Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Phagocytes"”.
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The pulmonary phagocytes and phagocytosis.
Abstract not available.
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
Mononuclear phagocytes (MNP), consisting of monocytes, macrophages and dendritic cells (DC), are major cell types of the innate immune system and their activation is required for an effective immune response, including the anti-cancer response. Tumour-associated macrophages (TAM) are a universal …
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
Resident mononuclear phagocytes (MNPs) play key roles in tissue homeostasis, defence against infection and repair. Although MNPs have been studied for more than 130 years, there have been significant advances in our understanding of their role, origin, maintenance and interactions in recent years, …
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Conserved Role of EGFR Signaling in Apoptotic Cell Recognition and Processing Across Different Phagocytes
… by which apoptotic cells recruit and activate phagocytes remain poorly understood. Here, we show that EGFR signaling is both necessary and sufficient for efficient efferocytosis in two diverse phagocytes: the gonadal sheath cells of C. elegans and the zebrafish microglia. In C. elegans, loss of …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
… infiltration are poorly understood. Mononuclear phagocytes (MPs) are abnormal in PsA, involved in neovascularisation, and the production/development of key cytokines and adaptive effectors. I aimed to identify the key interactions that drive MPs migration to joint tissue in active treatment-naïve …
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Optimization and Validation of the Derivation and Use of HoxB8 Transgenic Murine Phagocytes in In Vitro Studies
… reported in this body of work suggest that phagocytes derived from HoxB8 conditionally immortalized progenitor cells are more similar to primary phagocytes as compared to other immortalized phagocyte-like cell lines.
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… IFN-γ receptor (IFN-γR) signaling in mononuclear phagocytes induces tumor necrosis factor (TNF)-α hyperproduction and lethal inflammatory lung damage, with no detectable benefit to viral or bacterial clearance. In contrast, we show that interleukin (IL)-10 is crucial to counteract the lethal …
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Investigating milk cell population changes in response to heat stress and characterizing functionality of epithelial cells in milk of lactating dairy cows
… potential role of mammary epithelial cells as phagocytes in consuming apoptotic mammary epithelial cells during lactation. Mammary epithelial cells act as non-professional phagocytes during the dry period to aid in maintaining tissue homeostasis. The role of mammary epithelial cells as …
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Age-Dependent Determinants of Blood-Derived Monocytes Influence Neuroinflammatory Milieu at the TBI Injury Site
… and morphology of BDMs and resident mononuclear phagocytes during the acute phase of injury. We also looked at the population and polarization of resident mononuclear phagocytes during the chronic phase of TBI. We found an overall reduction in tissue damage in juvenile injected mice, and the …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
Nonopsonic invasion of mononuclear phagocytes by Mycobacterium tuberculosis (M. tb.) is likely important in the establishment of a primary infection in the lung. M. tb. binds to a variety of phagocyte receptors, of which the mannose receptor and the complement receptor type 3 (CR3) may support …
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Jak-stat pathway in the control of mycobacterial infections
… or in which the JAk/STAT pathway is inhibited in phagocytes, show improved survival, decreased mycobacterial numbers, and delayed immune cell death. Strikingly, I find that JAK/STAT signalling acts in concert with other inflammatory signals to regulate expression of Atg2 in Drosophila phagocytes. …
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Novel detection and evasion mechanisms pertinent to immunity against Salmonella Typhimurium
… protection, thus becoming internalised by phagocytes less efficiently than control bacteria. Phagocytosis protection was acquired rapidly after S.Typhimurium infection and was not observed with dead bacteria. Phagocytosis protection is only partially reversed by opsonisation in human serum. …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… infection triggers microglia and monocytes (i.e. phagocytes) to target, ensheath, and remove perisomatic inhibitory synapses on neuronal somata indiscriminately, or whether specificity exists in this type of circuit remodeling, remained unclear. Through a comprehensive assessment of phagocyte …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… differences between young and old phagocytes involved in myelin debris clearance, thereby identifying therapeutically modifiable pathways associated with efficient myelin debris phagocytosis. In this study, we show that expression of genes involved in the retinoid X receptor (RXR) …
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The Population and Activity of Airway Macrophages in Patients Requiring Continuous Mechanical Ventilation
… relationship with other cell types and role as phagocytes is not well defined. In this study a technique utilizing a high speed blender was developed to allow separation of the adherent cell population from highly mucoid specimens. Many adherent cells failed to demonstrate phagocytosis. Those …
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Sortases: Keystones to Virulence and Targets for Anti-Infective Therapy
… of reactive oxygen species by professional phagocytes could lead to inhibition of SrtA via oxidation of a conserved nucleophilic cysteine residue in the active site. Through determination of inhibition kinetics, identification of oxidative modifications, reduction potential measurements, and …
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Effects of Maternal Iron Deficiency During Reproduction on Phagocytosis, Antibody Formation and Cell Growth in the Suckling Rat (Immune Response)
… ppm iron pups, despite a significant increase in phagocytes/ul blood. Plasma lysozyme and peroxidase activities were increased in 6 ppm iron pups. Hyperlipidemia and release of immature phagocytes from bone marrow (left shift) were possible mechanisms for the impaired phagocytosis. In Experiment …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… deiminated chromatin may be internalized by host phagocytes during inflammatory conditions, as arise during bacterial infections or chronic autoinflammatory disorders. The uptake and processing of deiminated chromatin together with bacterial adjuvants by phagocytes may induce the presentation of …
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Dosage Window of Selenium on Human Natural Killer Cytotoxicity and Neutrophilmediated Chemiluminescence
… (GSH-Px) was also determined in NK cells and phagocytes following selenite supplementation. Dose-dependent augmentation of phagocytic activity by selenite supplementation was accompanied by a corresponding increase in phagocyte GSH-Px activity. The effect of Se treatment on non-adherent cell …
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Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
… that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the host cell nucleus and binds regulatory regions of host …
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