Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Phage resistance"”.
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Phage therapy applications: Efficacy and impact on the animal intestinal microbiome
Phage therapy is a promising antibacterial intervention that has received renewed interest in recent years. In this study, the antibacterial efficacy of phage treatments was tested in different food matrices, under different conditions, as well as in both phage cocktail and single phage forms. …
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ToxIN-mediated resistance to and cell-free production of Salmonella bacteriophages
… these limitations is the application of bacteriophage cocktails, consisting of numerous bacterial viruses which kill the target pathogen. However, the use of phages also comes with two significant drawbacks: phage resistance and manufacturing hurdles. Resistance to phages may reduce the efficacy …
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The evolutionary ecology of methylation-dependent bacterial defense systems
… Given the role of MGEs in spreading drug resistance alleles, the current focus on developing bacteriophages as alternative antimicrobials, and the ability for host defenses to interfere with both, it is essential to more fully understand these eco-evolutionary dynamics. As these dynamics …
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Toxin-antitoxin systems in bacteria : targets, mechanisms, and specificity
… processes, including plasmid stability, phage resistance, persistence, and virulence. Yet, there are a number of unanswered questions about these genetic modules. What are the cellular targets of toxins? How do antitoxins antagonize their cognate toxins? Do toxins and antitoxins interact …
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Biochemical Studies of Peptidoglycan Hydrolases from Commensal and Pathogenic Bacteria
… therapy. Strains of E. faecium Com12 displaying resistance to a particular phage encoded sagA mutations localized at the NlpC/p60 domain. Phage resistance upon sagA mutation coincided with an antibiotic fitness tradeoff that was exploited to discover the synergistic effect of phage-antibiotic …