Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Phage therapy"”.
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Phage therapy applications: Efficacy and impact on the animal intestinal microbiome
Phage therapy is a promising antibacterial intervention that has received renewed interest in recent years. In this study, the antibacterial efficacy of phage treatments was tested in different food matrices, under different conditions, as well as in both phage cocktail and single phage forms. …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
… notably hospitalised patients on antibiotic therapy and those with other types of gastrointestinal conditions. This opportunistic infection is caused by a Grampositive, spore-forming bacillus, with conditions including diarrhoea, pseudomembranous colitis, and toxic megacolon. Antibiotic …
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The relevance of bacteriophage therapy in the era of antibiotic resistant bacteria
… set out to examine the potential of bacteriophage (phage) therapy as an alternative or complementary means of treating bacterial infection. Phage therapy is used as a frontline antibacterial therapy in the former Soviet bloc countries but remains an unexplored technology in Western science. …
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The Phight for Phage: Understanding Bacteriophage Therapy in Aquaculture and Human Health
… biological particle on our planet: bacteriophage. Often called phage, these microscopic viruses infect bacteria, and their high specificity and incredible abundance may make them viable treatment options. Scientists have known about phage for over a century, but renewed interest over the …
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Exploiting Bacteriophages to Tackle Clostridium difficile Infection
… of studies investigating the potential use of phage. The project involved extensive screening including faecal samples and environmental sources in an attempt to identify novel phages of C. difficile and documents efforts to improve the therapeutic capacity of a selected phage, ФCD27, by …
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Investigation of flagellotropic phage interactions with their motile host bacteria
Bacteriophages cohabit with their bacterial hosts and shape microbial communities. To initiate infection, phages use bacterial components as receptors to recognize and attach to hosts. Flagellotropic phages utilize bacterial flagella as receptors. Studies focused on uncovering mechanistic details …
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Genetic mechanisms contributing to antimicrobial resistance: gene repression in Mycobacterium, gene transfer in Salmonella, and phage sensitivity in Escherichia
… competence in Salmonella Typhimurium, and phage therapy of Enterohemorrhagic Escherichia coli serogroup O157:H7. A recent study showed specific mutations in the uncharacterized locus mmpT5 increased resistance to anti-TB drug bedaquiline in M. intracellulare lung infections. Based on …
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Characterisation of bacteriophage dynamics associated with foodborne pathogens
Bacteriophages (phages) are viruses that infect bacteria and are found in high abundance in the gut. As antimicrobial resistance rises and interest in microbiome-targeted therapies grows, phages have emerged as potential tools for precisely modulating microbial communities and treating infections. …
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Bacteriophages and their hosts: an investigation into veterinary Pseudomonas aeruginosa strains and the phages isolated against them
… bacteria has meant that the interest in phage therapy as an alternative to antibiotics has likewise been growing. In particular, *Pseudomonas aeruginosa* is an opportunistic pathogen for which novel treatments are urgently needed, as demonstrated by the World Health Organisation (WHO) …
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Determining the mechanism of protein transit through the peptidoglycan layer in Gram-positive bacteria and identifying phage-docking sites on Clostridium perfringens
… the cells. For both routes of infection, bacteriophages could supplement or entirely replace antibiotics. This could help greatly reduce the amount of collateral damage to the microbiome in gastrointestinal infection due to high phage specificity. A more speculatory approach is administering …
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Studies on vibrio cholerae
… In cholera. Alternatively, it may be that phage therapy still is worthy of consideration but this is doubtful. The control of cholera depends on several factors. (i) Improvement of {sanitation, provision of safe water, satisfactory disposal of excreta and health education of the public to …
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Advancing single cell microbiology and bacteriophage-bacteria interactions using microfluidics and image-based deep learning
… of individual bacteria to antibiotics or bacteriophages. This thesis addresses these challenges by developing integrated, label-free, droplet-based microfluidic platforms coupled with advanced deep learning algorithms for studying bacteriophage-host interactions towards high-throughput single-cell …
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Two strategies to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci: comparative transcriptomic of two DAP-R/DAP-S MRSA isogenic couples and CRISPR system characterization of pathogenic S. epidermidis
… characterization of the CRISPR-Cas system and phage infection sensitivity tests of ten Italian pathogenic clinical MDR S. epidermidis strains were performed to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci. Results of transcriptomic analysis showed the …
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Functionalization of phage endolysins to treat infections of spore-forming Clostridia bacteria in the era of antibiotic resistance
… pathogen. Research on *Clostridia* spores and phage therapy has been limited to a selection of species, partially because of their anaerobic nature. While recent work has endeavoured to bridge this gap, there is still a pressing need to understand the resistance mechanisms of *Clostridia* …
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Towards bioengineered ecosystems: Three studies in invasion biology
… Chapter 4 introduces a mathematical model for a phage-bacterium ecosystem. From an invasion biology standpoint, either the phage or the bacterium can be considered as an invader, depending on the ecosystem they inhabit and also on one's point of view. A model was developed to describe an …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… of PC3 cells with Cl-am prior to chemotherapy, exhibited increased activity of Dox and increased drug retention was shown by fluorescent microscopy, HPLC, FCM and fluorescence spectrophotometry. Overall the findings demonstrated the implication of EV inhibitors in improving chemotherapy …
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Evolution and engineering of protein-protein interactions
… inhibit toxin-antitoxin-mediated bacterial anti-phage defense activity, suggesting their potential use in clinical phage therapy applications. Taken together, these results shed light on the role of protein-protein interactions and their specificity in shaping evolution and suggest the utility of …
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CRISPR immune diversity in simulated and natural microbial populations
… prototyping, revealed a panmictic P. aeruginosa phage population and holds promise as a tool for tracking mobile elements and personalizing phage therapy treatments.
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Biophysics of Helices: Devices, Bacteria and Viruses
… then turns to the sub-bacterial scale of bacteriophage viruses, ‘phages’ for short, that infect bacteria by ejecting their genetic material and replicating inside their host. The valuable insight that phages can offer in our fight against pathogenic bacteria and the possibility of phage therapy as …
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The interplay between pathogenic bacteria and bacteriophage Chi: New directions in motility and phage-host interactions in Enterobacterales
… as flagellotropic or flagellum-dependent bacteriophages. Much like other phages, flagellotropic phages are of interest for clinical applications as antibacterial agents, particularly against multidrug resistant (MDR) bacteria. Bacteriophage χ is a flagellotropic phage that infects multiple species …
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