability of a therapeutic peptide, however, results were somewhat …
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… is commercially available in several different pharmaceutical preparations as a free radical scavenger.</p> <p>Since few scientific studies have documented the pharmacologic effects of pycnogenol, our objective was to characterize the biological activity of pycnogenol. One study looked at the …
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Vaistininkų ir pacientų naudojami farmacinės informacijos šaltiniai /
… Vilnius Topic of the master thesis: The Research Pharmaceutical Information Sources used by Pharmacists and Patients. Goal of the work: to research and assess the sources of pharmaceutical information used by pharmacists and patients. Tasks: 1. To review the availability of pharmaceutical …
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Physicochemical characterisation of cyclodextrin-drug complexes
… are finding increasing application in the pharmaceutical industry as carrier molecules for many drugs, as complexation can result in improved physical characteristics such as increased aqueous solubility and dissolution rates. The aim of this work was to prepare solid cyclodextrin complexes …
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Macromolecule Loading on PLGA Particles through Surface Adsorption
<p>The advent of biotherapeutics have impacted the ways in which diseases are treated. In many instances development of recombinant proteins and oligonucleotides into therapeutics are slowed by poor stability of the candidate drugs. Progress has been made in using polymeric particles as carriers of …
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Novel Lipid Polymer Design for Nucleic Acids Delivery
<p>RNA interference (RNAi) is a powerful tool that can selectively downregulate the expression of any protein without the need for expensive and time-consuming drug development processes. Despite the initial excitement and extensive efforts, the potential impact of RNAi in clinical settings has …
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Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma
… project, ForSight Laboratories has developed a pharmaceutical drug delivering implant with the capability of sustaining long-term release of a prostaglandin as a new way to treat the condition. This project reports the product development of a polymer drug matrix with a controlled release in …
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
<p>Antibody-drug conjugates (ADCs) are a fast-growing class of molecularly targeted therapies with 13 currently approved and over a 100 in clinical trials. ADCs consist of a monoclonal antibody (mAb) conjugated to a potent cytotoxic payload to selectively target tumor antigens highly expressed on …
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Preparation of Supramolecular Amphiphilic Cyclodextrin Bilayer Vesicles for Pharmaceutical Applications
<p>Recent pharmaceutical developments have investigated using supramolecular nanoparticles in order to increase the bioavailability and solubility of drugs delivered in various methods. Modification of the carbohydrate cyclodextrin increases the ability to encapsulate hydrophobic pharmaceutical …
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EFFECT OF HISTIDINE TAG ON THE ENZYMATIC ACTIVITY OF PSEUDOLYSIN AND ITS INTERACTION WITH THE STREPTOMYCES METALLOPROTEASE INHIBITOR (SMPI) PROTEIN
<p>Pseudolysin (PLN) protein is a major virulent factor in <em>Pseudomonas</em> <em>aeruginosa </em>infection. PLN belongs to the family of zinc-dependent metalloproteases. It is naturally inhibited by a smaller protein called streptomyces metalloprotease inhibitor (SMPI), secreted by …
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Antibiotic Drug Discovery with an Eye Towards Overcoming Drug Resistance
<p>As a species, humans have become ever reliant on the use of antibiotics to facilitate our everyday lives. The widespread emergence of resistance to currently used antibiotics is commonly attributed to an over use in our society. Such resistance, coupled with a lack of innovation and production …
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Diastereoselective acylation of trans-2-substituted-cyclohexanols and glycosidase inhibition studies
<p>Part I. The reaction between chiral acyl chlorides and trans -2-substituted-cyclohexanols proceeds diastereoselectively, i.e. produces mixtures of unequal amounts of diastereomers. We found for the first time that addition of pyridine or diisopropylethylamine accelerates the acylation, and …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
<p>Candida albicans is a pathogenic fungi found in the mucosa, gastrointestinal, and urogenital tracts of humans. Oropharyngeal candidiasis (OPC), an opportunistic mucosal infection caused by C. albicans, occurs most frequently in patients infected with human immunodeficiency virus (HIV). OPC is …
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